Inflammaging in Major Depressive Disorder: Associations between markers of inflammation and brain ageing in depression across two large community-based cohorts

Background: Major Depressive Disorder (MDD) is associated with accelerated ageing trajectories including functional markers of ageing, cellular ageing and markers of poor brain health. The biological mechanisms underlying these associations remain poorly understood. Chronic inflammation is also associated with advanced ageing; however, the degree to which long-term inflammation plays a role in ageing in MDD remains unclear, partly due to difficulties differentiating long-term inflammation from acute cross-sectional measures. Methods: Here, we use a longer-term measure of inflammation: a DNA methylation-based marker of C-reactive protein (DNAm CRP), in a large cohort of individuals deeply phenotyped for MDD (Generation Scotland, GS, N=804). We investigate associations between DNAm CRP and serum CRP using linear modelling with two brain ageing neuroimaging-derived phenotypes: (i) a machine learning based measure of brain-predicted age difference (brain-PAD) and (ii) white matter hyperintensities (WMH). We then examine inflammation by depression interaction effects for these brain ageing phenotypes. We sought to replicate findings in an independent sample of older community-dwelling adults (Lothian Birth Cohort 1936, LBC1936; N=615). Results: DNAm CRP was significantly associated with increased brain-PAD (β=0.111, p=0.015), which was replicated in the independent sample with a similar significant effect size (β=0.114, p=0.012). There were no associations between the inflammation markers and WMH phenotypes in the GS-imaging sample, however in the LBC1936 sample, DNAm CRP was significantly associated with both Wahlund infratentorial (β=0.15, PFDR= 0.006) and Fazekas deep white matter hyperintensity scores (β= 0.116, PFDR=0.033). There were no interaction effects between inflammation and MDD in either cohort. Conclusions: This study found robust associations between a longer-term marker of inflammation and brain ageing as measured by brain-PAD, consistent across two large independent samples. However, we found no evidence for interaction effects between inflammation and MDD on any brain ageing phenotype in these community-based cohorts. These findings provide evidence that chronic inflammation is associated with increased brain ageing, which is not specific to MDD. Future work should investigate these relationships in clinical samples including with other inflammatory biomarkers and should furthermore aim to determine causal directionality.

Download Full-text

Long-Term Fine Particulate Matter Exposure and Major Depressive Disorder in a Community-Based Urban Cohort

Environmental Health Perspectives ◽

10.1289/ehp192 ◽

2016 ◽

Vol 124 (10) ◽

pp. 1547-1553 ◽

Cited By ~ 67

Author(s):

Kyoung-Nam Kim ◽

Youn-Hee Lim ◽

Hyun Joo Bae ◽

Myounghee Kim ◽

Kweon Jung ◽

...

Keyword(s):

Major Depressive Disorder ◽

Particulate Matter ◽

Depressive Disorder ◽

Fine Particulate Matter ◽

Community Based ◽

Major Depressive ◽

Fine Particulate ◽

Particulate Matter Exposure

Download Full-text

Geriatric Conditions and Functional Disability among a National Community-Dwelling Sample of Older Adults in India in 2017–2018

Geriatrics ◽

10.3390/geriatrics6030071 ◽

2021 ◽

Vol 6 (3) ◽

pp. 71

Author(s):

Supa Pengpid ◽

Karl Peltzer

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Chronic Conditions ◽

Sociodemographic Factors ◽

Community Dwelling ◽

Impaired Hearing ◽

Major Depressive ◽

Impaired Vision ◽

Geriatric Conditions ◽

Impaired Cognition

This study aimed to determine the prevalence of geriatric conditions and their association with disability in older community-dwelling adults in India. The cross-sectional sample consisted of 31,477 individuals (≥60 years) from the Longitudinal Ageing Study in India (LASI) Wave 1 in 2017–2018. Geriatric conditions assessed included injurious falls, impaired cognition, underweight, dizziness, incontinence, impaired vision and impaired hearing. More than two in five participants (44.3%) had no geriatric condition, 32.7% had one, 15.9% two and 7.1% had three or more geriatric conditions; 26.9% were underweight, 14.5% dizziness, 13.7% had impaired vision, 9.6% impaired hearing, 9.3% impaired cognition, 8.2% major depressive disorder, 5.7% injurious falls, 4.0% incontinence, and 7.4% had Activity of Daily Living (ADL) dependencies. In logistic regression analysis, adjusted by sociodemographic factors and the number of chronic conditions, we found a higher number of geriatric conditions, and a higher number of chronic conditions were associated with ADL dependencies. In a model adjusted for sociodemographic factors and the type of chronic conditions, we found that a higher number of geriatric conditions and heart disease, stroke, and bone or joint disorder were positively associated with ADL dependencies. The odds of ADL dependencies increased with impaired cognition, impaired vision, impaired hearing, and major depressive disorder. Impaired cognition, incontinence, impaired vision and major depressive disorder were positively associated with dressing, bathing, eating, transferring, and toileting dependency. In addition, impaired hearing was associated with transferring and toileting dependency. More than half of older adults in India had at least one geriatric condition. The prevalence of geriatric conditions was as high as the prevalence of chronic conditions, which in some cases were associated with disability. Geriatric conditions should be included in health care management.

Download Full-text

Major Depressive Disorder With Anger Attacks and Subcortical MRI White Matter Hyperintensities

The Journal of Nervous and Mental Disease ◽

10.1097/01.nmd.0000253820.69362.87 ◽

2007 ◽

Vol 195 (2) ◽

pp. 175-178 ◽

Cited By ~ 16

Author(s):

Dan V. Iosifescu ◽

Perry F. Renshaw ◽

Darin D. Dougherty ◽

In Kyoon Lyoo ◽

Ho Kyu Lee ◽

...

Keyword(s):

Major Depressive Disorder ◽

White Matter ◽

Depressive Disorder ◽

White Matter Hyperintensities ◽

Major Depressive ◽

Anger Attacks

Download Full-text

The Long-Term Effects of Mindfulness-Based Cognitive Therapy as a Relapse Prevention Treatment for Major Depressive Disorder

Behavioural and Cognitive Psychotherapy ◽

10.1017/s135246581000010x ◽

2010 ◽

Vol 38 (5) ◽

pp. 561-576 ◽

Cited By ~ 42

Author(s):

Kate L. Mathew ◽

Hayley S. Whitford ◽

Maura A. Kenny ◽

Linley A. Denson

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Cognitive Therapy ◽

Relapse Prevention ◽

Mindfulness Practice ◽

Long Term Effects ◽

Major Depressive ◽

Strong Negative Correlation ◽

Group 3

Background: Mindfulness-based Cognitive Therapy (MBCT) is a relapse prevention treatment for major depressive disorder. Method: An observational clinical audit of 39 participants explored the long-term effects of MBCT using standardized measures of depression (BDI-II), rumination (RSS), and mindfulness (MAAS). Results: MBCT was associated with statistically significant reductions in depression from pre to post treatment. Gains were maintained over time (Group 1, 1–12 months, p = .002; Group 2, 13–24 months, p = .001; Group 3, 25–34 months, p = .04). Depression scores in Group 3 did begin to worsen, yet were still within the mild range of the BDI-II. Treatment variables such as attendance at “booster” sessions and ongoing mindfulness practice correlated with better depression outcomes (p = .003 and p = .03 respectively). There was a strong negative correlation between rumination and mindful attention (p < .001), consistent with a proposed mechanism of metacognition in the efficacy of MBCT. Conclusion: It is suggested that ongoing MBCT skills and practice may be important for relapse prevention over the longer term. Larger randomized studies of the mechanisms of MBCT with longer follow-up periods are recommended.

Download Full-text