scholarly journals Transcriptomic Analysis of the Neurogenesis Signature suggests Continued but Minimal Neurogenesis in the Adult Human Hippocampus

2019 ◽  
Author(s):  
Ashutosh Kumar ◽  
Vikas Pareek ◽  
Muneeb A. Faiq ◽  
Pavan Kumar ◽  
Chiman Kumari ◽  
...  
Keyword(s):  
Early Childhood ◽  
Age Groups ◽  
Transcriptomic Analysis ◽  
Expression Data ◽  
Adult Age ◽  
Sharp Fall ◽  
Adult Human ◽  
Apoptotic Markers ◽  
Human Hippocampus ◽  
Late Maturation

AbstractPurposeSince immunohistological investigations have given rise to divergent perspectives about continued hippocampal neurogenesis in adult humans, a comprehensive transcriptomic analysis of the neurogenesis signature markers supplemented with insights from gliogenesis and apoptotic markers (in context to the developmental stages across age) may discern important aspects and may well be the appropriate methodology for resolving this conflict.Materials and MethodsRNA expression data for the salient neurogenesis, gliogenesis, and apoptotic marker genes in post-mortem human hippocampal tissue of the Prenatal (n=15), Infant/Early childhood (n= 5), Adolescence (n=4), and Adulthood (n=6) ages were downloaded from Allen Brain Atlas database (http://www.brainspan.org/rnaseq). Gene expression data was categorized, median values were computed, and age group specific differential expression was statistically analyzed (the confidence level of 95%, p value ≤ 0.05 is used).ResultsA sharp fall in prenatal to infant/early childhood expression was observed for all studied neurogenesis markers, except that for the post-mitotic late maturation (CALB1, CALB2, MAP2, NEUN, STMN2) which showed no significant differences in expression profiles. A continued post childhood decrease across advancing age was observed in the neural stem cells and progenitor markers with insignificant differences across close age groups. Uniquely, the postnatal sharp fall of KI67 and TBR2 continued across advancing age groups, reached near baseline until adolescent age. The immature granule cell, post mitotic early maturation, and late maturation markers showed a maintained or slightly increased (albeit insignificant) post childhood expression. The gliogenesis markers mostly showed a significant downregulation between prenatal and infant /early childhood age groups; this decline was persistent thereafter with insignificant differences between close age groups. A continued postnatal decrease occurred in apoptotic markers with observable, but insignificant, differences between adolescent and adult age.ConclusionsOur findings indicate a possibility of continued but minimal neurogenesis in the adult human hippocampus. A significant part of the newborn cells in the neurogenic niche may be glial cells.(Findings of this study were first presented at the Annual Meeting of Society for Neuroscience (SFN), 3rd-7th November, 2018, San Diego, USA.https://abstractsonline.com/pp8/#!/4649/presentation/37213)Graphical AbstractHighlightsA varying but continued fall in expression was observed for all studied neurogenesis markers across advancing age groups, except that for the immature granule cells, early and post-mitotic late neuronal maturation markers.A continued postnatal sharp fall of progenitor markers KI67 and TBR2 reached near baseline until adolescent age.Gliogenesis markers showed continued but insignificant fall in expression post infant/early childhood.Apoptotic markers showed continued post infant/early childhood downfall but changes were negligible between adolescent and adult age.

Assessment of ST2 for Risk of Death Following Graft-versus-Host Disease in the Pediatric and Adult Age Groups

2019 ◽  
Author(s):  
Courtney Rowan ◽  
Francis Pike ◽  
Kenneth R. Cooke ◽  
Robert Krance ◽  
Paul A. Carpenter ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Age Groups ◽  
Host Disease ◽  
Adult Age ◽  
Graft Versus Host ◽  
Risk Of Death

scholarly journals How does general practitioner discontinuity affect healthcare utilisation? An observational cohort study of 2.4 million Norwegians 2007–2017

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e042391
Author(s):  
Lena Janita Skarshaug ◽  
Silje Lill Kaspersen ◽  
Johan Håkon Bjørngaard ◽  
Kristine Pape
Keyword(s):  
Cohort Study ◽  
General Practitioner ◽  
Service Use ◽  
Hospital Admissions ◽  
Age Groups ◽  
Healthcare Utilisation ◽  
Acute Hospital ◽  
Secondary Outcome ◽  
Out Of Hours ◽  
Adult Age

ObjectivesPatients may benefit from continuity of care by a personal physician general practitioner (GP), but there are few studies on consequences of a break in continuity of GP. Investigate how a sudden discontinuity of GP care affects their list patients’ regular GP consultations, out-of-hours consultations and acute hospital admissions, including admissions for ambulatory care sensitive conditions (ACSC).DesignCohort study linking person-level national register data on use of health services and GP affiliation with data on GP activity and GP characteristics.SettingPrimary care.Participants2 409 409 Norwegians assigned to the patient lists of 2560 regular GPs who, after 12 months of stable practice, had a sudden discontinuity of practice lasting two or more months between 2007 and 2017.Primary and secondary outcome measuresMonthly GP consultations, out-of-hours consultations, acute hospital admissions and ACSC admissions in periods during and 12 months after the discontinuity, compared with the 12-month period before the discontinuity using logistic regression models.ResultsAll patient age groups had a 3%–5% decreased odds of monthly regular GP consultations during the discontinuity. Odds of monthly out-of-hours consultations increased 2%–6% during the discontinuity for all adult age groups. A 7%–9% increase in odds of ACSC admissions during the period 1–6 months after discontinuity was indicated in patients over the age of 65, but in general little or no change in acute hospital admissions was observed during or after the period of discontinuity.ConclusionsModest changes in health service use were observed during and after a sudden discontinuity in practice among patients with a previously stable regular GP. Older patients seem sensitive to increased acute hospital admissions in the absence of their personal GP.

scholarly journals Physical Activity of Serbian Children in Daycare

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 161
Author(s):  
Milenko Janković ◽  
Maja Batez ◽  
Dušan Stupar ◽  
Jelena Obradović ◽  
Nebojša Trajković
Keyword(s):  
Physical Activity ◽  
Early Childhood ◽  
Urban Environment ◽  
Educational Institution ◽  
Univariate Analysis ◽  
Age Groups ◽  
Preschool Age ◽  
Variance Test ◽  
Significant Difference ◽  
Novi Sad

Background: Monitoring of physical activity within the educational institution is of great importance, primarily because of the orientation and content implemented in the daycare. This research aimed to examine the number of steps children took during their stay in daycare with regards to age, gender and the frequency of going out. Methods: The research was conducted in four daycares in the urban environment of Novi Sad (Republic of Serbia), where 231 children, aged 5 to 7, were monitored (129 boys and 102 girls). Data on the number of steps were obtained using the pedometers. Results: The result of the univariate analysis of the variance test confirmed a statistically significant difference in the number of steps in relation to the age of children (p = 0.04). Boys were more active than girls in both age groups (p = 0.001). Children who were going to the daycare yard three to five times a week took drastically more steps than children who went up to twice a week (p = 0.001). Conclusion: The results of the current study show that age, gender, and time spent outdoors are significant determinants of physical activity in preschool age. Therefore, interventions regarding physical activity should be made during early childhood in order to promote health and prevent disease.

ATTITUDE TOWARDS MYTHS AND MISCONCEPTIONS AMONG ADOLESCENT GIRLS DURING THE MENSTRUATION

2021 ◽  
pp. 42-43
Author(s):  
J. C. Kavitha Latha ◽  
R. Varalakshmi
Keyword(s):  
Adolescent Girls ◽  
Transition Period ◽  
Age Groups ◽  
Adult Life ◽  
Negative Attitude ◽  
Adult Age ◽  
Hygiene Practices ◽  
Minimal Sample ◽  
High Attitude ◽  
The Right

Adolescents are dened as the young people between the age groups of 10 and 19 years as per the WHO records. Adolescence is a transition period from childhood to adult life as it is regarded as the intermediate period between the childhood age and the adult age. Menstruation occurs every month periodically except during pregnancy. The maintenance of menstrual hygienic methods is a very challenging task to the adolescent girls. Social prohibitions and traditional beliefs blocked the access to get the right kind of information to adolescent girls that led to poor hygiene practices. Menstruation has often been dealt with secrecy in many cultures. Aim: Attitude towards myths and misconceptions among adolescent girls during the menstruation. To assess the attitude regarding myths Objective: and misconceptions among adolescent girls during the menstruation. To examine the level of attitude of adolescent girls towards Myths and Misconceptions Tool: The Tool used for the present study was self structured questionnaire which was developed by the researcher. Results: Many of number of adolescent girls is having low attitude i.e., having many myths and misconceptions towards menstruation and very few sample is having high attitude which is indicating that minimal sample is not having negative attitude towards the myths and misconceptions. Sample: Sample of the present study consists of 300 adolescent girls from government vocational colleges in Chittoor District of Andhra Pradesh State. There are signicant differences between age, religion, educational quali Conclusion: cations of mother's, type of family and mode of communication among adolescent girls with regard to their attitude towards myths and misconceptions during the menstruation. There is low level of attitude towards the myths and misconceptions among adolescent girls during the menstruation

scholarly journals Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups

Nutrients ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 1325 ◽  
Author(s):  
Jeffrey Blumberg ◽  
Balz Frei ◽  
Victor Fulgoni ◽  
Connie Weaver ◽  
Steven Zeisel
Keyword(s):  
Dietary Supplements ◽  
Age Groups ◽  
Nutritional Adequacy ◽  
Adult Age

Age Related Prevalence of Pre-Eruptive Intracoronal Radiolucent Defects in the Permanent Dentition

2016 ◽  
Vol 40 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Marina Umansky ◽  
Nili Tickotsky ◽  
Silvina Friedlander-Barenboim ◽  
Sarit Faibis ◽  
Moti Moskovitz
Keyword(s):  
Retrospective Study ◽  
Age Groups ◽  
Third Molar ◽  
Young Group ◽  
Young Age ◽  
Permanent Teeth ◽  
Significance Level ◽  
Adult Age ◽  
Age Related ◽  
Unerupted Teeth

Objective: The present study aimed to determine if the prevalence of pre-eruptive intracoronal radiolucent defects is higher for young age groups, in which there are more unerupted teeth. Study design: A retrospective study of panoramic and bitewing radiographs was conducted. An inclusion criterion was the presence of un-erupted permanent teeth with a formed and clearly visible crown. Age groups were: young (6–8 years), intermediate (9–12 years) and adults (13–53 years). Significance level was set at p≤0.05. Results: Thirteen (3.9%) pre-eruptive lesions were detected in 335 records. No lesions were found in the young group (7.4%), in the intermediate and adult age groups six and seven lesions were found, respectively. In most cases the pre-eruptive lesion was found in a third molar. Conclusion: The prevalence of pre-eruptive intracoronal lesions was not higher for young age groups. The prevalence of pre-eruptive intra coronal radiolucent lesions is 3.9%, irrespective of age.

Differential fertility among immigrants to England and Wales and some implications for population projections

1969 ◽  
Vol 1 (S1) ◽  
pp. 119-127 ◽  
Author(s):  
Jean Thompson
Keyword(s):  
Age Structure ◽  
Age Groups ◽  
Population Projections ◽  
Fertility Rates ◽  
Female Population ◽  
Differential Fertility ◽  
England And Wales ◽  
Adult Age ◽  
Completed Family Size ◽  
Socio Economic Factors

SummaryThe age structure of the immigrant female population as shown by the 1961 Census was heavily biased towards the young adult age groups, where fertility rates are highest. The birth rate for such a population could be expected considerably to exceed the average for this country as a whole, due to differences in age structure alone. The Census also showed marked differences betwen the fertility rates of different groups of immigrants but suggested that for the most important groups —from the Irish Republic, the Indian sub-continent and the Caribbean—they then amounted to a completed family size of roughly ½ child above the England and Wales average. There were also marked differences in 1961 between the socio-economic structure of immigrant groups; such evidence as there is points to socio-economic factors as playing an important part in explaining the fertility of immigrants, and its possible change over time.

scholarly journals Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus

2021 ◽  
Vol 41 (12) ◽  
pp. 2554-2565
Author(s):  
Shawn F. Sorrells ◽  
Mercedes F. Paredes ◽  
Zhuangzhi Zhang ◽  
Gugene Kang ◽  
Oier Pastor-Alonso ◽  
...  
Keyword(s):  
Adult Human ◽  
Human Hippocampus ◽  
Adults And Children ◽  
Positive Controls

scholarly journals Request Strategies in the American TV Series Full House

Lexicon ◽  
2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Yemima Febriani ◽  
Sharifah Hanidar
Keyword(s):  
Social Distance ◽  
Family Members ◽  
Age Groups ◽  
The Other ◽  
Relative Power ◽  
Adult Age ◽  
Other Hand ◽  
Younger Age ◽  
The Social ◽  
Request Strategies

This research aims to analyze the request strategies used in an American TV Series entitled Full House season 7 episodes 1-12. The main characters are family members from three different age groups (adult, teenager, and children). This research attempts to see if there is any difference on the choice of request strategies used by the three age groups. Blum-Kulka and Olshtain’s (1984) theory on request directness level is used to classify the requests. Relative power and social distance are also studied to see how they influence the characters in making their requests. The results show that mood derivable is the most frequent strategy used by all age groups. Specifically, direct request is highly used by the adult age groups. On the other hand, indirect request is mostly used by the younger age groups. The results also show that all age groups tend to use direct strategy when the social distance is negative. However, when the social distance is positive, the choice of strategy depends on the authority of the speaker.

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