Prognostic value of Red Blood Cell Distribution Width in Acute Kidney Injury Patients: A Systematic Review and Meta-analysis

AbstractBackgroundThe conflicting result with regard to Red Cell Distribution Width (RDW) with Acute Kidney Injury (AKI) has been reported. This systematic review and meta-analysis were aimed to investigate RDW and prognostic value in AKI patients.Methods/Main ResultsThis meta-analysis included 1251 cases and 1663 controls with a total of 7 enrolled published papers. The results of RDW levels were significantly associated with patients of AKI (WMD=1.127, 95% CI=0.426-1.827; P=0.002), with statistically significant heterogeneity (I2 =95.80%, Pheterogeneity =0.000, random-effects model).ConclusionsIn conclusion, the results of this present meta-analysis suggest that the RDW value is a positive prognostic indicator in patients with AKI. However, these results were obtained on the basis of RCS or small sample sizes studies. Further functional studies with additional data would be needed to validate our findings.

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Prognostic value of cell cycle arrest biomarkers in patients at high risk for acute kidney injury: A systematic review and meta-analysis

Nephrology ◽

10.1111/nep.13095 ◽

2017 ◽

Vol 22 (11) ◽

pp. 831-837 ◽

Cited By ~ 11

Author(s):

Hui-Miao Jia ◽

Li-Feng Huang ◽

Yue Zheng ◽

Wen-Xiong Li

Keyword(s):

Systematic Review ◽

Cell Cycle ◽

Acute Kidney Injury ◽

High Risk ◽

Cell Cycle Arrest ◽

Prognostic Value ◽

Meta Analysis ◽

Kidney Injury ◽

Cycle Arrest

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Prognostic Value of Red Blood Cell Distribution Width for Patients with Heart Failure: A Systematic Review and Meta-Analysis of Cohort Studies

PLoS ONE ◽

10.1371/journal.pone.0104861 ◽

2014 ◽

Vol 9 (8) ◽

pp. e104861 ◽

Cited By ~ 44

Author(s):

Yuan-Lan Huang ◽

Zhi-De Hu ◽

Shi-Jian Liu ◽

Yi Sun ◽

Qin Qin ◽

...

Keyword(s):

Heart Failure ◽

Systematic Review ◽

Blood Cell ◽

Cohort Studies ◽

Prognostic Value ◽

Meta Analysis ◽

Cell Distribution ◽

Distribution Width ◽

Patients With Heart Failure ◽

Red Blood Cell Distribution

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A SYSTEMATIC REVIEW AND META-ANALYSIS ON THE PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH ON DEVELOPMENT OF CONTRAST INDUCED NEPHROPATHY IN CORONARY ARTERY DISEASE PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(20)31996-3 ◽

2020 ◽

Vol 75 (11) ◽

pp. 1369

Author(s):

Muhammad J. Ahsan ◽

Saad Ullah Malik ◽

Omar Kousa ◽

Hafiz Muhammad Fazeel ◽

Nisma Javed ◽

...

Keyword(s):

Systematic Review ◽

Prognostic Value ◽

Meta Analysis ◽

Coronary Intervention ◽

Red Cell ◽

Cell Distribution ◽

Contrast Induced Nephropathy ◽

Distribution Width ◽

Percutaneous Coronary ◽

Artery Disease

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Prognostic Value of Red blood cell distribution width in Patients with Acute Pulmonary Embolism: A protocol for systematic review and meta-analysis

10.37766/inplasy2021.3.0036 ◽

2021 ◽

Author(s):

Liao Ye

Keyword(s):

Systematic Review ◽

Pulmonary Embolism ◽

Blood Cell ◽

Red Blood Cell ◽

Prognostic Value ◽

Acute Pulmonary Embolism ◽

Meta Analysis ◽

Cell Distribution ◽

Distribution Width ◽

Red Blood Cell Distribution

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COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-Analysis

Pathogens ◽

10.3390/pathogens9121052 ◽

2020 ◽

Vol 9 (12) ◽

pp. 1052

Author(s):

Fabrizio Fabrizi ◽

Carlo M. Alfieri ◽

Roberta Cerutti ◽

Giovanna Lunghi ◽

Piergiorgio Messa

Keyword(s):

Systematic Review ◽

Acute Kidney Injury ◽

Clinical Studies ◽

Meta Analysis ◽

Kidney Injury ◽

Preliminary Evidence ◽

High Morbidity ◽

Significant Heterogeneity ◽

Outcomes Study ◽

Poor Outcomes

Background: coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome—coronavirus-2 (SARS-CoV-2)—is an ongoing pandemic with high morbidity and mortality rates. Preliminary evidence suggests that acute kidney injury (AKI) is uncommon in patients with COVID-19 and associated with poor outcomes. Study aims and design: we performed a systematic review of the literature with a meta-analysis of clinical studies to evaluate the frequency of AKI and dialysis requirement in patients who underwent hospitalization due to COVID-19. The incidence of AKI according to the death risk was calculated in these patients. The random-effects model of DerSimonian and Laird was adopted, with heterogeneity and stratified analyses. Results: thirty-nine clinical studies (n = 25,566 unique patients) were retrieved. The pooled incidence of AKI was 0.154 (95% CI, 0.107; 0.201; p < 0.0001) across the studies. Significant heterogeneity was found (p = 0.0001). The overall frequency of COVID-19-positive patients who underwent renal replacement therapy (RRT) was 0.043 (95% CI, 0.031; 0.055; p < 0.0001); no publication bias was found (Egger’s test, p = 0.11). The pooled estimate of AKI incidence in patients with severe COVID-19 was 0.53 (95% CI, 0.427; 0.633) and heterogeneity occurred (Q = 621.08, I2 = 97.26, p = 0.0001). According to our meta-regression, age (p < 0.007) and arterial hypertension (p < 0.001) were associated with AKI occurrence in hospitalized COVID-19 positive patients. The odds ratio (OR) for the incidence of AKI in deceased COVID-19 positive patients was greater than among survivors, 15.4 (95% CI, 20.99; 11.4; p < 0.001). Conclusions: AKI is a common complication in hospitalized COVID-19 positive patients. Additional studies are under way to assess the risk of AKI in COVID-19 patients and to deepen the mechanisms of kidney injury.

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