scholarly journals High circulating elafin levels are associated with Crohn’s disease-associated intestinal strictures

2019 ◽  
Author(s):  
Jiani Wang ◽  
Christina Ortiz ◽  
Lindsey Fontenot ◽  
Ying Xie ◽  
Wendy Ho ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Protein Expression ◽  
Antimicrobial Peptide ◽  
Disease Activity ◽  
High Serum ◽  
Clinical Disease ◽  
Clinical Disease Activity ◽  
Mayo Score ◽  
Intestinal Stricture ◽  
Mesenteric Fat

AbstractObjectiveNearly 33% of Crohn’s disease (CD) patients develop intestinal strictures. Antimicrobial peptide or protein expression is associated with disease activity in inflammatory bowel disease (IBD) patients. Circulating blood cells and intestine of IBD patients have abnormal expression of elafin, a human elastase-specific protease inhibitor and antimicrobial peptide. However, the association between elafin and CD-associated intestinal stricture is unknown. We hypothesize the elafin expression in stricturing CD patients is abnormal. We determined the expression of elafin in blood, intestine, and mesenteric fat in IBD patients.MethodsHuman colonic and mesenteric fat tissues and serum samples were collected from the Cedars-Sinai Medical Center and UCLA, respectively.ResultsHigh serum elafin levels were associated with a significantly elevated risk of intestinal stricture in CD patients. Machine learning algorithm using serum elafin levels and clinical data identified stricturing CD patients with high accuracy. Serum elafin levels had weak positive correlation with clinical disease activity (Partial Mayo Score and Harvey Bradshaw Index) in IBD patients. Ulcerative colitis (UC) patients had high serum elafin levels, but the increase was not associated with endoscopic Mayo score. Colonic elafin mRNA and protein expression were not associated with clinical disease activity in IBD patients, while stricturing CD patients had low colonic elafin expression. Mesenteric fat in stricturing CD patients had significantly increased elafin mRNA expression, which may contribute to high circulating elafin level.ConclusionHigh serum elafin levels and adipose elafin expression are associated with intestinal strictures, which may help identify intestinal strictures in CD patients.

scholarly journals Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn’s Disease

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Elizabeth A. Scoville ◽  
Margaret M. Allaman ◽  
Dawn W. Adams ◽  
Amy K. Motley ◽  
Shannon C. Peyton ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Polyunsaturated Fatty Acids ◽  
Disease Activity ◽  
Clinical Disease ◽  
Clinical Disease Activity ◽  
Serum Cytokines

Mucosa-attached bacterial community in Crohn's disease coheres with the clinical disease activity index

2016 ◽  
Vol 8 (5) ◽  
pp. 614-621 ◽  
Author(s):  
Holger Schäffler ◽  
Daniel P. R. Herlemann ◽  
Christian Alberts ◽  
Annika Kaschitzki ◽  
Peggy Bodammer ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bacterial Community ◽  
Disease Activity ◽  
Activity Index ◽  
Disease Activity Index ◽  
Clinical Disease Activity Index ◽  
Clinical Disease ◽  
Clinical Disease Activity

Assessment of capsule endoscopy scoring index, clinical disease activity, and C-reactive protein in small bowel Crohn's disease

2013 ◽  
Vol 28 (5) ◽  
pp. 829-833 ◽  
Author(s):  
Li Yang ◽  
Zhi-Zheng Ge ◽  
Yun-Jie Gao ◽  
Xiao-Bo Li ◽  
Jun Dai ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Capsule Endoscopy ◽  
Clinical Disease ◽  
C Reactive Protein ◽  
Clinical Disease Activity ◽  
Reactive Protein ◽  
Scoring Index

scholarly journals Optimizing Patient Management in Crohn’s Disease in a Tertiary Referral Center: the Impact of Fast-Track MRI on Patient Management and Outcomes

2018 ◽  
Vol 27 (4) ◽  
pp. 391-397 ◽  
Author(s):  
Akos Ilias ◽  
Barbara D Lovasz ◽  
Lorant Gonczi ◽  
Zsuzsanna Kurti ◽  
Zsuzsanna Vegh ◽  
...  
Keyword(s):  
Decision Making ◽  
Crohn’S Disease ◽  
Disease Activity ◽  
Patient Management ◽  
Fast Track ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Clinical Disease ◽  
Clinical Disease Activity ◽  
The Impact

Background & Aims: Rapid optimization of treatment algorithms and disease outcomes requires an objective measurement of disease activity in patients with Crohn’s disease (CD). Our aim was to evaluate the impact of rapid-access to magnetic resonance imaging (MRI) on treatment optimization, clinical decision-making and outcomes for CD patients in a specialized tertiary care for inflammatory bowel disease (IBD) patients.Methods: A cohort of 75 referral CD patients (median age: 34, IQR: 25-43 years) who had underwent 90 fasttrack MR enterography (MRE) scans between January 2014 and June 2016 were retrospectively enrolled. The MRI results were compared to clinical activity scores and biomarkers (C-reactive protein). The immediate impact of fast-track MRI on clinical decision-making, including changes in medical therapy, the need of hospitalization and surgery were evaluated.Results: The location of CD was ileo-colonic in 61% of the patients with perianal fistulas in 56% and previous surgeries in 55%. The indication for fast-track MRI scans was active disease (clinical or biomarker activity) in 55.6%. The radiological activity (including mild radiological signs to severe lesions) was detected in 94% of cases. Significant/severe MRI activity was depicted in 68% of these patients. Correlation between MRI radiological activity and clinical disease activity or colonoscopy was moderate (kappa: 0.609 and 0.652). A change in therapeutic strategy was made in 94.1% of cases with severe MRI radiological activity vs. 50% of patients without severe MRI radiological activity (p=0.001). Significant/severe MRI activity was followed by higher surgery rates among patients with clinical disease activity (50% vs. 12.5%; p=0.013). MRI performed on patients with clinical and biomarker remission identified disease activity in a significantly smaller proportion.Conclusions: Fast-track MRI had a great impact on patient management in CD patients with clinical or biomarker activity, leading to better patient stratification and faster optimization of the therapy (medical or surgical), while MRI revealed previously undiagnosed disease activity only in a small proportion of patients in clinical remission.

scholarly journals Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn's Disease

2017 ◽  
Vol 152 (5) ◽  
pp. S761-S762
Author(s):  
Elizabeth A. Scoville ◽  
Dawn W. Adams ◽  
Margaret M. Allaman ◽  
Amy Motley ◽  
Shannon C. Peyton ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Polyunsaturated Fatty Acids ◽  
Disease Activity ◽  
Clinical Disease ◽  
Clinical Disease Activity ◽  
Serum Cytokines

Clinical disease activity, C-reactive protein normalisation and mucosal healing in Crohn's disease in the SONIC trial

Gut ◽  
2013 ◽  
Vol 63 (1) ◽  
pp. 88-95 ◽  
Author(s):  
Laurent Peyrin-Biroulet ◽  
Walter Reinisch ◽  
Jean-Frederic Colombel ◽  
Gerassimos J Mantzaris ◽  
Asher Kornbluth ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Mucosal Healing ◽  
Clinical Disease ◽  
C Reactive Protein ◽  
Clinical Disease Activity ◽  
Reactive Protein

Tu1972 The Use of Fecal Calprotectin to Understand the Expanded Utility of IBD Clinical Disease Activity and Quality of Life Assessments in Crohn's Disease and Ulcerative Colitis

2016 ◽  
Vol 150 (4) ◽  
pp. S994
Author(s):  
David Hudesman ◽  
Arun Swaminath ◽  
Dana J. Lukin ◽  
Mitchell Bernstein ◽  
Lisa Malter ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Fecal Calprotectin ◽  
Clinical Disease ◽  
Clinical Disease Activity

CT of Prominent Pericolic or Perienteric Vasculature in Patients with Crohn's Disease: Correlation with Clinical Disease Activity and Findings on Barium Studies

2002 ◽  
Vol 179 (4) ◽  
pp. 1029-1036 ◽  
Author(s):  
Seung Soo Lee ◽  
Hyun Kwon Ha ◽  
Suk-Kyun Yang ◽  
Ah Young Kim ◽  
Tae Kyoung Kim ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Clinical Disease ◽  
Clinical Disease Activity ◽  
Barium Studies
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