scholarly journals Safety of the single-dose Ad26.CoV2.S vaccine among healthcare workers in the phase 3b Sisonke study in South Africa

2021 ◽  
Author(s):  
Simbarashe Takuva ◽  
Azwidhwi Takalani ◽  
Ishen Seocharan ◽  
Nonhlanhla Yende-Zuma ◽  
Tarylee Reddy ◽  
...  
Keyword(s):  
South Africa ◽  
Health Care ◽  
Single Dose ◽  
Safety Data ◽  
Text Messages ◽  
Post Vaccination ◽  
Care Workers ◽  
Continued Use ◽  
National Databases ◽  
Site Pain

Background: The Sisonke openlabel phase 3b implementation study aimed to assess the safety and effectiveness of the Janssen Ad26.CoV2.S vaccine among health care workers (HCWs) in South Africa. Here, we present the safety data. Methods: We monitored adverse events (AEs) at vaccination sites, through self reporting triggered by text messages after vaccination, health care provider reports and by active case finding. The frequency and incidence rate of non serious and serious AEs were evaluated from day of first vaccination (17 February 2021) until 28 days after the final vaccination (15 June 2021). COVID 19 breakthrough infections, hospitalisations and deaths were ascertained via linkage of the electronic vaccination register with existing national databases. Findings: Of 477,234 participants, 10,279 (2.2%) reported AEs, of which 139 (1.4%) were serious. Women reported more AEs than men (2.3% vs. 1.6%). AE reports decreased with increasing age (3.2% for 18 to 30, 2.1% for 31 to 45, 1.8% for 46 to 55 and 1.5% in >55 year olds). Participants with previous COVID 19 infection reported slightly more AEs (2.6% vs. 2.1%). The commonest reactogenicity events were headache and body aches, followed by injection site pain and fever, and most occurred within 48 hours of vaccination. Two cases of Thrombosis with Thrombocytopenia Syndrome and four cases of Guillain Barre Syndrome were reported post-vaccination. Serious AEs and AEs of special interest including vascular and nervous system events, immune system disorders and deaths occurred at lower than the expected population rates. Interpretation: The single-dose Ad26.CoV2.S vaccine had an acceptable safety profile supporting the continued use of this vaccine in our setting.

scholarly journals Effectiveness of COVID-19 Vaccines: Eight Months Post Single Dose Vaccination

2021 ◽  
Author(s):  
Naif Khalaf Alharbi ◽  
Jaffar A. Al-Tawfiq ◽  
Suliman Alghnam ◽  
Amal Alwehaibe ◽  
Abrar Alasmari ◽  
...  
Keyword(s):  
Single Dose ◽  
Medical Records ◽  
Real World Data ◽  
Kingdom Of Saudi Arabia ◽  
Post Vaccination ◽  
Vaccine Type ◽  
National Databases ◽  
Site Pain ◽  
Saudi Male

Objectives: To describe the real-world data on the effectiveness of Pfizer-BioNtech BNT162b2 and AstraZeneca-Oxford AZD1222 vaccines against COVID-19 in a large cohort in the Kingdom of Saudi Arabia (KSA). Methods: A total of 18,543 subjects received a single-dose of either of the vaccines at one vaccination centre in KSA, and were followed up for three to eight months. Clinical data from medical records, adverse events (AEs) from a self-reporting system, and COVID-19 infection data from the national databases were retrieved and analysed. Results: Subjects median age was 33 years old with an average of 27.3 body mass index and the majority were male (60.1%). 92.17% of the subjects had no COVID-19 infection post-vaccination. Diabetes mellitus (p=0.0325), organ transplantation (p=0.0254), and morbid obesity (p=0.0014) were risk factors for infection post-vaccination. Unlike vaccine type, being Saudi, male, or obese was more likely to get the infection earlier. AE reports from 1084 subjects included injection site pain, fatigue, fever, myalgia, headache. Conclusion: Single-dose COVID-19 vaccines in KSA showed an effectiveness rate of 92.17% up to eight months follow-up. The rate for AZD1222 was higher than what have been previously reported. Side effects and AEs were within what has been reported in clinical trials.

scholarly journals A mixed reception: perceptions of pregnant adolescents’ experiences with health care workers in Cape Town, South Africa

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Ronel Sewpaul ◽  
Rik Crutzen ◽  
Natisha Dukhi ◽  
Derrick Sekgala ◽  
Priscilla Reddy
Keyword(s):  
South Africa ◽  
Health Care ◽  
Antenatal Care ◽  
Health Care Workers ◽  
Cape Town ◽  
Pregnant Adolescents ◽  
High Quality ◽  
Care Workers ◽  
Antenatal Clinics ◽  
Antenatal Services

Abstract Background Maternal mortality among adolescent mothers in South Africa is higher than many middle-income countries. This is largely attributable to conditions that can be prevented or managed by high quality antenatal care. The way in which pregnant adolescents are treated at antenatal clinics influences their timely utilization of antenatal services. This qualitative study reports on the experiences of pregnant adolescents with health care workers when accessing antenatal care. Methods Pregnant girls aged 13–19 (n = 19) who attended public health care facilities that provide Basic Antenatal Care (BANC) services in Cape Town, South Africa were recruited. Four face to face in-depth interviews and four mini focus group discussions were undertaken, facilitated by a topic guide. Thematic analyses were used to analyse the data. Results Experiences that reinforce antenatal attendance, such as respectful and supportive treatment, were outweighed by negative experiences, such as victimization; discrimination against being pregnant at a young age; experiencing disregard and exclusion; inadequate provision of information about pregnancy, health and childbirth; clinic attendance discouragement; and mental health turmoil. Conclusions There is evidence of a discordant relationship between the health care workers and the pregnant adolescents. Adolescents feel mistreated and discriminated against by the health care workers, which in turn discourages their attendance at antenatal clinics. Maternal health care workers need to receive support and regular training on the provision of youth friendly antenatal care and be regularly evaluated, to promote the provision of fair and high quality antenatal services for adolescent girls.

scholarly journals Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Amiya A. Ahmed ◽  
Megan Grammatico ◽  
Anthony P. Moll ◽  
Sipho Malinga ◽  
Philile Makhunga ◽  
...  
Keyword(s):  
South Africa ◽  
Health Care ◽  
Health Care Workers ◽  
Preventive Therapy ◽  
Rural South ◽  
Factors Associated ◽  
Care Workers ◽  
Prescription Rates ◽  
Rural South Africa

scholarly journals Traditional healers and cancer prevention

Curationis ◽  
2000 ◽  
Vol 23 (3) ◽  
Author(s):  
M Steyn ◽  
A Muller
Keyword(s):  
South Africa ◽  
Health Care ◽  
Health Education ◽  
Health Care Workers ◽  
Traditional Healers ◽  
Basic Knowledge ◽  
Care Workers ◽  
Prevention Of Cancer ◽  
Knowledge Of Cancer ◽  
Provide Health Education

The increase in the incidence of cancer in South Africa necessitates the expansion of preventative efforts. This study shows that traditional healers in Atteridgeville are consulted by a range of people in their communities, have a basic knowledge of cancer, provide health education to their patients and are willing to participate in cancer preventative strategies. They are therefore ideally suited to augment the services of westernized health care workers. The issue of professionalization is explored and a procedure is suggested whereby the training of traditional healers can be enhanced so as to facilitate their professionalization and their collaboration with other health care workers in the prevention of cancer.

When roles within interpreter-mediated psychiatric consultations speak louder than words

2020 ◽  
pp. 136346152093376 ◽  
Author(s):  
Sanja Kilian ◽  
Leslie Swartz ◽  
Xanthe Hunt ◽  
Ereshia Benjamin ◽  
Bonginkosi Chiliza
Keyword(s):  
South Africa ◽  
Health Care ◽  
Health Care Workers ◽  
Ad Hoc ◽  
Psychiatric Hospitals ◽  
Best Interests ◽  
Western Cape ◽  
Structured Interviews ◽  
Care Workers ◽  
Professional Interpreting

In South Africa, clinicians working in public psychiatric hospitals are mainly fluent in English and Afrikaans, while the majority of patients are not proficient in these languages. Due to a lack of professional interpreting services, informal, ad hoc interpreters are commonly employed in public psychiatric hospitals. We collected data on language practices in public psychiatric care in South Africa, and provide a detailed account of what happens when bilingual health care workers and cleaners haphazardly take on the additional role of interpreter. Data were collected during 2010 at a public psychiatric hospital in the Western Cape, South Africa. Thirteen interpreter-mediated psychiatric consultations were video-recorded, and 18 audio-recorded semi-structured interviews were conducted with the interpreters and clinicians who participated in the interpreter-mediated psychiatric consultations. Patients were proficient in isiXhosa (one of the 11 official languages of South Africa), the clinicians (all registrars) were first language English or Afrikaans speakers, while the health care workers (nurses and social workers) and cleaners were fluent in both the patients’ and clinician’s language. Our findings suggest that interpreters took on the following four roles during the interpreter-mediated psychiatric consultations: regulating turn-taking, cultural broker, gatekeeper and advocate. Our findings suggest that, despite interpreters and clinicians having the patient’s best interests at heart, it is the patient’s voice that becomes lost while the clinician and interpreter negotiate the roles played by each party.

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