Structure and intermolecular interactions of glipizide from laboratory X-ray powder diffraction
2005 ◽
Vol 61
(6)
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pp. 710-716
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Keyword(s):
X Ray
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The crystal structure of glipizide, used as a major treatment of type-2 diabetes, has been determined ab initio using variable-temperature laboratory X-ray powder diffraction combined with a direct-space Monte Carlo/simulated annealing methodology. The strengths of the intermolecular interactions (van der Waals, π–π stacking, hydrogen bonding and steric interlock) were quantitatively estimated using the thermal expansion data, which were collected in the same set of experiments as those used to determine the structure.