scholarly journals Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex

2021 ◽  
Author(s):  
Sofie Louise Valk ◽  
Ting Xu ◽  
Casey Paquola ◽  
Bo-yong Park ◽  
Richard AI Bethlehem ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Social Cognition ◽  
Structure Function ◽  
Brain Structure ◽  
Meta Analysis ◽  
Behavioral Flexibility ◽  
Structure And Function ◽  
And Function ◽  
And Behavior ◽  
Intrinsic Function

Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in non-human primates had a similar spatial distribution, but we observed an increased coupling between structure and function in association regions in macaques relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social cognition and autobiographical memory. Our findings establish the genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex, culturally embedded forms of cognition.

Cognitive Neuroscience Approaches to Personality Disorders

2018 ◽  
Author(s):  
Andrew Poppe ◽  
Angus W. MacDonald III
Keyword(s):  
Personality Disorders ◽  
Cognitive Neuroscience ◽  
Brain Structure ◽  
Molecular Genetic ◽  
Structure And Function ◽  
Neural Processes ◽  
Brain Structure And Function ◽  
And Function ◽  
And Behavior

This chapter describes a cognitive neuroscience approach to understanding the psychological and neural processes that underlie personality and behavior. It explicates the utility of the cognitive neuroscience approach and the fundamental principles of the methods and how to interpret the findings. The chapter reviews the different neuroimaging tools and approaches that can be used to investigate brain structure and function. In doing so, it provides detailed information about what each method measures and how issues to consider when evaluating these measurements and their functional significance. The chapter provides the reader an appreciation of how understanding brain structure and function in vivo can serve as a bridge between molecular/genetic and symptom-based data to enrich the pathophysiology of personality disorders.

BRAIN STRUCTURE AND FUNCTION CORRELATES OF GENERAL AND SOCIAL COGNITION

2007 ◽  
Vol 06 (01) ◽  
pp. 35-74 ◽  
Author(s):  
DONALD L. ROWE ◽  
NICHOLAS J. COOPER ◽  
BELINDA J. LIDDELL ◽  
C. RICHARD CLARK ◽  
EVIAN GORDON ◽  
...  
Keyword(s):  
Social Cognition ◽  
Brain Structure ◽  
Structure And Function ◽  
Brain Structure And Function ◽  
And Function

scholarly journals The Meditative Mind: A Comprehensive Meta-Analysis of MRI Studies

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Maddalena Boccia ◽  
Laura Piccardi ◽  
Paola Guariglia
Keyword(s):  
Brain Structure ◽  
Meta Analysis ◽  
Self Regulation ◽  
Likelihood Estimation ◽  
Relevant Information ◽  
Structure And Function ◽  
Meditation Practice ◽  
Positive Effects ◽  
Brain Structure And Function ◽  
And Function

Over the past decade mind and body practices, such as yoga and meditation, have raised interest in different scientific fields; in particular, the physiological mechanisms underlying the beneficial effects observed in meditators have been investigated. Neuroimaging studies have studied the effects of meditation on brain structure and function and findings have helped clarify the biological underpinnings of the positive effects of meditation practice and the possible integration of this technique in standard therapy. The large amount of data collected thus far allows drawing some conclusions about the neural effects of meditation practice. In the present study we used activation likelihood estimation (ALE) analysis to make a coordinate-based meta-analysis of neuroimaging data on the effects of meditation on brain structure and function. Results indicate that meditation leads to activation in brain areas involved in processing self-relevant information, self-regulation, focused problem-solving, adaptive behavior, and interoception. Results also show that meditation practice induces functional and structural brain modifications in expert meditators, especially in areas involved in self-referential processes such as self-awareness and self-regulation. These results demonstrate that a biological substrate underlies the positive pervasive effect of meditation practice and suggest that meditation techniques could be adopted in clinical populations and to prevent disease.

Structure, Function, and Tort Law

2020 ◽  
Vol 13 (1) ◽  
pp. 31-79
Author(s):  
Dan Priel
Keyword(s):  
Structure Function ◽  
Tort Law ◽  
Structure And Function ◽  
Vicarious Liability ◽  
Causal Uncertainty ◽  
Popular View ◽  
And Function

AbstractA popular view among tort theorists is that an explanation of tort law must take account its “structure,” since this structure constitutes the law’s “self-understanding.” This view is used to both criticize competing functional accounts of tort law, especially economic ones, that are said to ignore tort law’s structure, and, more constructively, as a basis for explaining various tort doctrines. In this essay, I consider this argument closely and conclude that it is faulty. To be valid, one needs a non-question begging way of identifying the essence of tort law. I argue that law’s “self-understanding” can only make sense if it means the understanding of certain people. Examining those, I conclude that the claim of structuralists is false, for there are many people who take its function to be central. I then further show that if one wishes to understand the development of tort law’s doctrine one must take both structure and function into account. I demonstrate this claim by examining the development of the doctrine dealing with causal uncertainty and vicarious liability.

Effects Of Exercise-induced Hypohydration On Brain Structure And Function, A MRI Study

2017 ◽  
Vol 49 (5S) ◽  
pp. 824 ◽  
Author(s):  
X. r. Tan ◽  
Ivan C. C. Low ◽  
Mary C. Stephenson ◽  
T. Kok ◽  
Heinrich W. Nolte ◽  
...  
Keyword(s):  
Brain Structure ◽  
Structure And Function ◽  
Brain Structure And Function ◽  
Exercise Induced ◽  
Mri Study ◽  
And Function
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