scholarly journals Linking nutrient stoichiometry to Zika virus transmission in a mosquito

2019 ◽  
Author(s):  
Andrew S. Paige ◽  
Shawna K. Bellamy ◽  
Barry W. Alto ◽  
Catherine L. Dean ◽  
Donald A. Yee
Keyword(s):  
Zika Virus ◽  
Chemical Elements ◽  
Virus Transmission ◽  
Nutrient Stoichiometry ◽  
Allochthonous Input ◽  
Disseminated Infection ◽  
Definitive Evidence ◽  
Nitrogen Treatments ◽  
Percent Nitrogen ◽  
Host Parasite

ABSTRACTFood quality and quantity serve as the basis for cycling of key chemical elements in trophic interactions, yet the role of nutrient stoichiometry in shaping host-parasite interactions is under appreciated. Most of the emergent mosquito-borne viruses affecting human health are transmitted by mosquitoes that inhabit container systems during their immature stages, where allochthonous input of detritus serves as the basal nutrients. Quantity and type of detritus (animal and plant) were manipulated in microcosms containing newly hatched Aedes aegypti mosquito larvae. Adult mosquitoes derived from these microcosms were allowed to ingest Zika virus infected blood and then tested for disseminated infection, transmission, and total nutrients (percent carbon, percent nitrogen, ratio of carbon to nitrogen). Treatments lacking high quality animal (insect) detritus significantly delayed development. Survivorship to adulthood was closely associated with the amount of insect detritus present. Insect detritus was positively correlated with percent nitrogen, which affected Zika virus infection. Disseminated infection and transmission decreased with increasing insect detritus and percent nitrogen. We provide the first definitive evidence linking nutrient stoichiometry to arbovirus infection and transmission in a mosquito using a model system of invasive Ae. aegypti and emergent Zika virus.

scholarly journals Linking nutrient stoichiometry to Zika virus transmission in a mosquito

Oecologia ◽  
2019 ◽  
Vol 191 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Andrew S. Paige ◽  
Shawna K. Bellamy ◽  
Barry W. Alto ◽  
Catherine L. Dean ◽  
Donald A. Yee
Keyword(s):  
Zika Virus ◽  
Virus Transmission ◽  
Nutrient Stoichiometry

Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy — Brazil, 2015

2016 ◽  
Vol 65 (9) ◽  
Author(s):  
Wanderson Kleber de Oliveira ◽  
Juan Cortez-Escalante ◽  
Wanessa Tenório Gonçalves Holanda De Oliveira ◽  
Greice Madeleine Ikeda do Carmo ◽  
Cláudio Maierovitch Pessanha Henriques ◽  
...  
Keyword(s):  
Zika Virus ◽  
Virus Transmission ◽  
First Trimester ◽  
First Trimester Of Pregnancy

Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy — Brazil, 2015

2016 ◽  
Vol 65 (9) ◽  
pp. 242-247 ◽  
Author(s):  
Wanderson Kleber de Oliveira ◽  
Juan Cortez-Escalante ◽  
Wanessa Tenório Gonçalves Holanda De Oliveira ◽  
Greice Madeleine Ikeda do Carmo ◽  
Cláudio Maierovitch Pessanha Henriques ◽  
...  
Keyword(s):  
Zika Virus ◽  
Virus Transmission ◽  
First Trimester ◽  
First Trimester Of Pregnancy

scholarly journals Zika Virus Transmission-Region of the Americas, May 15, 2015-December 15, 2016

2017 ◽  
Vol 17 (6) ◽  
pp. 1681-1686 ◽  
Author(s):  
J. Ikejezie ◽  
C. N. Shapiro ◽  
J. Kim ◽  
M. Chiu ◽  
M. Almiron ◽  
...  
Keyword(s):  
Zika Virus ◽  
Virus Transmission ◽  
Transmission Region

scholarly journals Sequential Infection of Aedes aegypti Mosquitoes with Chikungunya Virus and Zika Virus Enhances Early Zika Virus Transmission

Insects ◽  
2018 ◽  
Vol 9 (4) ◽  
pp. 177 ◽  
Author(s):  
Tereza Magalhaes ◽  
Alexis Robison ◽  
Michael Young ◽  
William Black ◽  
Brian Foy ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Blood Meal ◽  
Zika Virus ◽  
Chikungunya Virus ◽  
Vector Competence ◽  
Virus Transmission ◽  
Mosquito Vector ◽  
Molecular Aspects ◽  
Virus Interactions ◽  
Sequential Infection

In urban settings, chikungunya, Zika, and dengue viruses are transmitted by Aedes aegypti mosquitoes. Since these viruses co-circulate in several regions, coinfection in humans and vectors may occur, and human coinfections have been frequently reported. Yet, little is known about the molecular aspects of virus interactions within hosts and how they contribute to arbovirus transmission dynamics. We have previously shown that Aedes aegypti exposed to chikungunya and Zika viruses in the same blood meal can become coinfected and transmit both viruses simultaneously. However, mosquitoes may also become coinfected by multiple, sequential feeds on single infected hosts. Therefore, we tested whether sequential infection with chikungunya and Zika viruses impacts mosquito vector competence. We exposed Ae. aegypti mosquitoes first to one virus and 7 days later to the other virus and compared infection, dissemination, and transmission rates between sequentially and single infected groups. We found that coinfection rates were high after sequential exposure and that mosquitoes were able to co-transmit both viruses. Surprisingly, chikungunya virus coinfection enhanced Zika virus transmission 7 days after the second blood meal. Our data demonstrate heterologous arbovirus synergism within mosquitoes, by unknown mechanisms, leading to enhancement of transmission under certain conditions.

scholarly journals Author response: Epidemiological and ecological determinants of Zika virus transmission in an urban setting

2017 ◽  
Author(s):  
José Lourenço ◽  
Maricelia Maia de Lima ◽  
Nuno Rodrigues Faria ◽  
Andrew Walker ◽  
Moritz UG Kraemer ◽  
...  
Keyword(s):  
Zika Virus ◽  
Virus Transmission ◽  
Urban Setting ◽  
Author Response

scholarly journals Vector distribution and transmission risk of the Zika virus in South and Central America

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7920
Author(s):  
Sarah Cunze ◽  
Judith Kochmann ◽  
Lisa K. Koch ◽  
Elisa Genthner ◽  
Sven Klimpel
Keyword(s):  
South America ◽  
Central America ◽  
Zika Virus ◽  
Habitat Suitability ◽  
Virus Transmission ◽  
Transmission Risk ◽  
Eastern Coast ◽  
Suitable Habitat ◽  
Virus Infections ◽  
Vector Species

Background Zika is of great medical relevance due to its rapid geographical spread in 2015 and 2016 in South America and its serious implications, for example, certain birth defects. Recent epidemics urgently require a better understanding of geographic patterns of the Zika virus transmission risk. This study aims to map the Zika virus transmission risk in South and Central America. We applied the maximum entropy approach, which is common for species distribution modelling, but is now also widely in use for estimating the geographical distribution of infectious diseases. Methods As predictor variables we used a set of variables considered to be potential drivers of both direct and indirect effects on the emergence of Zika. Specifically, we considered (a) the modelled habitat suitability for the two main vector species Aedes aegypti and Ae. albopictus as a proxy of vector species distributions; (b) temperature, as it has a great influence on virus transmission; (c) commonly called evidence consensus maps (ECM) of human Zika virus infections on a regional scale as a proxy for virus distribution; (d) ECM of human dengue virus infections and, (e) as possibly relevant socio-economic factors, population density and the gross domestic product. Results The highest values for the Zika transmission risk were modelled for the eastern coast of Brazil as well as in Central America, moderate values for the Amazon basin and low values for southern parts of South America. The following countries were modelled to be particularly affected: Brazil, Colombia, Cuba, Dominican Republic, El Salvador, Guatemala, Haiti, Honduras, Jamaica, Mexico, Puerto Rico and Venezuela. While modelled vector habitat suitability as predictor variable showed the highest contribution to the transmission risk model, temperature of the warmest quarter contributed only comparatively little. Areas with optimal temperature conditions for virus transmission overlapped only little with areas of suitable habitat conditions for the two main vector species. Instead, areas with the highest transmission risk were characterised as areas with temperatures below the optimum of the virus, but high habitat suitability modelled for the two main vector species. Conclusion Modelling approaches can help estimating the spatial and temporal dynamics of a disease. We focused on the key drivers relevant in the Zika transmission cycle (vector, pathogen, and hosts) and integrated each single component into the model. Despite the uncertainties generally associated with modelling, the approach applied in this study can be used as a tool and assist decision making and managing the spread of Zika.

Numerical study of Zika model as a mosquito-borne virus with non-singular fractional derivative

2021 ◽  
Author(s):  
Sachin Kumar ◽  
Dia Zeidan
Keyword(s):  
Fractional Derivative ◽  
Zika Virus ◽  
Numerical Study ◽  
Asymptomatic Carrier ◽  
Virus Transmission ◽  
Model Parameters ◽  
Human Society ◽  
Sexual Interaction ◽  
Virus Model ◽  
Global Threat

Zika virus infection, which is closely related to dengue, is becoming a global threat to human society. The transmission of the Zika virus from one human to another is spread by bites of Aedes mosquitoes. Recent studies also reveal the fact that the Zika virus can be transmitted by sexual interaction. In this paper, we use the fractional derivative with Mittag–Leffler non-singular kernel to study Zika virus transmission dynamics. This fractional is also known as the Atangana–Baleanu Caputo (ABC) derivative which is employed for the resulting system of ordinary differential equations. We investigate the proposed Zika virus model by using the Legendre spectral method. The model parameters are estimated and validated numerically by investigating the effect of fractional order exponent on various cases such as Susceptible human, infected human, asymptomatic carrier, exposed human, and recovered human. Numerical results obtained with the proposed method have been compared with exact solutions, showing in all parameters a very satisfactory agreement.

Zika virus hijacks extracellular vesicle tetraspanin pathways for cell-to-cell transmission

2021 ◽  
Author(s):  
Sara B. York ◽  
Li Sun ◽  
Allaura S. Cone ◽  
Leanne C. Duke ◽  
Mujeeb R. Cheerathodi ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Intercellular Communication ◽  
Zika Virus ◽  
Biological Fluids ◽  
Virus Transmission ◽  
First Trimester ◽  
Enhanced Production ◽  
Infected Cells ◽  
Encapsulated Structures

ABSTRACTExtracellular vesicles (EVs) are membrane-encapsulated structures released by cells which carry signaling factors, proteins and microRNAs that mediate intercellular communication. Accumulating evidence supports an important role of EVs in the progression of neurological conditions and both the spread and pathogenesis of infectious diseases. It has recently been demonstrated that EVs from Hepatitis C virus (HCV) infected individuals and cells contained replicative-competent viral RNA that was capable of infecting hepatocytes. Being a member of the same viral family, it is likely the Zika virus also hijacks EV pathways to package viral components and secrete vesicles that are infectious and potentially less immunogenic. As EVs have been shown to cross blood-brain and placental barriers, it is possible that Zika virus could usurp normal EV biology to gain access to the brain or developing fetus. Here, we demonstrate that Zika virus infected cells secrete distinct EV sub-populations with specific viral protein profiles and infectious genomes. Zika virus infection resulted in the enhanced production of EVs with varying sizes and density compared to those released from non-infected cells. We also show that the EV enriched tetraspanin CD63 regulates the release of EVs, and Zika viral genomes and capsids following infection. Overall, these findings provide evidence for an alternative means of Zika virus transmission and demonstrate the role of EV biogenesis and trafficking proteins in the modulation of Zika infection.ImportanceZika virus is a re-emerging infectious disease that spread rapidly across the Caribbean and South America. Infection of pregnant women during the first trimester has been linked to microcephaly, a neurological condition where babies are born with smaller heads due to abnormal brain development. Babies born with microcephaly can develop convulsions and suffer disabilities as they age. Despite the significance of Zika virus, little is known about how the virus infects the fetus or causes disease. Extracellular vesicles (EVs) are membrane-encapsulated structures released by cells that are present in all biological fluids. EVs carry signaling factors, proteins and microRNAs that mediate intercellular communication. EVs have been shown to be a means by which some viruses can alter cellular environments and cross previously unpassable cellular barriers. Thus gaining a greater understanding of how Zika affects EV cargo may aid in the development of better diagnostics, targeted therapeutics and prophylactic treatments.

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