Exploring the complex map of insulin polymorphism: a novel crystalline form in the presence of m-cresol
2020 ◽
Vol 76
(4)
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pp. 366-374
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Keyword(s):
X Ray
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In this study, the first crystal structure of a novel crystal form of human insulin bound to meta-cresol in an acidic environment is reported. The combination of single-crystal and powder X-ray diffraction crystallography led to the detection of a previously unknown monoclinic phase (P21). The structure was identified from the powder patterns and was solved using single-crystal diffraction data at 2.2 Å resolution. The unit-cell parameters at pH 6.1 are a = 47.66, b = 70.36, c = 84.75 Å, β = 105.21°. The structure consists of two insulin hexamers per asymmetric unit. The potential use of this insulin form in microcrystalline drugs is discussed.
1999 ◽
Vol 55
(9)
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pp. 1616-1617
1998 ◽
Vol 54
(4)
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pp. 358-364
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2012 ◽
Vol 76
(7)
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pp. 2773-2783
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2017 ◽
Vol 81
(2)
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pp. 339-354
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