scholarly journals Spindle - slow oscillation coupling correlates with memory performance and connectivity changes in a hippocampal network after sleep

2021 ◽  
Author(s):  
Lisa Marie Bastian ◽  
Anumita Samanta ◽  
Demetrius Ribeiro de Paula ◽  
Frederik Weber ◽  
Robby Schoenfeld ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Spatial Memory ◽  
Learning Strategies ◽  
Memory Consolidation ◽  
Resting State ◽  
Memory Performance ◽  
Slow Oscillation ◽  
Long Term Memory ◽  
Holistic Understanding ◽  
Hippocampal Network

After experiences are encoded, post-encoding reactivations during sleep have been proposed to mediate long-term memory consolidation. Spindle-slow oscillation coupling during NREM sleep is a candidate mechanism through which a hippocampal-cortical dialogue may strengthen a newly formed memory engram. Here, we investigated the role of fast spindle- and slow spindle-slow oscillation coupling in the consolidation of spatial memory in humans with a virtual water maze task involving allocentric and egocentric learning strategies. Furthermore, we analyzed how resting-state functional connectivity evolved across learning, consolidation, and retrieval of this task using a data-driven approach. Our results show task-related connectivity changes in the executive control network, the default mode network, and the hippocampal network at post-task rest. The hippocampal network could further be divided into two subnetworks of which only one showed modulation by sleep. Decreased functional connectivity in this subnetwork was associated with higher spindle-slow oscillation coupling power, which was also related to better memory performance at test. Overall, this study contributes to a more holistic understanding of the functional resting-state networks and the mechanisms during sleep associated to spatial memory consolidation.

scholarly journals A Cross-Syndrome Comparison of Sleep-Dependent Learning on a Cognitive Procedural Task

2019 ◽  
Vol 124 (4) ◽  
pp. 339-353 ◽  
Author(s):  
Anna Joyce ◽  
Catherine M. Hill ◽  
Annette Karmiloff-Smith ◽  
Dagmara Dimitriou
Keyword(s):  
Learning Strategies ◽  
Memory Consolidation ◽  
Sleep Problems ◽  
Long Term Memory ◽  
Educational Strategies ◽  
Night Time ◽  
Tower Of Hanoi ◽  
Procedural Task ◽  
Retention Intervals ◽  
Dependent Learning

Abstract Sleep plays a key role in the consolidation of newly acquired information and skills into long term memory. Children with Down syndrome (DS) and Williams syndrome (WS) frequently experience sleep problems, abnormal sleep architecture, and difficulties with learning; thus, we predicted that children from these clinical populations would demonstrate impairments in sleep-dependent memory consolidation relative to children with typical development (TD) on a cognitive procedural task: The Tower of Hanoi. Children with DS (n = 17), WS (n = 22) and TD (n = 34) completed the Tower of Hanoi task. They were trained on the task either in the morning or evening, then completed it again following counterbalanced retention intervals of daytime wake and night time sleep. Children with TD and with WS benefitted from sleep for enhanced memory consolidation and improved their performance on the task by reducing the number of moves taken to completion, and by making fewer rule violations. We did not find any large effects of sleep on learning in children with DS, suggesting that these children are not only delayed, but atypical in their learning strategies. Importantly, our findings have implications for educational strategies for all children, specifically considering circadian influences on new learning and the role of children's night time sleep as an aid to learning.

scholarly journals Incorporation of fragmented visuo-olfactory episodic memory into dreams and its association with memory performance

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
J. Plailly ◽  
M. Villalba ◽  
R. Vallat ◽  
A. Nicolas ◽  
P. Ruby
Keyword(s):  
Episodic Memory ◽  
Spatial Memory ◽  
Memory Consolidation ◽  
Memory Performance ◽  
Dream Content ◽  
The Other ◽  
Review Of The Literature ◽  
Comprehensive Review ◽  
Odor Recognition ◽  
With Memory

Abstract The question of a possible link between dream content and memory consolidation remains open. After a comprehensive review of the literature, we present novel findings from an experiment testing whether the incorporation of recently learned stimuli into dream reports is associated with improved post-sleep memory performance. Thirty-two high dream recallers freely explored new visuo-olfactory episodes for 3 consecutive days. During the nights following each non-explicit encoding, participants wore a wrist actimeter, and woke up at 5am and their usual waking time to record their dreams (intensity of all oneiric sensory perception was assessed using scales). A total of 120 dreams were reported and elements related to the encoding phase were identified in 37 of them, either learning-related (mainly visual- and rarely olfactory-related elements), or experiment-related (lab- or experimenters-related elements). On the 4th day, we found that participants with learning-related (n = 16) and participants with learning-related and/or experiment-related dreams (n = 21) had similar odor recognition and odor-evoked episodic memory with the other participants. However, they had significantly better visuo-spatial memory of the episodes in comparison to the other participants. Our results support the hypothesis that the learning phase is loosely incorporated into dreams and that this incorporation is associated with sleep related memory consolidation.

scholarly journals Exploration of a novel virtual environment improves memory consolidation in ADHD

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Valentin Baumann ◽  
Thomas Birnbaum ◽  
Carolin Breitling-Ziegler ◽  
Jana Tegelbeckers ◽  
Johannes Dambacher ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Virtual Environment ◽  
Memory Consolidation ◽  
Memory Performance ◽  
Word List ◽  
Long Term Memory ◽  
Typically Developing ◽  
Novel Environment ◽  
Memory Problems ◽  
Familiar Environment

AbstractExperimental evidence in rodents and humans suggests that long-term memory consolidation can be enhanced by the exploration of a novel environment presented during a vulnerable early phase of consolidation. This memory enhancing effect (behavioral tagging) is caused by dopaminergic and noradrenergic neuromodulation of hippocampal plasticity processes. In translation from animal to human research, we investigated whether behavioral tagging with novelty can be used to tackle memory problems observed in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). 34 patients with ADHD and 34 typically developing participants (age 9–15 years) explored either a previously familiarized or a novel virtual environment 45 min after they had learned a list of 20 words. Participants took a free recall test both immediately after learning the word list and after 24 h. Patients who explored a familiar environment showed significantly impaired memory consolidation compared to typically developing peers. Exploration of a novel environment led to significantly better memory consolidation in children and adolescents with ADHD. However, we did not observe a beneficial effect of novel environment exploration in typically developing participants. Our data rather suggested that increased exploration of a novel environment as well as higher feelings of virtual immersion compromised memory performance in typically developing children and adolescents, which was not the case for patients with ADHD. We propose that behavioral tagging with novel virtual environments is a promising candidate to overcome ADHD related memory problems. Moreover, the discrepancy between children and adolescents with and without ADHD suggests that behavioral tagging might only be able to improve memory consolidation for weakly encoded information.

scholarly journals Fast and slow cortical high frequency oscillations for cortico-cortical and cortico-hippocampal network consolidation during NonREM sleep

2019 ◽  
Author(s):  
Adrian Aleman-Zapata ◽  
Richard GM Morris ◽  
Lisa Genzel
Keyword(s):  
Memory Consolidation ◽  
High Frequency ◽  
Long Term Memory ◽  
Causality Analysis ◽  
Granger Causality Analysis ◽  
High Frequency Oscillations ◽  
New Information ◽  
Hippocampal Network ◽  
Nonrem Sleep

AbstractMemory reactivation during NonREM-ripples is thought to communicate new information to a systems-wide network. Cortical high frequency events have also been described that co-occur with ripples. Focusing on NonREM sleep after different behaviors, both hippocampal ripples and parietal high frequency oscillations were detected. A bimodal frequency distribution was observed in the parietal high frequency events, faster and slower, with increases in prefrontal directionality measured by Granger causality analysis specifically seen during the fast parietal oscillations. Furthermore, fast events activated prefrontal-parietal cortex whereas slow events activated hippocampal-parietal areas. Finally, there was a learning-induced increase in both number and size of fast high frequency events. These patterns were not seen after novelty exposure or foraging, but occurred after the learning of a new goal location in a maze. Disruption of either sleep or hippocampal ripples impaired long-term memory consistent with these having a role in memory consolidation.

scholarly journals Functional Connectivity of Resting State as a Biomarker for Working Memory Performance

2016 ◽  
Vol 10 ◽  
Author(s):  
Nese H�den ◽  
Soylu Can ◽  
Irak Metahan ◽  
Adanali Pinar ◽  
Akin Ata
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Resting State ◽  
Memory Performance

scholarly journals Temporal–prefrontal cortical network for discrimination of valuable objects in long-term memory

2018 ◽  
Vol 115 (9) ◽  
pp. E2135-E2144 ◽  
Author(s):  
Ali Ghazizadeh ◽  
Whitney Griggs ◽  
David A. Leopold ◽  
Okihide Hikosaka
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
High Capacity ◽  
Long Term Memory ◽  
Gaze Behavior ◽  
Resting State Functional Connectivity ◽  
Term Memory ◽  
Term Retention ◽  
Long Term Retention

Remembering and discriminating objects based on their previously learned values are essential for goal-directed behaviors. While the cerebral cortex is known to contribute to object recognition, surprisingly little is known about its role in retaining long-term object–value associations. To address this question, we trained macaques to arbitrarily associate small or large rewards with many random fractal objects (>100) and then used fMRI to study the long-term retention of value-based response selectivity across the brain. We found a pronounced long-term value memory in core subregions of temporal and prefrontal cortex where, several months after training, fractals previously associated with high reward (“good” stimuli) elicited elevated fMRI responses compared with those associated with low reward (“bad” stimuli). Similar long-term value-based modulation was also observed in subregions of the striatum, amygdala, and claustrum, but not in the hippocampus. The value-modulated temporal–prefrontal subregions showed strong resting-state functional connectivity to each other. Moreover, for areas outside this core, the magnitude of long-term value responses was predicted by the strength of resting-state functional connectivity to the core subregions. In separate testing, free-viewing gaze behavior indicated that the monkeys retained stable long-term memory of object value. These results suggest an implicit and high-capacity memory mechanism in the temporal–prefrontal circuitry and its associated subcortical regions for long-term retention of object-value memories that can guide value-oriented behavior.

Global functional connectivity is related to age and memory performance in healthy adults: A resting-state fMRI study

2013 ◽  
Vol 333 ◽  
pp. e726 ◽  
Author(s):  
L.K. Ferreira ◽  
A.C.B. Regina ◽  
N. Kovacevic ◽  
M.D.G.M. Martin ◽  
E. Amaro ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Memory Performance ◽  
Resting State Fmri ◽  
Healthy Adults ◽  
Fmri Study
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