Tractography-based targeting of ventral intermediate nucleus: A comparison between conventional stereotactic targeting and diffusion tensor imaging-based targeting

AbstractBackgroundThe ventral intermediate (VIM) nucleus of the thalamus is the main target for lesioning using magnetic resonance imaging (MRI) guided focused ultrasound (MRgFUS) or deep brain stimulation (DBS). Targeting of VIM still depends on standard stereotactic coordinates, which do not account for inter-individual variability. Several approaches have been proposed including visualization of dentato-rubro-thalamic tract (DRTT) using diffusion tensor imaging tractography.ObjectiveTo compare probabilistic tracking of DRTT with deterministic tracking of DRTT and stereotactic coordinates to identify the most appropriate approach to target VIM.MethodsIn this retrospective study, we assessed the VIM targeted using stereotactic coordinates, deterministic and probabilistic tracking of DRTT in 19 patients with essential tremor who underwent DBS with VIM targeted using microelectrode recordings. We subsequently determined the positions of VIM derived from these three approaches and compared with that of DBS lead position using paired sample t-tests.ResultsThe probabilistic tracking of DRTT was significantly anterior to the lead (1.45 ± 1.61 mm (P< 0.0001)), but not in the medial/lateral position (−0.29±2.42 mm (P=0.50)). Deterministic tracking of DRTT was significantly lateral (2.16 ± 1.94 mm (P< 0.0001)) and anterior to the lead (1.66 ± 2.1 mm (P< 0.0001)). The stereotactic coordinates were significantly lateral (2.41 ± 1.41 mm (P< 0.0001)) and anterior (1.23 ± 0.89 mm (P< 0.0001)) to the lead.ConclusionProbabilistic tracking of DRTT was found to be superior in targeting VIM compared to deterministic tracking and stereotactic coordinates.

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Progressive Supranuclear Palsy and Diffusion Tensor Imaging

European Neurological Review ◽

10.17925/enr.2009.04.02.108 ◽

2009 ◽

Vol 4 (2) ◽

pp. 108 ◽

Cited By ~ 1

Author(s):

Shoichi Ito ◽

Keyword(s):

Diffusion Tensor Imaging ◽

Progressive Supranuclear Palsy ◽

Diffusion Tensor ◽

Anterior Part ◽

Internal Capsule ◽

Neural Systems ◽

Cerebellar Peduncles ◽

Magnetic Resonance Imaging Mri ◽

And Diffusion ◽

Diffusion Properties

Progressive supranuclear palsy (PSP) is a neurodegenerative disease affecting multiple neural systems, particularly the extrapyramidal system. Early differentiation of PSP from other diseases mainly featuring parkinsonism, such as Parkinson's disease and multiple system atrophy, is necessary because the therapeutic strategy and outcome are substantially different. Diffusion tensor imaging is a recently developed magnetic resonance imaging (MRI) sequence that is able to non-invasively evaluate neural tracts. Two approaches may be used to measure diffusion properties. One approach is to measure diffusion properties by setting the regions of interest on circular/square regions or along the tractography. The other approach is to perform voxel-by-voxel analysis of the diffusion properties. There are several reports evaluating diffusion tensor abnormalities in PSP, and regions with diffusion tensor abnormlities are distributed through frontal projection fibres, the anterior part of the corpus callosum, superior longitudinal fasciculus, arcuate fasciculus, posterior thalamic radiations, internal capsule and superior cerebellar peduncles. Here, diffusion tensor studies in PSP are reviewed and clinical applications, limitations and future perspectives of diffusion tensor analysis in PSP are discussed.

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Pitfalls in Diffusion-Weighted and Diffusion Tensor Imaging of the Pediatric Brain

Neuropediatrics ◽

10.1055/s-0037-1603979 ◽

2017 ◽

Vol 48 (05) ◽

pp. 340-349 ◽

Cited By ~ 4

Author(s):

Nivedita Agarwal ◽

Aylin Tekes ◽

Andrea Poretti ◽

Avner Meoded ◽

Thierry Huisman

Keyword(s):

Diffusion Tensor Imaging ◽

Diffusion Tensor ◽

Wide Spectrum ◽

Qualitative Evaluation ◽

Basic Knowledge ◽

Brain Diseases ◽

Water Molecules ◽

Diffusion Weighted ◽

Magnetic Resonance Imaging Mri ◽

And Diffusion

AbstractDiffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) are advanced magnetic resonance imaging (MRI) techniques that are based on differences in the diffusion rate of water molecules in brain tissue. DWI and DTI are widely used in pediatric neuroradiology to evaluate a wide spectrum of brain diseases. The interpretation of DWI and DTI images requires a basic knowledge of the underlying physics to detect potential pitfalls and avoid misinterpretation. Several DWI pitfalls are related to the dependency of DWI images not only on the diffusivity of water molecules, but also on various additional MRI phenomena such as the T1- and T2- relaxation characteristics and MRI-related artifacts. In addition, knowledge about the age of the child and interval between the onset of injury and acquisition of DWI/DTI images is important. Finally, qualitative evaluation (“eye-balling”) maybe misleading, and the application of quantitative measurements of DTI scalars may avoid misdiagnosis.

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Medial forebrain bundle stimulation elicits psychotropic side effects in Subthalamic Nucleus Deep Brain Stimulation for PD – new insights through Diffusion Tensor Imaging

Aktuelle Neurologie ◽

10.1055/s-0029-1238842 ◽

2009 ◽

Vol 36 (S 02) ◽

Cited By ~ 1

Author(s):

VA Coenen ◽

T Hurwitz ◽

J Panksepp ◽

B Mädler ◽

CR Honey

Keyword(s):

Diffusion Tensor Imaging ◽

Deep Brain Stimulation ◽

Side Effects ◽

Subthalamic Nucleus ◽

Brain Stimulation ◽

Medial Forebrain Bundle ◽

Diffusion Tensor ◽

Through Diffusion ◽

Deep Brain

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Faculty Opinions recommendation of Magnetic resonance neurography and diffusion tensor imaging of the peripheral nerves in patients with Charcot-Marie-Tooth Type 1A.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727611887.793566457 ◽

2019 ◽

Author(s):

Jun Li

Keyword(s):

Diffusion Tensor Imaging ◽

Magnetic Resonance ◽

Peripheral Nerves ◽

Diffusion Tensor ◽

Magnetic Resonance Neurography ◽

Charcot Marie Tooth ◽

Tooth Type ◽

And Diffusion

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Meyer’s Loop Anatomy Demonstrated Using Diffusion Tensor MR Imaging and Fiber Tractography at 3T

Acta Medica Marisiensis ◽

10.2478/amma-2014-0045 ◽

2014 ◽

Vol 60 (5) ◽

pp. 215-222 ◽

Cited By ~ 1

Author(s):

Cristina Goga ◽

Zeynep Firat ◽

Klara Brinzaniuc ◽

Is Florian

Keyword(s):

Diffusion Tensor Imaging ◽

Diffusion Tensor ◽

Region Of Interest ◽

Fiber Tractography ◽

Brain Images ◽

3 Dimensional ◽

Software Release ◽

Magnetic Resonance Imaging Mri ◽

Meyer’S Loop

Abstract Objective: The ultimate anatomy of the Meyer’s loop continues to elude us. Diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) may be able to demonstrate, in vivo, the anatomy of the complex network of white matter fibers surrounding the Meyer’s loop and the optic radiations. This study aims at exploring the anatomy of the Meyer’s loop by using DTI and fiber tractography. Methods: Ten healthy subjects underwent magnetic resonance imaging (MRI) with DTI at 3 T. Using a region-of-interest (ROI) based diffusion tensor imaging and fiber tracking software (Release 2.6, Achieva, Philips), sequential ROI were placed to reconstruct visual fibers and neighboring projection fibers involved in the formation of Meyer’s loop. The 3-dimensional (3D) reconstructed fibers were visualized by superimposition on 3-planar MRI brain images to enhance their precise anatomical localization and relationship with other anatomical structures. Results: Several projection fiber including the optic radiation, occipitopontine/parietopontine fibers and posterior thalamic peduncle participated in the formation of Meyer’s loop. Two patterns of angulation of the Meyer’s loop were found. Conclusions: DTI with DTT provides a complimentary, in vivo, method to study the details of the anatomy of the Meyer’s loop.

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Deep Brain Stimulation for Tremor: Update on Long-Term Outcomes, Target Considerations and Future Directions

Journal of Clinical Medicine ◽

10.3390/jcm10163468 ◽

2021 ◽

Vol 10 (16) ◽

pp. 3468

Author(s):

Naomi I. Kremer ◽

Rik W. J. Pauwels ◽

Nicolò G. Pozzi ◽

Florian Lange ◽

Jonas Roothans ◽

...

Keyword(s):

Deep Brain Stimulation ◽

Brain Stimulation ◽

Focused Ultrasound ◽

Neurosurgical Procedures ◽

Drug Resistant ◽

Long Term Outcomes ◽

Future Directions ◽

Ventral Intermediate Nucleus ◽

Deep Brain

Deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus is one of the main advanced neurosurgical treatments for drug-resistant tremor. However, not every patient may be eligible for this procedure. Nowadays, various other functional neurosurgical procedures are available. In particular cases, radiofrequency thalamotomy, focused ultrasound and radiosurgery are proven alternatives to DBS. Besides, other DBS targets, such as the posterior subthalamic area (PSA) or the dentato-rubro-thalamic tract (DRT), may be appraised as well. In this review, the clinical characteristics and pathophysiology of tremor syndromes, as well as long-term outcomes of DBS in different targets, will be summarized. The effectiveness and safety of lesioning procedures will be discussed, and an evidence-based clinical treatment approach for patients with drug-resistant tremor will be presented. Lastly, the future directions in the treatment of severe tremor syndromes will be elaborated.

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