scholarly journals The OpenPicoAmp-100k : an open-source high performance amplifier for single channel recording in planar lipid bilayers

2019 ◽  
Author(s):  
V Shlyonsky ◽  
D Gall
Keyword(s):  
Ion Channel ◽  
Open Source ◽  
Lipid Bilayers ◽  
High Speed ◽  
High Performance ◽  
Printed Circuit Board ◽  
Single Channel ◽  
Circuit Board ◽  
Channel Current ◽  
Current Events

AbstractWe propose an upgraded version of our previously designed open-source lipid bilayer amplifier. This improved amplifier is now suitable both for the use in introductory courses in biophysics and neurosciences at the undergraduate level and for scientific research. Similar to its predecessor, the OpenPicoAmp-100k is designed using the common lithographic printed circuit board fabrication process and off-the-shelf electronic components. It consists of the high-speed headstage, followed by voltage-gain amplifier with built-in 6-order Bessel filter. The amplifier has a bandwidth of 100 kHz in the presence of 100 pF input membrane capacitance and is capable of measuring ion channel current with amplitudes from sub-pA and up to ±4 nA. At the full bandwidth and with a 1 GΩ transimpedance gain, the amplifier shows 12 pArms noise with an open input and 112 pArms noise in the presence of 100 pF input capacitance, while at the 5 kHz bandwidth (typical in single-channel experiments) noise amounts to 0.45 pArms and 2.11 pArms, respectively. Using an optocoupler circuit producing TTL-controlled current impulses and using 50% threshold analysis we show that at full bandwidth the amplifier has deadtimes of 3.5 µs and 5 µs at signal-to-noise ratios(SNR) of 9 and 1.7, respectively. Near 100% of true current impulses longer than 5 µs and 6.6 µs are detected at these two respective SNRs, while false event detection rate remains acceptably low. The wide bandwidth of the amplifier was confirmed in bilayer experiments with alamethicin, for which open ion channel current events shorter that 10 µs could be resolved.

Critical Aspects of High-Performance Microprocessor Packaging

MRS Bulletin ◽  
2003 ◽  
Vol 28 (1) ◽  
pp. 21-34 ◽  
Author(s):  
Vasudeva P. Atluri ◽  
Ravi V. Mahajan ◽  
Priyavadan R. Patel ◽  
Debendra Mallik ◽  
John Tang ◽  
...  
Keyword(s):  
High Speed ◽  
High Performance ◽  
Heat Dissipation ◽  
Printed Circuit Board ◽  
Power Input ◽  
Power Delivery ◽  
Circuit Board ◽  
Perspective View ◽  
Broad Perspective ◽  
Future Evolution

AbstractHistorically, the primary function of microprocessor packaging has been to facilitate electrical connectivity of the complex and intricate silicon microprocessor chips to the printed circuit board while providing protection to the chips from the external environment. However, as microprocessor performance continues to follow Moore's law, the package has evolved from a simple protective enclosure to a key enabler of performance. The art and science of semiconductor packaging has advanced radically over the past few decades as faster and more powerful microprocessors with tens of millions of transistors continue to be available, which require more signal and power input/output connections as well as greater power-dissipation capabilities. Key drivers for the development of packaging technologies include power delivery, thermal management, and interconnect scaling, in which the space transformation from fine-featured silicon interconnects to the relatively coarse features seen on motherboards has to be enabled by the package. These drivers, under constant market-driven cost pressure, have led to increased demands on new materials and new package architectures to enable silicon performance. Significant advances have already been made in the areas of heat dissipation, power delivery, high-speed signaling, and high-density interconnects. It is expected that the future evolution of microprocessors will be increasingly challenging in these areas. This article focuses on providing a broad perspective view of the evolution of microprocessor packaging and discusses future challenges.

scholarly journals A Self-Powered Nanogenerator for the Electrical Protection of Integrated Circuits from Trace Amounts of Liquid

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Zhuang Hui ◽  
Ming Xiao ◽  
Daozhi Shen ◽  
Jiayun Feng ◽  
Peng Peng ◽  
...  
Keyword(s):  
Integrated Circuits ◽  
High Performance ◽  
Printed Circuit Board ◽  
Short Circuit ◽  
High Sensitivity ◽  
Short Circuit Current ◽  
Fast Response ◽  
Open Circuit ◽  
Circuit Board ◽  
Self Powered

Abstract With the increase in the use of electronic devices in many different environments, a need has arisen for an easily implemented method for the rapid, sensitive detection of liquids in the vicinity of electronic components. In this work, a high-performance power generator that combines carbon nanoparticles and TiO2 nanowires has been fabricated by sequential electrophoretic deposition (EPD). The open-circuit voltage and short-circuit current of a single generator are found to exceed 0.7 V and 100 μA when 6 μL of water was applied. The generator is also found to have a stable and reproducible response to other liquids. An output voltage of 0.3 V was obtained after 244, 876, 931, and 184 μs, on exposure of the generator to 6 μL of water, ethanol, acetone, and methanol, respectively. The fast response time and high sensitivity to liquids show that the device has great potential for the detection of small quantities of liquid. In addition, the simple easily implemented sequential EPD method ensures the high mechanical strength of the device. This compact, reliable device provides a new method for the sensitive, rapid detection of extraneous liquids before they can impact the performance of electronic circuits, particularly those on printed circuit board.

Design of Equivalent Sampling Based on Printed Circuit Board Suited for Power Communication System

2013 ◽  
Vol 333-335 ◽  
pp. 465-471
Author(s):  
Chuan Liu ◽  
Zhi Chao Huang ◽  
Peng Wu ◽  
Lei Chen ◽  
Wei Wang
Keyword(s):  
Time Delay ◽  
Communication System ◽  
High Speed ◽  
Printed Circuit Board ◽  
Circuit Board ◽  
Transmission Time ◽  
Clock Signal ◽  
Signal Delay ◽  
Printed Circuit ◽  
Sequential Logic

Many applications in Power communication system have a demand of adjustable transmission time delay of high-speed signal. In sequential logic circuit, the control of transmission time delay of high-speed signal can effectively improve the accuracy of clock sampling, as a result, satisfy the constraints between clock signal and periodic data. A method of equivalent sampling based on printed circuit board (PCB) is provided in the article, it realizes equivalent sampling of the data by fixing a group of clock signal delay, thus, increase the accuracy of sampling.

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