scholarly journals Fetal programming by sodium saccharin and damage on male offspring reproductive

2021 ◽  
Author(s):  
Alana Rezende Godoi ◽  
Vanessa Caroline Fioravante ◽  
Beatriz Melo Santos ◽  
Francisco Eduardo Martinez ◽  
Patricia Fernanda Felipe Pinheiro
Keyword(s):  
Fetal Programming ◽  
Sperm Count ◽  
Male Offspring ◽  
Reproductive Parameters ◽  
Saccharin Consumption ◽  
Sodium Saccharin ◽  
And Function ◽  
Tubular Diameter ◽  
Estradiol Concentration ◽  
Testis Structure

Male infertility is responsible for 20-70% of infertility in couples. We investigated the effects of fetal programming with sodium saccharin consumption in testis structure and function and in male offspring fertility. Feed intake and efficiency, organ and fat weight, quantification and expression of AR and PCNA proteins, sperm count and hormonal dosages were performed. Changes in consumption were found in the final weeks of the experiment. Decreases in the expression and quantification of AR and PCNA, tubular diameter and luminal volume, and increase in epithelial and interstitial relative volumes were observed. Lower sperm count and transit and lower estradiol concentration were also found. The consumption of sodium saccharin by the dams programmed the male offspring affecting the HPG axis with alterations in Sertoli cell proliferation, AR expression and quantification, and sperm count. We hypothesize that these changes may be due to the reduction of estradiol that caused the loosening of the tight junctions of the blood-testis-barrier (BTB), causing cell losses during spermatogenesis, also reflecting, under the decrease in tubular diameter with an increase in epithelial volume and consequent decrease in luminal volume. Sodium saccharin programming directly affected the reproductive parameters of male offspring and adult fertility.

scholarly journals Environmental and Nutritional Aspect in Male Infertility

1970 ◽  
Vol 10 (1) ◽  
pp. 16-19 ◽  
Author(s):  
Hamida Begum ◽  
ABM Moniruddin ◽  
Khairun Nahar
Keyword(s):  
Heavy Metals ◽  
Male Infertility ◽  
Sperm Count ◽  
Sperm Production ◽  
Male And Female ◽  
Exogenous Estrogen ◽  
Sperm Counts ◽  
And Function ◽  
Nutritional Aspect ◽  
Anatomical Defects

Male and female partner of a couple must be standard and fit to have the capacity to procreate. Studies confirm that male sperm counts are declining and environmental factors as pesticides, exogenous estrogen, heavy metals negatively impact spermatogenesis without any obvious anatomical defects. So, a number of nutritional therapies have been shown to improve sperm count and motility as carnitine, arginine, zinc, selenium and vitamin B12. Numerous anitioxidants have prove beneficial in treating male infertility as Vitamin C, Vitamin E, Glutathione and Coenzyme Q10. This article aims to highlight the correction of nutritional imbalances to encourage optimum sperm production and function, when there is idiopathic impaired spermatogenesis.   doi:10.3329/jom.v10i1.1997   J Medicine 2009; 10: 16-19   

scholarly journals Toxicity and Reproductive Parameters Impairment of Cypermethrin in Male Guinea Pig (Cavia porcellus)

2018 ◽  
Vol 6 (2) ◽  
pp. 130 ◽  
Author(s):  
Bertin Narcisse Vemo ◽  
Augustave Kenfack ◽  
Ferdinand Ngoula ◽  
Edouard Akono Nantia ◽  
Claude Cedric Njieudeu Ngaleu ◽  
...  
Keyword(s):  
Body Weight ◽  
Guinea Pig ◽  
Sperm Count ◽  
Prostatic Acid Phosphatase ◽  
Domestic Animals ◽  
Seminiferous Tubules ◽  
Reproductive Parameters ◽  
Serum Concentrations ◽  
Total Protein Level ◽  
Germinal Cells

Cypermethrin is a large spectrum action insecticide, globally employed to control pests in agriculture and some human and domestic animals ectoparasites. This study aimed to evaluate its toxicity and reproduction impairment in male guinea pig. Forty adult male guinea pigs were divided into 4 groups and orally submitted to 0, 92, 137.5 and 275 mg/kg body weight/day for 90 days. The weight of the liver increased significantly, while that of kidneys decreased significantly in treated animals compared to controls. Serum concentrations of creatinine, urea, ALAT, ASAT, total cholesterol, prostatic acid phosphatase increased significantly, while the testicular total protein level decreased significantly in groups given the insecticide relatively to the control. The testes weight, libido, serum level of testosterone, mobility, sperm count and the percentage of spermatozoa with entire plasma membrane decreased significantly in animals exposed to cypermethrin with reference to controls. The percentages of abnormal spermatozoa increased significantly in animals submitted to 137.5 or 275 mg/kg body weight (bw) of cypermethrin compared to control ones. On the testis histological sections of pesticide-treated animals, immature germinal cells were observed in the lumen of seminiferous tubules. Cypermethrin was toxic in male guinea pig and damaged reproductive parameters.

Exposure to cadmium during gestation and lactation affects development and function of Leydig cells in male offspring

2017 ◽  
Vol 33 (3) ◽  
pp. 351-360 ◽  
Author(s):  
Huajian Tian ◽  
Shaomin Chen ◽  
Yang Leng ◽  
Teng Li ◽  
Zengli Li ◽  
...  
Keyword(s):  
Leydig Cells ◽  
Male Offspring ◽  
And Function

scholarly journals Impact of thymoquinone supplementation on immobilisation stress-induced changes in reproductive characteristics of male mice

2014 ◽  
Vol 6 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Suzanah Abdul Rahman ◽  
Norul Athirah Mohamed Anwar ◽  
Shaik Sadak Basha ◽  
Saheera Kamarzaman
Keyword(s):  
Intraperitoneal Injection ◽  
Sperm Count ◽  
Reproductive Parameters ◽  
Group I ◽  
Testicular Weight ◽  
Significant Difference ◽  
Immobilisation Stress ◽  
Level Of Significance ◽  
Induced Changes ◽  
The Impact

The aim of the current study was to investigate changes in the reproductive parameters during stress and the impact of thymoquinone during the period. The effects of stress were measured through immobilisation stress on mice. Group I was administered normal saline daily via intraperitoneal injection while Groups II and III were subjected to 2 and 6 hours of immobilisation stress respectively. Groups IV and V were subjected to stress for 2 and 6 hours respectively followed by intraperitoneal injection of 10 mg/kg thymoquinone which was continued on alternate days. The level of significance was set at p<0.05 and statistical analysis showed significant difference in testicular weight of mice in groups II and III compared to the controls but no significant difference was obtained for sperm count between all groups. Sperm motility, however, was significantly different among the groups under stress for 2 and 6 hours and that of 6 hours with the treatment of thymoquinone when compared to the controls. The histology of the testes also indicated a few alterations in comparison to the controls in the germinal epithelium and spermatogenic pattern in groups III and V.

Comparative testis structure and function in three representative mice strains

2020 ◽  
Vol 382 (2) ◽  
pp. 391-404
Author(s):  
Carolina Felipe Alves de Oliveira ◽  
Nathalia de Lima e Martins Lara ◽  
Bárbara Ramalho Ladeira Cardoso ◽  
Luiz Renato de França ◽  
Gleide Fernandes de Avelar
Keyword(s):  
Structure And Function ◽  
And Function ◽  
Testis Structure

scholarly journals Group IVA phospholipase A2 regulates testosterone biosynthesis by murine Leydig cells and is required for timely sexual maturation

2011 ◽  
Vol 439 (3) ◽  
pp. 403-411 ◽  
Author(s):  
Shiro Kurusu ◽  
Adam Sapirstein ◽  
Harumi Sawada ◽  
Mitsumori Kawaminami ◽  
Joseph V. Bonventre
Keyword(s):  
Phospholipase A2 ◽  
Sexual Maturation ◽  
Sperm Count ◽  
Wild Type Mouse ◽  
Interstitial Cells ◽  
Testosterone Production ◽  
Camp Analogue ◽  
Group Iva ◽  
Testosterone Biosynthesis ◽  
And Function

In the present paper, we report that PLA2G4A (Group IVA phospholipase A2) is important in the development and function of rodent testes. Interstitial cells of rat testes had high PLA2 (phospholipase A2) activity that was very sensitive to the PLA2G4A-preferential inhibitor AACOCF3 (arachidonyl trifluoromethyl ketone). PLA2G4A protein was expressed primarily in the interstitial cells of wild-type mouse testes throughout maturation. Although Pla2g4a knockout (Pla2g4a−/−) male mice are fertile, their sexual maturation was delayed, as indicated by cauda epididymal sperm count and seminal vesicle development. Delayed function of Pla2g4a−/− mice testes was associated with histological abnormalities including disorganized architecture, swollen appearance and fewer interstitial cells. Basal secretion of testosterone was attenuated significantly and steroidogenic response to hCG (human chorionic gonadotropin) treatment was reduced in Pla2g4a−/− mice compared with their Pla2g4a+/+ littermates during the sexual maturation period. Chemical inhibition of PLA2G4A activity by AACOCF3 or pyrrophenone significantly reduced hCG-stimulated testosterone production in cultured rat interstitial cells. AACOCF3 inhibited forskolin- and cAMP analogue-stimulated testosterone production. These results provide the first evidence that PLA2G4A plays a role in male testes physiology and development. These results may have implications for the potential clinical use of PLA2G4A inhibitors.

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