Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
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AbstractPsilocybin is a serotonergic psychedelic with untapped therapeutic potential. Here we chronically imaged apical dendritic spines of layer 5 pyramidal neurons in mouse medial frontal cortex. We found that a single dose of psilocybin led to ∼10% increases in spine density and spine head width. Synaptic remodeling occurred quickly within 24 hours and was persistent 1 month later. The results demonstrate structural plasticity that may underpin psilocybin’s long-lasting beneficial actions.
2016 ◽
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2011 ◽
Vol 119
(5)
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pp. 1064-1073
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