Image guidance protocol for synchrotron microbeam radiation therapy

2016 ◽  
Vol 23 (2) ◽  
pp. 566-573 ◽  
Author(s):  
Daniele Pelliccia ◽  
Christopher M. Poole ◽  
Jayde Livingstone ◽  
Andrew W. Stevenson ◽  
Lloyd M. L. Smyth ◽  
...  
Keyword(s):  
Image Guidance ◽  
Experimental Validation ◽  
Low Dose ◽  
Operation Mode ◽  
Small Animal ◽  
Mode Change ◽  
Monochromatic Imaging ◽  
Imaging Results ◽  
Preclinical Trials ◽  
Sample Alignment

The protocol for image-guided microbeam radiotherapy (MRT) developed for the Australian Synchrotron's Imaging and Medical Beamline (IMBL) is described. The protocol has been designed for the small-animal MRT station of IMBL to enable future preclinical trials on rodents. The image guidance procedure allows for low-dose monochromatic imaging at 50 keV and subsequent semi-automated sample alignment in 3D with sub-100 µm accuracy. Following the alignment, a beamline operation mode change is performed and the relevant beamline components are automatically aligned for the treatment (pink) beam to be delivered on the sample. Here, the small-animal MRT station, the parameters and procedures for the image guidance protocol, as well as the experimental imaging results using phantoms are described. Furthermore, the experimental validation of the protocol using 3D PRESAGE®dosimeters is reported. It is demonstrated that the sample alignment is maintained after the mode change and the treatment can be delivered within the same spatial accuracy of 100 µm. The results indicate that the proposed approach is viable for preclinical trials of small-animal MRT.

Sci-Fri PM: Delivery - 12: Performance of Two Automated Image Guidance Techniques Employing Low Dose CBCT

2010 ◽  
Vol 37 (7Part3) ◽  
pp. 3906-3906
Author(s):  
M Wierzbicki ◽  
B Schaly
Keyword(s):  
Image Guidance ◽  
Low Dose

LOW DOSE, LOW ENERGY 3D IMAGE GUIDANCE DURING RADIOTHERAPY

2006 ◽  
Author(s):  
C. J. MOORE ◽  
T. MARCHANT ◽  
A. AMER ◽  
P. SHARROCK ◽  
P. PRICE ◽  
...  
Keyword(s):  
Image Guidance ◽  
Low Dose ◽  
Low Energy ◽  
3D Image

Poster - Wed Eve-55: Automated Image Guidance for Prostate IMRT Using Low Dose Cone Beam CT

2009 ◽  
Vol 36 (9Part3) ◽  
pp. 4314-4314
Author(s):  
M Wierzbicki ◽  
B Schaly ◽  
R Barnett
Keyword(s):  
Image Guidance ◽  
Low Dose ◽  
Cone Beam Ct ◽  
Cone Beam

WE-A-217A-11: Fast and Low-Dose 4DCBCT for Small Animal Lung Ventilation Study

2012 ◽  
Vol 39 (6Part26) ◽  
pp. 3938-3938
Author(s):  
Z Qi ◽  
Q Chen ◽  
K Ding ◽  
S Benedict ◽  
L Lernen ◽  
...  
Keyword(s):  
Low Dose ◽  
Small Animal ◽  
Lung Ventilation

scholarly journals Non-Invasive Targeted Hepatic Irradiation and SPECT/CT Functional Imaging to Study Radiation-Induced Liver Damage in Small Animal Models

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1796
Author(s):  
Rafi Kabarriti ◽  
N. Patrik Brodin ◽  
Hillary Yaffe ◽  
Mark Barahman ◽  
Wade R. Koba ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Image Guidance ◽  
Single Photon ◽  
Photon Emission ◽  
Small Animal ◽  
Emission Computed Tomography ◽  
Cancer Treatments ◽  
Non Invasive ◽  
Radiation Induced ◽  
Computed Tomography Image

Radiation therapy (RT) has traditionally not been widely used in the management of hepatic malignancies for fear of toxicity in the form of radiation-induced liver disease (RILD). Pre-clinical hepatic irradiation models can provide clinicians with better understanding of the radiation tolerance of the liver, which in turn may lead to the development of more effective cancer treatments. Previous models of hepatic irradiation are limited by either invasive laparotomy procedures, or the need to irradiate the whole or large parts of the liver using external skin markers. In the setting of modern-day radiation oncology, a truly translational animal model would require the ability to deliver RT to specific parts of the liver, through non-invasive image guidance methods. To this end, we developed a targeted hepatic irradiation model on the Small Animal Radiation Research Platform (SARRP) using contrast-enhanced cone-beam computed tomography image guidance. Using this model, we showed evidence of the early development of region-specific RILD through functional single photon emission computed tomography (SPECT) imaging.

OC-0312 CT-less 3D image guidance for high-precision small animal particle irradiation

2021 ◽  
Vol 161 ◽  
pp. S221-S222
Author(s):  
M. Boucsein ◽  
J. Müller ◽  
T. Suckert ◽  
E. Beyreuther ◽  
M. Alber ◽  
...  
Keyword(s):  
High Precision ◽  
Image Guidance ◽  
Small Animal ◽  
3D Image ◽  
Particle Irradiation

scholarly journals Gadoxetate-enhanced dynamic contrast-enhanced MRI for evaluation of liver function and liver fibrosis in preclinical trials

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jimi Huh ◽  
Su Jung Ham ◽  
Young Chul Cho ◽  
Bumwoo Park ◽  
Bohyun Kim ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Clinical Research ◽  
Low Dose ◽  
Correlation Coefficients ◽  
High Dose ◽  
Dce Mri ◽  
Contrast Enhanced ◽  
Preclinical Trials ◽  
Icg R15 ◽  
And Control

Abstract Background To facilitate translational drug development for liver fibrosis, preclinical trials need to be run in parallel with clinical research. Liver function estimation by gadoxetate-enhanced dynamic contrast-enhanced MRI (DCE-MRI) is being established in clinical research, but still rarely used in preclinical trials. We aimed to evaluate feasibility of DCE-MRI indices as translatable biomarkers in a liver fibrosis animal model. Methods Liver fibrosis was induced in Sprague-Dawley rats by thioacetamide (200 mg, 150 mg, and saline for the high-dose, low-dose, and control groups, respectively). Subsequently, DCE-MRI was performed to measure: relative liver enhancement at 3-min (RLE-3), RLE-15, initial area-under-the-curve until 3-min (iAUC-3), iAUC-15, and maximum-enhancement (Emax). The correlation coefficients between these MRI indices and the histologic collagen area, indocyanine green retention at 15-min (ICG-R15), and shear wave elastography (SWE) were calculated. Diagnostic performance to diagnose liver fibrosis was also evaluated by receiver-operating-characteristic (ROC) analysis. Results Animal model was successful in that the collagen area of the liver was the largest in the high-dose group, followed by the low-dose group and control group. The correlation between the DCE-MRI indices and collagen area was high for iAUC-15, Emax, iAUC-3, and RLE-3 but moderate for RLE-15 (r, − 0.81, − 0.81, − 0.78, − 0.80, and − 0.51, respectively). The DCE-MRI indices showed moderate correlation with ICG-R15: the highest for iAUC-15, followed by iAUC-3, RLE-3, Emax, and RLE-15 (r, − 0.65, − 0.63, − 0.62, − 0.58, and − 0.56, respectively). The correlation coefficients between DCE-MRI indices and SWE ranged from − 0.59 to − 0.28. The diagnostic accuracy of RLE-3, iAUC-3, iAUC-15, and Emax was 100% (AUROC 1.000), whereas those of RLE-15 and SWE were relatively low (AUROC 0.777, 0.848, respectively). Conclusion Among the gadoxetate-enhanced DCE-MRI indices, iAUC-15 and iAUC-3 might be bidirectional translatable biomarkers between preclinical and clinical research for evaluating histopathologic liver fibrosis and physiologic liver functions in a non-invasive manner.

An x-ray image guidance system for small animal stereotactic irradiation

2010 ◽  
Vol 55 (23) ◽  
pp. 7345-7362 ◽  
Author(s):  
K H Song ◽  
R Pidikiti ◽  
S Stojadinovic ◽  
M Speiser ◽  
S Seliounine ◽  
...  
Keyword(s):  
Image Guidance ◽  
Small Animal ◽  
Guidance System ◽  
Stereotactic Irradiation ◽  
X Ray

scholarly journals Ultrafast contour imaging for time-domain diffuse optical tomography

2020 ◽  
Author(s):  
Xiaohua Feng ◽  
Liang Gao
Keyword(s):  
Time Domain ◽  
Collection Efficiency ◽  
Signal To Noise Ratio ◽  
Optical Tomography ◽  
Small Animal Imaging ◽  
Diffuse Optical Tomography ◽  
Small Animal ◽  
Depth Of Field ◽  
Light Collection ◽  
Imaging Results

Diffuse optical tomography (DOT) is well known to be ill-posed and suffers from a poor resolution. While time domain DOT can bolster the resolution by time-gating to extract weakly scattering photons, it is often confronted by an inferior signal to noise ratio and a low measurement density. This is particularly problematic for non-contact DOT imaging of non-planar objects, which faces an inherent tradeoff between the light collection efficiency and depth of field. We present here ultrafast contour imaging, a method that enables efficient light collection over curved surfaces with a dense spatiotemporal sampling of diffused light, allowing DOT imaging in the object’s native geometry with an improved resolution. We demonstrated our approach with both phantom and small animal imaging results. ©2020 Optical Society of America

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