Is DNA repair controlled by a biological logic circuit?

The possible utilization of biological logic circuit(s) in the integration and regulation of DNA repair is discussed. The author believes this mode of regulation likely applies to many other areas of cell biology; however, there are currently more experimental data to support its involvement in the control of DNA repair. Sequential logic processes always require a clock to orchestrate the orderly processing of events. In the proposed hypothesis, the pulses in the expression of p53 serve this function. Given the many advantages of logic type control, one would expect that in the course of ~ 3 billion years of evolution, where single cell life forms were likely the only forms of life, a biological logic type control system would have evolved to control at least some biological processes. Several other required components in addition to the ‘clock’ have been identified, such as; a method to temporarily inactivate repair processes when they are not required (e.g. the reversible inactivation of MGMT, a suicide repair protein, by phosphorylation); this prevents complex DNA repair systems with potentially overlapping repair functions from interfering with each other.

A mechanical metamaterial with reprogrammable logical functions

Embedding mechanical logic into soft robotics, microelectromechanical systems (MEMS), and robotic materials can greatly improve their functional capacity. However, such logical functions are usually pre-programmed and can hardly be altered during in-life service, limiting their applications under varying working conditions. Here, we propose a reprogrammable mechanological metamaterial (ReMM). Logical computing is achieved by imposing sequential excitations. The system can be initialized and reprogrammed via selectively imposing and releasing the excitations. Realization of universal combinatorial logic and sequential logic (memory) is demonstrated experimentally and numerically. The fabrication scalability of the system is also discussed. We expect the ReMM can serve as a platform for constructing reusable and multifunctional mechanical systems with strong computation and information processing capability.

Korean causal markers ‑ese and ‑nikka in clause-initial and final positions in relation to the sequence of Mandarin Chinese yinwei

Korean causal markers ‑ese, ‑nikka and Mandarin Chinese yinwei are used most widely in their respective languages to denote causality. Due to the syntactic structure of the adjunct-preceding-main order in both languages, ‑ese and ‑nikka are considered to be clause-initial connectives. However, in both languages, because-clauses also occur frequently in final position. By examining the behavioral patterns of ‑ese and ‑nikka in clause-initial and -final positions in relation to the sequence of yinwei through the original Korean texts translated to Mandarin Chinese and the Korean texts translated from the original Mandarin Chinese texts, this paper aims to show: (1) ese-tokens correspond more to the preposed yinwei and other Mandarin Chinese result causal markers that strengthen the “cause-consequence” construction, as ‑ese mainly expresses forward logical reasoning, whereas nikka-tokens correspond more to the postposed yinwei, as ‑nikka expresses epistemic inference and elaboration; (2) these logical relations are more explicitly expressed by ‑ese and ‑nikka, whereas Mandarin Chinese relies more on zero-marking when expressing a strong sense of sequential logic or an utterance of elaboration.

Morphological Sensitivity and Falling Behavior of Paper V-Shapes

Behavioral diversity seen in biological systems is, at the most basic level, driven by interactions between physical materials and their environment. In this context we are interested in falling paper systems, specifically the V-shaped falling paper (VSFP) system that exhibits a set of discrete falling behaviors across the morphological parameter space. Our previous work has investigated how morphology influences dominant falling behaviors in the VSFP system. In this article we build on this analysis to investigate the nature of behavioral transitions in the same system. First, we investigate stochastic behavior transitions. We demonstrate how morphology influences the likelihood of different transitions, with certain morphologies leading to a wide range of possible paths through the behavior-space. Second, we investigate deterministic transitions. To investigate behaviors over longer time periods than available in falling experiments we introduce a new experimental platform. We demonstrate how we can induce behavior transitions by modulating the energy input to the system. Certain behavior transitions are found to be irreversible, exhibiting a form of hysteresis, while others are fully reversible. Certain morphologies are shown to behave like simplistic sequential logic circuits, indicating that the system has a form of memory encoded into the morphology–environment interactions. Investigating the limits of how morphology–environment interactions induce non-trivial behaviors is a key step for the design of embodied artificial life-forms.

Research on a design method of pneumatic logic control system

Aiming at the complex characteristics of the sequential logic control system design, such as X-D diagram and karnaugh map method, a design method based on stepper module was proposed, the procedure of which does not need to be checked and corrected. The design of different pneumatic circuits was carried out with the automatic drilling machine as the application object. First, a stepper module composed of a two-position three-way valve and a dual-pressure valve was constructed, and its structure principle was analyzed in detail. Next, three kinds of stroke programs were listed by analyzing the working process of automatic drilling machine, which were multi-cylinder single reciprocating, multi-cylinder multi reciprocating and multi-cylinder multi-section reciprocating stroke program, and the pneumatic circuit control system was designed by the stepper module method. Finally, the pneumatic circuit was simulated and analyzed using the software Fluid-SIM. The simulation results showed that each actuator can complete the corresponding actions according to the design requirements, which verified the correctness and reliability of the stepper module design method. This work would provide a fast and effective method for the design of the sequential logic control system.

The Relation between Collaborative Consumption and Subjective Well-Being: An Analysis of P2P Accommodation

The present paper investigates the relationships between Collaborative Consumption (CC) and well-being. Specifically, the study aims to understand the antecedents of subjective well-being (SWB) in peer-to-peer (P2P) accommodation services. The research adopts a mixed-method approach by integrating qualitative (focus groups) and quantitative (survey) methods with sequential logic. A conceptual model was developed and validated through structural equation modelling (SEM). The model confirms that the SWB, which has three indirect antecedents (the social, environmental and economic dimensions), was positively influenced by the attitude towards P2P accommodation services, and the relation between this construct and SWB emphasizes the originality of the study. This research contributes to the current sharing economy debate, unveiling theoretical advances on the link between collaborative services and well-being.