scholarly journals Naturalistic hyperscanning with wearable magnetoencephalography

2021 ◽  
Author(s):  
Niall Holmes ◽  
Molly Rea ◽  
Ryan M Hill ◽  
Elena Boto ◽  
Andrew Stuart ◽  
...  
Keyword(s):  
Functional Neuroimaging ◽  
Brain Activity ◽  
Poor Performance ◽  
Neural Substrates ◽  
High Fidelity ◽  
Neural Basis ◽  
Temporal Precision ◽  
Naturalistic Setting ◽  
New Generation ◽  
Subject Motion

The evolution of human cognitive function is reliant on complex social interactions which form the behavioural foundation of who we are. These social capacities are subject to dramatic change in disease and injury; yet their supporting neural substrates remain poorly understood. Hyperscanning employs functional neuroimaging to simultaneously assess brain activity in two individuals and offers the best means to understand the neural basis of social interaction. However, present technologies are limited, either by poor performance (low spatial/temporal precision) or unnatural scanning environment (claustrophobic scanners, with interactions via video). Here, we solve this problem by developing a new form of hyperscanning using wearable magnetoencephalography (MEG). This approach exploits quantum sensors for MEG signal detection, in combination with high-fidelity magnetic field control – afforded by a novel "matrix coil" system – to enable simultaneous scanning of two freely moving participants. We demonstrate our approach in a somatosensory task and an interactive ball game. Despite large and unpredictable subject motion, sensorimotor brain activity was delineated clearly in space and time, and correlation of the envelope of neuronal oscillations between people was demonstrated. In sum, unlike existing modalities, wearable-MEG combines high fidelity data acquisition and a naturalistic setting, which will facilitate a new generation of hyperscanning.

scholarly journals Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0244320
Author(s):  
Nasim Maleki ◽  
Edina Szabo ◽  
Lino Becerra ◽  
Eric Moulton ◽  
Steven J. Scrivani ◽  
...  
Keyword(s):  
Functional Neuroimaging ◽  
Brain Activity ◽  
Imaging Study ◽  
Brain Activation ◽  
Episodic Migraine ◽  
Pain Tolerance ◽  
Trigeminal Nucleus ◽  
Neural Basis ◽  
Noxious Heat ◽  
No Activation

In some patients, migraine attacks are associated with symptoms of allodynia which can be localized (cephalic) or generalized (extracephalic). Using functional neuroimaging and cutaneous thermal stimulation, we aimed to investigate the differences in brain activation of patients with episodic migraine (n = 19) based on their allodynic status defined by changes between ictal and interictal pain tolerance threshold for each subject at the time of imaging. In this prospective imaging study, differences were found in brain activity between the ictal and interictal visits in the brainstem/pons, thalamus, insula, cerebellum and cingulate cortex. Significant differences were also observed in the pattern of activation along the trigeminal pathway to noxious heat stimuli in no allodynia vs. generalized allodynia in the thalamus and the trigeminal nucleus but there were no activation differences in the trigeminal ganglion. The functional magnetic resonance imaging (fMRI) findings provide direct evidence for the view that in migraine patients who are allodynic during the ictal phase of their attacks, the spinal trigeminal nucleus and posterior thalamus become hyper-responsive (sensitized)–to the extent that they mediate cephalic and extracephalic allodynia, respectively. In addition, descending analgesic systems seem as “switched off” in generalized allodynia.

The Neural Basis of Successful Word Reading in Aphasia

2018 ◽  
Vol 30 (4) ◽  
pp. 514-525 ◽  
Author(s):  
Sara B. Pillay ◽  
William L. Gross ◽  
William W. Graves ◽  
Colin Humphries ◽  
Diane S. Book ◽  
...  
Keyword(s):  
Word Reading ◽  
Functional Neuroimaging ◽  
Semantic Network ◽  
Brain Activity ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Angular Gyrus ◽  
Bold Signal ◽  
Neural Basis ◽  
Successful Performance

Understanding the neural basis of recovery from stroke is a major research goal. Many functional neuroimaging studies have identified changes in brain activity in people with aphasia, but it is unclear whether these changes truly support successful performance or merely reflect increased task difficulty. We addressed this problem by examining differences in brain activity associated with correct and incorrect responses on an overt reading task. On the basis of previous proposals that semantic retrieval can assist pronunciation of written words, we hypothesized that recruitment of semantic areas would be greater on successful trials. Participants were 21 patients with left-hemisphere stroke with phonologic retrieval deficits. They read words aloud during an event-related fMRI paradigm. BOLD signals obtained during correct and incorrect trials were contrasted to highlight brain activity specific to successful trials. Successful word reading was associated with higher BOLD signal in the left angular gyrus. In contrast, BOLD signal in bilateral posterior inferior frontal cortex, SMA, and anterior cingulate cortex was greater on incorrect trials. These data show for the first time the brain regions where neural activity is correlated specifically with successful performance in people with aphasia. The angular gyrus is a key node in the semantic network, consistent with the hypothesis that additional recruitment of the semantic system contributes to successful word production when phonologic retrieval is impaired. Higher activity in other brain regions during incorrect trials likely reflects secondary engagement of attention, working memory, and error monitoring processes when phonologic retrieval is unsuccessful.

scholarly journals Towards a functional neuroanatomy of conscious perception and its modulation by volition: implications of human auditory neuroimaging studies

1998 ◽  
Vol 353 (1377) ◽  
pp. 1883-1888 ◽  
Author(s):  
◽  
D. A. Silbersweig ◽  
E. Stern
Keyword(s):  
Functional Neuroimaging ◽  
Brain Activity ◽  
Neural Substrates ◽  
Functional Neuroanatomy ◽  
Subcortical Structures ◽  
Sensory Stimuli ◽  
Sensory Awareness ◽  
Positron Emission ◽  
Neuroimaging Techniques

Conscious sensory perception and its modulation by volition are integral to human mental life. Functional neuroimaging techniques provide a direct means of identifying and characterizing in vivo the systems-level patterns of brain activity associated with such mental functions. In a series of positron emission tomography activation experiments, we and our colleagues have examined a range of normal and abnormal auditory states that, when contrasted, provide dissociations relevant to the question of the neural substrates of sensory awareness. These dissociations include sensory awareness in the presence and absence of external sensory stimuli, the transition from sensory unawareness to awareness (or vice versa) in the presence of sensory stimuli, and sensory awareness with and without volition. The auditory states studied include hallucinations, mental imagery, cortical deafness modulated by attention, and hearing modulated by sedation. The results of these studies highlight the distributed nature of the functional neuroanatomy that is sufficient, if not necessary, for sensory awareness. The probable roles of unimodal association (as compared with primary) cortices, heteromodal cortices, limbic/paralimbic regions and subcortical structures (such as the thalamus) are discussed. In addition, interactions between pre– and post–rolandic regions are examined in the context of top–down, volitional modulation of sensory awareness.

Neurogenetics of Resilience

2020 ◽  
Author(s):  
Adam Anderson ◽  
Hans Melo
Keyword(s):  
Functional Neuroimaging ◽  
Brain Activity ◽  
Activity Patterns ◽  
Poor Mental Health ◽  
Imaging Genetics ◽  
Synthetic Approach ◽  
Neural Basis ◽  
Fine Grained ◽  
Optimal Functioning ◽  
Methodological Considerations

Our ability to recover from a negative experiences has profound implications not only for mental disorder but also for healthy living; while some individuals are deeply affected by life stressors and develop poor mental health, others seem to overcome even major traumatic events quickly and effortlessly. Critically, individual differences in resilience reflect underlying differences in the neural and genetic mechanisms implemented by different individuals to cope with hardship. Recent advances in functional neuroimaging and molecular genetics have given rise to a synthetic approach referred to as Imaging Genetics with great potential to develop a more fine-grained neurobiological characterization of optimal human functioning. The goal of imaging genetics is to identify mid-level phenotypes, or endophenotypes, in the form of brain activity patterns that reveal genetic influences on specific cognitive and emotional neural processes in the path from genes to behavior, and disorder. Recent years have seen increasing interest in understanding the genetic and neural basis of resilience. In this context, optimal functioning is not defined as the absence of disease but rather as the characteristics and conditions that allow a person to live well, thrive, and flourish. In this chapter we introduce the imaging genetics approach by providing methodological considerations, and discussing relevant studies and future directions as they may relate to resilience and the field of positive psychology in general.

scholarly journals Meditation and the Brain in Health and Disease

2020 ◽  
Author(s):  
Kieran C. R. Fox ◽  
B. Rael Cahn
Keyword(s):  
Cognitive Aging ◽  
Functional Neuroimaging ◽  
Brain Activity ◽  
Well Being ◽  
Neural Substrates ◽  
Human Cognition ◽  
Psychiatric Disease ◽  
Positron Emission ◽  
Health And Disease ◽  
Pet Scans

The aim of this chapter is to provide an accessible introduction to the neuroscience of meditation. First, a review of studies examining the relationship between meditation and alterations in the structure of the brain’s grey and white matter (so-called morphometric neuroimaging) is offered. Next, the chapter discusses findings from functional neuroimaging methods, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) scans, and what they have taught us about the brain’s patterns of activity during different forms of meditation, how meditation alters the brain’s response to various tasks and experiences, and how the expertise of long-term meditators might be harnessed to help us explore subtle aspects of human cognition. Third, the chapter reviews electrophysiological methods of measuring brain activity during meditation, such as electroencephalography (EEG), and how these findings relate to what we have learned from morphometric and functional neuroimaging. Finally, there is a discussion of the implications of this research and of meditation more generally for brain health and psychological well-being. Specifically, the discussion focuses on how meditation might offset the deficits related to cognitive aging, as well as help ameliorate the symptoms and underlying neural substrates associated with neurodegenerative and psychiatric disease.

scholarly journals Meditation and the brain in health and disease

2018 ◽  
Author(s):  
Kieran Fox ◽  
B. Rael Cahn
Keyword(s):  
Cognitive Aging ◽  
Functional Neuroimaging ◽  
Brain Activity ◽  
Well Being ◽  
Neural Substrates ◽  
Human Cognition ◽  
Psychiatric Disease ◽  
Positron Emission ◽  
Health And Disease ◽  
Pet Scans

The aim of this chapter is to provide an accessible introduction to the neuroscience of meditation. First, we review studies examining the relationship between meditation and alterations in the structure of the brain’s grey and white matter (so-called morphometric neuroimaging). Next, we discuss findings from functional neuroimaging methods, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) scans, and what they have taught us about the brain’s patterns of activity during different forms of meditation, how meditation alters the brain’s response to various tasks and experiences, and how the expertise of long-term meditators might be harnessed to help us explore subtle aspects of human cognition. Third, we review electrophysiological methods of measuring brain activity during meditation, such as electroencephalography (EEG), and how these findings relate to what we have learned from morphometric and functional neuroimaging. Finally, we discuss the implications of this research and of meditation more generally for brain health and psychological well-being. Specifically, we focus on how meditation might ameliorate the deficits related to cognitive aging, as well as help ameliorate the symptoms and underlying neural substrates associated with neurodegenerative and psychiatric disease.

Behavior in the Brain

2010 ◽  
Vol 24 (2) ◽  
pp. 76-82 ◽  
Author(s):  
Martin M. Monti ◽  
Adrian M. Owen
Keyword(s):  
Motor Behavior ◽  
Functional Neuroimaging ◽  
Brain Activity ◽  
Motor Output ◽  
The Unconscious ◽  
Ethical Implications ◽  
Brain Responses ◽  
Minimally Conscious ◽  
Brain Insults ◽  
Brain Behavior

Recent evidence has suggested that functional neuroimaging may play a crucial role in assessing residual cognition and awareness in brain injury survivors. In particular, brain insults that compromise the patient’s ability to produce motor output may render standard clinical testing ineffective. Indeed, if patients were aware but unable to signal so via motor behavior, they would be impossible to distinguish, at the bedside, from vegetative patients. Considering the alarming rate with which minimally conscious patients are misdiagnosed as vegetative, and the severe medical, legal, and ethical implications of such decisions, novel tools are urgently required to complement current clinical-assessment protocols. Functional neuroimaging may be particularly suited to this aim by providing a window on brain function without requiring patients to produce any motor output. Specifically, the possibility of detecting signs of willful behavior by directly observing brain activity (i.e., “brain behavior”), rather than motoric output, allows this approach to reach beyond what is observable at the bedside with standard clinical assessments. In addition, several neuroimaging studies have already highlighted neuroimaging protocols that can distinguish automatic brain responses from willful brain activity, making it possible to employ willful brain activations as an index of awareness. Certainly, neuroimaging in patient populations faces some theoretical and experimental difficulties, but willful, task-dependent, brain activation may be the only way to discriminate the conscious, but immobile, patient from the unconscious one.

Emotional Reactivity to Visual Content as Revealed by ERP Component Clustering

2015 ◽  
Vol 29 (4) ◽  
pp. 135-146 ◽  
Author(s):  
Miroslaw Wyczesany ◽  
Szczepan J. Grzybowski ◽  
Jan Kaiser
Keyword(s):  
Emotional Reactivity ◽  
Brain Activity ◽  
Affective State ◽  
Occipital Lobe ◽  
Stimulus Onset ◽  
Emotional States ◽  
Neural Basis ◽  
Temporoparietal Junction ◽  
The Right ◽  
The Impact

Abstract. In the study, the neural basis of emotional reactivity was investigated. Reactivity was operationalized as the impact of emotional pictures on the self-reported ongoing affective state. It was used to divide the subjects into high- and low-responders groups. Independent sources of brain activity were identified, localized with the DIPFIT method, and clustered across subjects to analyse the visual evoked potentials to affective pictures. Four of the identified clusters revealed effects of reactivity. The earliest two started about 120 ms from the stimulus onset and were located in the occipital lobe and the right temporoparietal junction. Another two with a latency of 200 ms were found in the orbitofrontal and the right dorsolateral cortices. Additionally, differences in pre-stimulus alpha level over the visual cortex were observed between the groups. The attentional modulation of perceptual processes is proposed as an early source of emotional reactivity, which forms an automatic mechanism of affective control. The role of top-down processes in affective appraisal and, finally, the experience of ongoing emotional states is also discussed.

scholarly journals The Neural Basis of Vivid Memory Is Patterned on Perception

2012 ◽  
Vol 24 (9) ◽  
pp. 1867-1883 ◽  
Author(s):  
Bradley R. Buchsbaum ◽  
Sabrina Lemire-Rodger ◽  
Candice Fang ◽  
Hervé Abdi
Keyword(s):  
Brain Activity ◽  
Sensory Perception ◽  
Direct Perception ◽  
Neural Basis ◽  
Activation Patterns ◽  
Short Video ◽  
Initial Perception ◽  
Experiential Quality ◽  
High Degree

When we have a rich and vivid memory for a past experience, it often feels like we are transported back in time to witness once again this event. Indeed, a perfect memory would exactly mimic the experiential quality of direct sensory perception. We used fMRI and multivoxel pattern analysis to map and quantify the similarity between patterns of activation evoked by direct perception of a diverse set of short video clips and the vivid remembering, with closed eyes, of these clips. We found that the patterns of distributed brain activation during vivid memory mimicked the patterns evoked during sensory perception. Using whole-brain patterns of activation evoked by perception of the videos, we were able to accurately classify brain patterns that were elicited when participants tried to vividly recall those same videos. A discriminant analysis of the activation patterns associated with each video revealed a high degree (explaining over 80% of the variance) of shared representational similarity between perception and memory. These results show that complex, multifeatured memory involves a partial reinstatement of the whole pattern of brain activity that is evoked during initial perception of the stimulus.

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