scholarly journals Pair correlation of dilute active Brownian particles: From low-activity dipolar correction to high-activity algebraic depletion wings

2021 ◽  
Vol 103 (1) ◽  
Author(s):  
Alexis Poncet ◽  
Olivier Bénichou ◽  
Vincent Démery ◽  
Daiki Nishiguchi
1979 ◽  
Vol 42 (05) ◽  
pp. 1452-1459 ◽  
Author(s):  
Robert H Yue ◽  
Toby Starr ◽  
Menard M Gertler

SummaryCommercial porcine heparin can be separated into three distinct subtractions by using DEAE-cellulose chromatography and a stepped salt gradient. Gram quantities of heparin can be fractionated by this technique. All three heparin subtractions can accelerate the inhibition of thrombin by antithrombin III with different efficiency. The specific activities of the high activity heparin, intermediate activity heparin and low activity heparin are 228 units/mg, 142 units/mg and 95 units/mg, respectively. Both the uronic acid content and the quantity of N-SO4 for all three heparin subfractions have been evaluated. The high activity heparin has the lowest uronic acid and N-SO4 content. The successful separation of commercial heparin into three distinct subfractions by means of ion-exchange chromatography suggests that the net charge on these three heparin components will serve as a model system in the elucidation of the structure and activity relationship to the biological function of heparin.


2020 ◽  
Vol 75 (10) ◽  
pp. 1967-1973
Author(s):  
Deepika R Laddu ◽  
Neeta Parimi ◽  
Katie L Stone ◽  
Jodi Lapidus ◽  
Andrew R Hoffman ◽  
...  

Abstract Background Physical activity (PA) is important to maintaining functional independence. It is not clear how patterns of change in late-life PA are associated with contemporaneous changes in physical performance measures. Methods Self-reported PA, gait speed, grip strength, timed chair stand, and leg power were assessed in 3,865 men aged ≥ 65 years at baseline (2000–2002) and Year 7 (2007–2009). Group-based trajectory modeling, using up to four PA measures over this period, identified PA trajectories. Multivariate linear regression models (adjusted least square mean [95% confidence interval {CI}]) described associations between-PA trajectories and concurrent changes in performance. Results Three discrete PA patterns were identified, all with declining PA. Linear declines in each performance measure (baseline to Year 7) were observed across all three PA groups, but there was some variability in the rate of decline. Multivariate models assessing the graded response by PA trajectory showed a trend where the high-activity group had the smallest declines in performance while the low-activity group had the largest (p-for trend < .03). Changes in the high-activity group were the following: gait speed (−0.10 m/s [−0.12, −0.08]), grip strength (−3.79 kg [−4.35, −3.23]), and chair stands (−0.38 [−0.50, −0.25]), whereas changes in the low-activity group were the following: gait speed (−0.16 [−0.17, −0.14]), grip strength (−4.83 kg [−5.10, −4.55]), and chair stands (−0.53 [−0.59, −0.46]). Between-group differences in leg power trajectories across PA patterns were not significant. Conclusions Declines in functional performance were higher among those with lower PA trajectories, providing further evidence for the interrelationship between changes in PA and performance during old age.


2018 ◽  
Vol 23 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Tsunenori Isa ◽  
Yuya Ueda ◽  
Ryo Nakamura ◽  
Shogo Misu ◽  
Rei Ono

This study investigated the relationship of a gap between the intent to be physically active and actual participation in physical activity (‘intention–behavior gap’) and self-efficacy for physical activity during childhood. A self-report questionnaire was used to collect information from 946 children from the fourth and sixth grades in Japan on self-efficacy, intention, and physical activity. Children with an intention–behavior gap (high intent–low activity or low intent–high activity) had higher self-efficacy scores than those with low intent and low activity (27.66 or 27.65 vs. 21.69; p < .001). They had lower self-efficacy scores than those with high intent and high activity (27.66 or 27.65 vs. 30.56; p < .001). Children with an intention–behavior gap had lower self-efficacy for physical activity than those who intended to be and were physically active. Such children may benefit from education interventions that focus on improving self-efficacy.


2013 ◽  
Vol 38 ◽  
pp. 201-211 ◽  
Author(s):  
Filipe Manuel Clemente ◽  
Micael Santos Couceiro ◽  
Fernando Manuel Lourenço Martins ◽  
Monika Ognyanova Ivanova ◽  
Rui Mendes

Abstract The main objective of this study was to analyse the distance covered and the activity profile that players presented at the FIFA World Cup in 2010. Complementarily, the distance covered by each team within the same competition was analysed. For the purposes of this study 443 players were analysed, of which 35 were goalkeepers, 84 were external defenders, 77 were central defenders, 182 were midfielders, and 65 were forwards. Afterwards, a thorough analysis was performed on 16 teams that reached the group stage, 8 teams that achieved the round of 16, 4 teams that reached the quarter-finals, and 4 teams that qualified for the semi-finals and finals. A comparison of the mean distance covered per minute among the playing positions showed statistically significant differences (F(4,438) = 559.283; p < 0.001; 2 = 0.836; Power = 1.00). A comparison of the activity time among tactical positions also resulted in statistically significant differences, specifically, low activity (F(4,183.371) = 1476.844; p < 0.001; 2 = 0.742; Power = 1.00), medium activity (F(4,183.370) = 1408.106; p < 0.001; 2 = 0.731; Power = 1.00), and high activity (F(4,182.861) = 1152.508; p < 0.001; 2 = 0.703; Power = 1.00). Comparing the mean distance covered by teams, differences that are not statistically significant were observed (F(3,9.651) = 4.337; p < 0.035; 2 = 0.206; Power = 0.541). In conclusion, the tactical positions of the players and their specific tasks influence the activity profile and physical demands during a match.


2018 ◽  
Author(s):  
Jamie A. Macpherson ◽  
Alina Theisen ◽  
Laura Masino ◽  
Louise Fets ◽  
Paul C. Driscoll ◽  
...  

ABSTRACTAllosteric regulation is central to the role of the glycolytic enzyme pyruvate kinase M2 (PKM2) in cellular metabolism. Multiple activating and inhibitory allosteric ligands regulate PKM2 activity by controlling the equilibrium between high activity tetramers and low activity dimers and monomers. However, it remains elusive how allosteric inputs upon simultaneous binding of different ligands are integrated to regulate PKM2 activity. Here, we show that, in the presence of the allosteric inhibitor L-phenylalanine (Phe), the activator fructose 1,6-bisphosphate (FBP) can induce PKM2 tetramerisation, but fails to maximally increase enzymatic activity. Guided by a new computational framework we developed to identify residues that mediate FBP-induced allostery, we generated two PKM2 mutants, A327S and C358A, in which activation by FBP remains intact but cannot be attenuated by Phe. Our findings demonstrate a role for residues involved in FBP-induced allostery in enabling the integration of allosteric input from Phe and reveal a mechanism that underlies the co-ordinate regulation of PKM2 activity by multiple allosteric ligands.


1993 ◽  
Vol 103 (4) ◽  
pp. 1061-1066 ◽  
Author(s):  
M. Gijzen ◽  
R. van Huystee ◽  
R. I. Buzzell

1982 ◽  
Vol 202 (1) ◽  
pp. 171-174 ◽  
Author(s):  
Michio Matsui ◽  
Hiroshi K. Watanabe

Male and female Wistar rats with high and low hepatic microsomal UDP-glucuronosyltransferase activity towards androsterone were classified by partial hepatectomy. The breeding experiments between the classified high-activity and low-activity rats show that the genetic expression of the high transferase activity is inherited in an autosomal dominant fashion.


1969 ◽  
Vol 114 (3) ◽  
pp. 463-476 ◽  
Author(s):  
J. E. A. McIntosh

1. Three forms of the zinc-containing enzyme carbonic anhydrase (EC 4.2.1.1) were isolated from the erythrocytes of the rat and two forms from the dorsolateral prostate of the rat. Several additional minor components were observed but not isolated. Separation of the isoenzymes was achieved by ion-exchange chromatography, polyacrylamide-gel electrophoresis and isoelectric focusing. 2. The general properties of the isolated isoenzymes, their molecular weights and their contents of zinc were closely similar. As catalysts of the hydration of carbon dioxide, however, they were distinctly different. The two most abundant isoenzymes of the erythrocytes, which were found in equal proportions, differed 70-fold in specific activity, whereas the isoenzymes of the dorsolateral prostate were similar to one another and resembled the high-activity component of the erythrocytes. The inhibition of the latter by acetazolamide (5-acetamido-1-thia-3,4-diazole-2-sulphonamide) was mainly competitive, whereas in identical conditions the low-activity erythrocyte component and the dorsolateral prostate isoenzymes were non-competitively inhibited. 3. The use of chloroform–ethanol to remove haemoglobin from the rat haemolysate was found (a) to bring about changes in the kinetic properties of the soluble isoenzymes and (b) to cause the appearance of an additional isoenzyme. 4. The actions were compared of the inhibitors acetazolamide, 1,1-dimethylaminonaphthalene-5-sulphonamide and ethoxzolamide (6-ethoxybenzothiazole-2-sulphonamide) on the hydrolysis of p-nitrophenyl acetate catalysed by the isoenzymes. 5. The low-activity erythrocyte isoenzyme was an efficient catalyst of the hydrolysis of β-naphthyl acetate whereas the high-activity forms were much less active towards this ester. Neither of the isoenzymes present in the dorsolateral prostate catalysed this reaction. 6. Carbonic anhydrase in the rat dorsolateral prostate accounts for no more than 5% of the unusually high content of zinc in this organ.


1983 ◽  
Vol 61 (7) ◽  
pp. 729-735 ◽  
Author(s):  
S. J. Lye ◽  
Cher L. Sprague ◽  
J. R. G. Challis

Administration of estradiol-17β (E2; 50 μg s.c. per day) to nonpregnant ewes results in a cyclic pattern of uterine activity; periods of high activity (6- to 8-h duration) alternating with periods of low activity or quiescence (2–3 h). To examine the role of prostaglandins (PG) in this pattern five nonpregnant, bilaterally ovariectomized ewes were treated in turn with corn oil injected s.c. (control), E2 (50 μg s.c), and E2 (50 μg s.c.) plus 600 μg/min meclofenamic acid (MFA) i.v. Intrauterine pressure (IUP) and uterine electromyographic (EMG) activity were recorded continuously. Samples of blood from the inferior vena cava and abdominal aorta were collected every 30 min for one period of 16 h during each treatment. Following corn oil injection, uterine activity remained at the low level and there was no correlation between PG concentrations and uterine activity. After administration of E2, plasma E2 concentrations rose fivefold from basal values by 3.5 h after injection and returned to basal levels by 13 h. Administration of E2 resulted in the appearance of a cyclical pattern of uterine activity. Vena cava concentrations of 13,14-dihydro-15-keto PGF2α were positively correlated to the frequency (five out of five ewes), and the maximum amplitude (four out of five ewes) of IUP cycles, and were significantly elevated during high activity compared with low activity periods. Venous PGE concentrations did not show a consistent relation with uterine activity parameters. MFA reduced plasma PG concentrations below other treatments and also abolished the cyclical pattern of activity. These data suggest that PG's may play a role in the cycles of myometrial activity resultant upon E2 treatment of the ewe.


1998 ◽  
Vol 27 (5) ◽  
pp. 643-648 ◽  
Author(s):  
HELLE R. ANDERSEN ◽  
BERNARD JEUNE ◽  
HANNE NYBO ◽  
JESPER B. NIELSEN ◽  
KAREN ANDERSEN-RANBERG ◽  
...  

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