scholarly journals Electrochemical Detection of Adrenaline and Hydrogen Peroxide on Carbon Nanotube Electrodes

2021 ◽  
Author(s):  
Gaurang Khot ◽  
Mohsin Kaboli ◽  
Tansu Celikel ◽  
Neil Shirtcliffe
Keyword(s):  
Carbon Nanotubes ◽  
Hydrogen Peroxide ◽  
Carbon Nanotube ◽  
Electrochemical Detection ◽  
Electrochemical Sensors ◽  
Carbon Electrodes ◽  
Cyclic Voltammetric ◽  
Highly Sensitive

Adrenaline and hydrogen peroxide have neuromodulatory functions in the brain.Considerable interest exists in developing electrochemical sensors that can detect their levels in vivo due to their important biochemical roles. Challenges associated with electrochemical detection of hydrogen peroxide and adrenaline are that the oxidation of these molecules usually requires highly oxidising potentials (beyond 1.4V vs Ag/AgCl) where electrode damage and biofouling are likely and the signals of adrenaline, hydrogen peroxide and adenosine overlap. To address these issues we fabricated pyrolysed carbon electrodes coated with oxidised carbon nanotubes (CNTs). Using these electrodes for fast-scan cyclic voltammetric (FSCV) measurements showed that the electrode offers reduced overpotentials compared with graphite and improved resistance to biofouling. The Adrenaline peak is reached at 0.75 V and reduced back at -0.2 V while hydrogen peroxide is detected at 0.85V on this electrode. The electrodes are highly sensitive with a sensitivity of16nA microM-1 for Adrenaline and 11nA microM-1 for hydrogen peroxide on an 80 micro m2 electrode. They are also suitable to distinguish between adrenaline, hydrogen peroxide and adenosine thus these probes can be used for multimodal detection of analytes.

scholarly journals Electrochemical detection of adrenaline and hydrogen peroxide on carbon nanotube electrodes

2022 ◽  
pp. 1-7
Author(s):  
Gaurang Khot ◽  
Mohsen Kaboli ◽  
Tansu Celikel ◽  
Neil Shirtcliffe
Keyword(s):  
Hydrogen Peroxide ◽  
Electrochemical Detection ◽  
Electrode Materials ◽  
Electrochemical Sensors ◽  
Carbon Electrodes ◽  
Peroxide Oxidation ◽  
Cyclic Voltammetric ◽  
Highly Sensitive ◽  
The Brain

Adrenaline and hydrogen peroxide have neuromodulatory functions in the brain and peroxide is also formed during reaction of adrenaline. Considerable interest exists in developing electrochemical sensors that can detect their levels in vivo due to their important biochemical roles. Challenges associated with electrochemical detection of hydrogen peroxide and adrenaline are that the oxidation of these molecules usually requires highly oxidising potentials (beyond 1.4 V vs Ag/AgCl) where electrode damage and biofouling are likely and the signals of adrenaline, hydrogen peroxide and adenosine overlap on most electrode materials. To address these issues we fabricated pyrolysed carbon electrodes coated with oxidised carbon nanotubes (CNTs). Using these electrodes for fast-scan cyclic voltammetric (FSCV) measurements showed that the electrode offers reduced overpotentials compared with graphite and improved resistance to biofouling. Adrenaline oxidises on this electrode at 0.75(±0.1) V and reduces back at −0.2(±0.1) V while hydrogen peroxide oxidation is detected at 0.85(±0.1) V on this electrode. The electrodes are highly sensitive with a sensitivity of 16 nA µM−1 for Adrenaline and 11 nA µM−1 for hydrogen peroxide on an 80 µm2 electrode. They are also suitable to distinguish between adrenaline, hydrogen peroxide and adenosine thus these probes can be used for multimodal detection of analytes.

A web of poly(bisbenzimidazolatocopper(II)) around multiwalled carbon nanotubes for the electrochemical detection of hydrogen peroxide

2021 ◽  
Author(s):  
Kothandaraman Ramanujam ◽  
Tamilselvi Gurusamy ◽  
Rajendran Rajaram ◽  
Raja Murugan
Keyword(s):  
Carbon Nanotubes ◽  
Hydrogen Peroxide ◽  
Carbon Nanotube ◽  
Electrochemical Detection ◽  
Glassy Carbon ◽  
Electrochemical Determination ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Multiwalled Carbon

The present work focuses on the electrochemical determination of hydrogen peroxide (H2O2), using a poly(bisbenzimidazolatocopper(II)) coordinated multiwalled carbon nanotube modified glassy carbon electrode (MWCNT/(BIM-Cu2+)n@GCE). The physical characterization techniques point to...

scholarly journals Simultaneous Detection of Dopamine and Serotonin with carbon-based electrodes

2021 ◽  
Author(s):  
Gaurang Khot ◽  
Neil James Shirtcliffe ◽  
Tansu Celikel
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotubes ◽  
Electrochemical Sensors ◽  
Simultaneous Detection ◽  
Carbon Electrodes ◽  
Oxidation Peak ◽  
Gaseous Species ◽  
Fast Scan Cyclic Voltammetry ◽  
Biologically Relevant

Graphite-based materials, like pyrolyzed carbon electrodes, are widely used as implantable electrochemical sensors, for the detection of neurotransmitters, neuromodulators, and gaseous species, thanks to their strong mechanical properties, superior electron-transfer kinetics, and in-vivo stability. Electrochemical properties of graphite can be improved by coating them with carbon nanotubes (CNTs) which improves sensitivity, selectivity, and resistance to biofouling. Although several types of electrodes have been developed to detect biologically relevant targets like monoamines, multiplexed sensing of dopamine and serotonin is not yet widely available. Herein we introduce pyrolyzed carbon electrodes coated with CNTs for fast scan cyclic voltammetry for simultaneous detection of dopamine and serotonin with a sensitivity of 52/microM and 5nA/microM, respectively. Serotonin shows a broad oxidation peak at 0.68V. When dopamine and serotonin are probed simultaneously at 10 Hz, dopamine oxidizes at 0.1V 0.1 and serotonin oxidizes at 0.78V and dopamine reduces at -0.35V and serotonin at 0.1V. Thus the sensors shows discrimination between dopamine and serotonin and are suitable for simultaneous detection of these monoamines. Keywords: Carbon nanotubes, Electrochemistry, Dopamine, Serotonin, Anti-fouling Surfaces

Fabrication of Carbon Nanotube Gas Sensor Using Step-Wise Dielectrophoretic Deposition Onto Interdigitated Pyrolyzed Carbon Electrodes

2021 ◽  
Author(s):  
Taajza Singleton ◽  
Lawrence Kulinsky
Keyword(s):  
Carbon Nanotubes ◽  
Electrical Conductivity ◽  
Carbon Nanotube ◽  
Gas Sensor ◽  
Carbon Electrodes ◽  
Proof Of Concept ◽  
Nitrogen Gas ◽  
Electrical Field ◽  
The Creation ◽  
Field Lines

Abstract Carbon nanotubes (CNTs) have been implemented in the creation of many micro- and nano-devices due to their physical properties such as large volume-to-surface area as well as their high thermal and electrical conductivity. The paper describes a novel dielectrophoretic step-wise deposition of CNTs (that alternates deposition of CNTs and drying steps) between the interdigitated fingers of carbon electrodes. Multiphysics simulation illustrates the physics of CNT alignment along the electrical field lines that forms a basis for dielectrophoretic deposition of CNTs. This fabrication methodology resulted in the creation of a proof-of-concept nitrogen gas sensor.

Highly sensitive compression sensors using three-dimensional printed polydimethylsiloxane/carbon nanotube nanocomposites

2019 ◽  
Vol 30 (8) ◽  
pp. 1216-1224 ◽  
Author(s):  
Mohammad Charara ◽  
Mohammad Abshirini ◽  
Mrinal C Saha ◽  
M Cengiz Altan ◽  
Yingtao Liu
Keyword(s):  
Carbon Nanotubes ◽  
Electron Microscope ◽  
Carbon Nanotube ◽  
Scanning Electron Microscope ◽  
Three Dimensional ◽  
Multi Walled Carbon Nanotube ◽  
Highly Sensitive ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Scanning Electron

This article presents three-dimensional printed and highly sensitive polydimethylsiloxane/multi-walled carbon nanotube sensors for compressive strain and pressure measurements. An electrically conductive polydimethylsiloxane/multi-walled carbon nanotube nanocomposite is developed to three-dimensional print compression sensors in a freestanding and layer-by-layer manner. The dispersion of multi-walled carbon nanotubes in polydimethylsiloxane allows the uncured nanocomposite to stand freely without any support throughout the printing process. The cross section of the compression sensors is examined under scanning electron microscope to identify the microstructure of nanocomposites, revealing good dispersion of multi-walled carbon nanotubes within the polydimethylsiloxane matrix. The sensor’s sensitivity was characterized under cyclic compression loading at various max strains, showing an especially high sensitivity at lower strains. The sensing capability of the three-dimensional printed nanocomposites shows minimum variation at various applied strain rates, indicating its versatile potential in a wide range of applications. Cyclic tests under compressive loading for over 8 h demonstrate that the long-term sensing performance is consistent. Finally, in situ micromechanical compressive tests under scanning electron microscope validated the sensor’s piezoresistive mechanism, showing the rearrangement, reorientation, and bending of the multi-walled carbon nanotubes under compressive loads, were the main reasons that lead to the piezoresistive sensing capabilities in the three-dimensional printed nanocomposites.

Facile and sensitive electrochemical detection of methyl parathion based on a sensing platform constructed by the direct growth of carbon nanotubes on carbon paper

RSC Advances ◽  
2016 ◽  
Vol 6 (63) ◽  
pp. 58771-58779 ◽  
Author(s):  
Xiaoyue Yue ◽  
Pengxian Han ◽  
Wenxin Zhu ◽  
Jianlong Wang ◽  
Lixue Zhang
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Electrochemical Detection ◽  
Methyl Parathion ◽  
Carbon Paper ◽  
Sensing Platform ◽  
Direct Growth ◽  
Paper Sensor

Facile and sensitive methyl parathion detection was achieved based on a novel carbon nanotube/carbon paper sensor.

Optical enzymatic detection of glucose based on hydrogen peroxide-sensitive HiPco carbon nanotubes

2006 ◽  
Vol 21 (11) ◽  
pp. 2817-2823 ◽  
Author(s):  
Chulho Song ◽  
Pehr E. Pehrsson ◽  
Wei Zhao
Keyword(s):  
Carbon Nanotubes ◽  
Hydrogen Peroxide ◽  
Carbon Nanotube ◽  
Near Infrared ◽  
Sodium Dodecyl ◽  
Enzymatic Reaction ◽  
Infrared Region ◽  
Infrared Spectral ◽  
Sensitivity And Selectivity ◽  
Enzymatic Detection

We recently observed that surfactant sodium dodecyl sulfate (SDS)-encased HiPco single-walled carbon nanotubes (SWNTs) respond optically to hydrogen peroxide (H2O2) in the near-infrared region. In this report, we demonstrate that SDS-encased SWNTs immobilized with glucose oxidase (GOx) can be used to optically detect an enzymatic reaction of glucose based on their H2O2 sensitivity as well as pH sensitivity. Only the enzymatic product H2O2 induces the SWNT near-infrared spectral changes in buffer solutions (pH = 6.0), but both H2O2 and gluconic acid products do this in unbuffered solutions. The SWNT optical response to glucose possesses sensitivity and selectivity similar to an electrochemical method using carbon nanotube nanoelectrode arrays. Our results suggest possible carbon nanotube-based optical tools for molecular recognition applications.

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