The on-orbit mission analysis of OTV based on DoDAF

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Hongxing Zheng ◽  
Xin Liu ◽  
Junhui Wu ◽  
Yiyun Man ◽  
Xibao Xu ◽  
...  
Keyword(s):  
Functional Requirements ◽  
Orbit Transfer ◽  
Content Type ◽  
Mission Analysis ◽  
Bottom Level ◽  
Relationship Analysis ◽  
Architecture Framework ◽  
Upper Stage ◽  
High Level ◽  
Level Analysis

Purpose The purpose of this paper is to improve the efficiency of on-orbit operations through the top-level task design based on DoDAF. Based on the existing upper stage rocket technology, orbit transfer vehicles (OTVs) have developed rapidly in recent years. However, the lack of decision guidance based on overall task analysis requires integrating top-level analysis and bottom-level execution to achieve the smooth development of full-process tasks. Design/methodology/approach Using the Department of Defense Architecture Framework (DoDAF) as a reference, this paper performs the top-level mission analysis modeling of the on-orbit rendezvous and capture of the OTV. Moreover, the typical operational view products are obtained, and the cooperative relations among the mission requirements, the system requirements, and the functional requirements are also analyzed. Findings The results show that the attitude of the OTV changes violently during the maneuver and rendezvous phases. In addition, the view products can be optimized based on the results. Originality/value The proposed DoDAF-based on-orbit task integration analysis method achieves the effective fusion of high-level analysis and bottom-level execution of OTV on-orbit rendezvous and capture task through the top-level task modeling, operation view generation and task relationship analysis. According to the requirements and constraints of the on-orbit rendezvous and capture task, the control instructions of the vehicle are efficiently generated under the DoDAF framework.

Cross-cultural application of a practice-oriented acquiescence measure

2019 ◽  
Vol 36 (3) ◽  
pp. 391-415 ◽  
Author(s):  
Carolin Krautz ◽  
Stefan Hoffmann
Keyword(s):  
Large Scale ◽  
Power Distance ◽  
Cross Cultural ◽  
Cultural Dimensions ◽  
Content Type ◽  
Country Level ◽  
Consumer Study ◽  
Multi Level ◽  
High Level ◽  
Level Analysis

Purpose Extant research shows that acquiescence response style (ARS) is culture-bound and may bias the results of comparative cross-cultural studies. Conventional measures of ARS are difficult to apply in practice. To overcome this limitation, the purpose of this paper is to propose an alternative, practice-oriented measure, namely, pARS. The authors apply Hofstede’s cultural dimensions (Hofstede et al., 2010) to test whether pARS is culture-bound. The cross-cultural study provides a high level of cross-cultural generalisability due to the extensive number of surveyed countries (n=30) and subjects (n=236.089). The authors run multi-level analysis to identify within- and between-country-level predictors. Design/methodology/approach On the individual level, the authors use data of a large-scale cross-cultural study, including 236.089 consumers from 30 countries worldwide. The authors apply several methods to test for the culture-boundness of pARS. First, they apply correlation analysis to replicate existing cross-cultural results and to ensure nomological validity. Second, applying ordinary least square regression, the authors simultaneously test the six Hofstede cultural dimensions (Hofstede et al., 2010) and investigate interactions between the dimensions. Finally, they use multi-level analysis to confirm the stability of culture-bound results, controlling for individual- and country-level variability. Findings The paper introduces an alternative measure for acquiescence (pARS), which is particularly suitable for shorter questionnaires. A large-scale consumer study with 236.089 respondents in 30 countries supports the culture-bound validity of pARS. The authors confirm construct validity and the nomological network of pARS. Contrasting existing studies, multi-level analysis demonstrates that a high level of power distance majorly leads to ARS. Therefore, cross-cultural researchers need to control for ARS in countries high in power distance, especially when paired with high uncertainty avoidance. Originality/value A large-scale consumer study with 236.089 respondents from 30 countries shows that respondents from various countries differ significantly in their level of acquiescence. The study confirms that power distance is the most relevant cultural dimension to explain these differences. Although ARS may bias the results of comparative cross-cultural studies, it is rarely controlled by market research studies outside the academic realm. The present work proposes and establishes the validity of a practice-oriented measure of acquiescence, namely, pARS. pARS is particularly suitable for shorter questionnaires. In contrast to prior approaches, applying pARS does not require adding non-substantive items to the questionnaire.

Understanding context in diversity management: a multi-level analysis

2015 ◽  
Vol 34 (6) ◽  
pp. 470-482 ◽  
Author(s):  
Judith K. Pringle ◽  
Irene Ryan
Keyword(s):  
Diversity Management ◽  
Analytical Framework ◽  
Reciprocal Relationship ◽  
Theory And Practice ◽  
Power Dynamics ◽  
Content Type ◽  
Relationship Analysis ◽  
Multi Level ◽  
Diversity Studies ◽  
Level Analysis

Purpose – The purpose of this paper is to operationalize context in diversity management research. Design/methodology/approach – A case analysis provides an example of the influences of context at macro, meso and micro levels. Country context (macro) and professional and organization contexts (meso) are analysed in relation to the micro individual experiences of gender and indigeneity at work. Findings – Tensions and inconsistencies at macro and meso levels impact on diversity management at a micro level. The authors demonstrate how power and context are intertwined in the biopolitical positioning of subjects in terms of gender and indigeneity. The contested legacy of indigenous-colonial relations and societal gender dynamics are “played out” in a case from the accounting profession. Research limitations/implications – Within critical diversity studies context and power are linked in a reciprocal relationship; analysis of both is mandatory to strengthen theory and practice. The multi-level analytical framework provides a useful tool to understand advances and lack of progress for diversity groups within specific organizations. Originality/value – While many diversity scholars agree that the analysis of context is important, hitherto its application has been vague. The authors conduct a multi-level analysis of context, connecting the power dynamics between the levels. The authors draw out implications within one profession in a specific country socio-politics. Multi-level analyses of context and power have the potential to enhance the theory and practice of diversity management.

scholarly journals Mutations in fbiD (Rv2983) as a Novel Determinant of Resistance to Pretomanid and Delamanid in Mycobacterium tuberculosis

2020 ◽  
Vol 65 (1) ◽  
pp. e01948-20
Author(s):  
Dalin Rifat ◽  
Si-Yang Li ◽  
Thomas Ioerger ◽  
Keshav Shah ◽  
Jean-Philippe Lanoix ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Clinical Evidence ◽  
Clinical Samples ◽  
Loss Of Function ◽  
Wild Type ◽  
Content Type ◽  
Solid Media ◽  
High Level ◽  
Level Resistance

ABSTRACTThe nitroimidazole prodrugs delamanid and pretomanid comprise one of only two new antimicrobial classes approved to treat tuberculosis (TB) in 50 years. Prior in vitro studies suggest a relatively low barrier to nitroimidazole resistance in Mycobacterium tuberculosis, but clinical evidence is limited to date. We selected pretomanid-resistant M. tuberculosis mutants in two mouse models of TB using a range of pretomanid doses. The frequency of spontaneous resistance was approximately 10−5 CFU. Whole-genome sequencing of 161 resistant isolates from 47 mice revealed 99 unique mutations, of which 91% occurred in 1 of 5 genes previously associated with nitroimidazole activation and resistance, namely, fbiC (56%), fbiA (15%), ddn (12%), fgd (4%), and fbiB (4%). Nearly all mutations were unique to a single mouse and not previously identified. The remaining 9% of resistant mutants harbored mutations in Rv2983 (fbiD), a gene not previously associated with nitroimidazole resistance but recently shown to be a guanylyltransferase necessary for cofactor F420 synthesis. Most mutants exhibited high-level resistance to pretomanid and delamanid, although Rv2983 and fbiB mutants exhibited high-level pretomanid resistance but relatively small changes in delamanid susceptibility. Complementing an Rv2983 mutant with wild-type Rv2983 restored susceptibility to pretomanid and delamanid. By quantifying intracellular F420 and its precursor Fo in overexpressing and loss-of-function mutants, we provide further evidence that Rv2983 is necessary for F420 biosynthesis. Finally, Rv2983 mutants and other F420H2-deficient mutants displayed hypersusceptibility to some antibiotics and to concentrations of malachite green found in solid media used to isolate and propagate mycobacteria from clinical samples.

scholarly journals EthIR: A Framework for High-Level Analysis of Ethereum Bytecode

2018 ◽  
pp. 513-520 ◽  
Author(s):  
Elvira Albert ◽  
Pablo Gordillo ◽  
Benjamin Livshits ◽  
Albert Rubio ◽  
Ilya Sergey
Keyword(s):  
High Level ◽  
Level Analysis

scholarly journals Understanding employee turnover in humanitarian organizations

2016 ◽  
Vol 48 (4) ◽  
pp. 208-214 ◽  
Author(s):  
Rameshwar Dubey ◽  
Angappa Gunasekaran ◽  
Nezih Altay ◽  
Stephen J Childe ◽  
Thanos Papadopoulos
Keyword(s):  
Employee Turnover ◽  
Factor Loading ◽  
Personal Factors ◽  
Related Factors ◽  
Content Type ◽  
Factors Affecting ◽  
Work Related ◽  
Humanitarian Organizations ◽  
Using Data ◽  
High Level

Purpose – At a time when the number and seriousness of disasters seems to be increasing, humanitarian organizations find that besides their challenging work they are faced with problems caused by a high level of turnover of staff. The paper aims to discuss these issues. Design/methodology/approach – Based on the 24 variables leading to employee turnover identified by Cotton and Tuttle (1986) the authors analyse the work-related, external and personal factors affecting employee turnover in humanitarian organizations, using a survey of members of the Indian National Institute of Disaster Management. Findings – Results indicated that the three factors are present. Of the external factors, only employment perception had a factor loading over 0.7; of the work-related factors, all were significant; of the personal factors, biographical information, marital status, number of dependants, aptitude and ability and intelligence had the highest loadings. It was also shown that behavioural intentions and net expectation were not significant. Originality/value – Only a few studies reported on employee turnover and its reasons are not well understood in the context of humanitarian organizations. To address this need, the aim of this paper is to explore the personal reasons impacting employee turnover in humanitarian organizations. In the study the authors have adopted 24 variables used in Cotton and Tuttle (1986) and classified into constructs to explain turnover, and further tested the model using data gathered from humanitarian organizations.

scholarly journals Whole-Genome Phylogenomic Heterogeneity of Neisseria gonorrhoeae Isolates with Decreased Cephalosporin Susceptibility Collected in Canada between 1989 and 2013

2014 ◽  
Vol 53 (1) ◽  
pp. 191-200 ◽  
Author(s):  
Walter Demczuk ◽  
Tarah Lynch ◽  
Irene Martin ◽  
Gary Van Domselaar ◽  
Morag Graham ◽  
...  
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Large Scale ◽  
Epidemiological Studies ◽  
23S Rrna ◽  
Genome Comparison ◽  
Whole Genome ◽  
Content Type ◽  
Genomic Epidemiology ◽  
High Level ◽  
Sequence Types

A large-scale, whole-genome comparison of CanadianNeisseria gonorrhoeaeisolates with high-level cephalosporin MICs was used to demonstrate a genomic epidemiology approach to investigate strain relatedness and dynamics. Although current typing methods have been very successful in tracing short-chain transmission of gonorrheal disease, investigating the temporal evolutionary relationships and geographical dissemination of highly clonal lineages requires enhanced resolution only available through whole-genome sequencing (WGS). Phylogenomic cluster analysis grouped 169 Canadian strains into 12 distinct clades. While someN. gonorrhoeaemultiantigen sequence types (NG-MAST) agreed with specific phylogenomic clades or subclades, other sequence types (ST) and closely related groups of ST were widely distributed among clades. Decreased susceptibility to extended-spectrum cephalosporins (ESC-DS) emerged among a group of diverse strains in Canada during the 1990s with a variety of nonmosaicpenAalleles, followed in 2000/2001 with thepenAmosaic X allele and then in 2007 with ST1407 strains with thepenAmosaic XXXIV allele. Five genetically distinct ESC-DS lineages were associated withpenAmosaic X, XXXV, and XXXIV alleles and nonmosaic XII and XIII alleles. ESC-DS with coresistance to azithromycin was observed in 5 strains with 23S rRNA C2599T or A2143G mutations. As the costs associated with WGS decline and analysis tools are streamlined, WGS can provide a more thorough understanding of strain dynamics, facilitate epidemiological studies to better resolve social networks, and improve surveillance to optimize treatment for gonorrheal infections.

Living in the end times: a short course addressing end of life issues for older people in an English parish church setting

2015 ◽  
Vol 19 (3) ◽  
pp. 140-149 ◽  
Author(s):  
Joanna Collicutt
Keyword(s):  
Older People ◽  
End Of Life ◽  
Group Dynamics ◽  
Death And Dying ◽  
Community Context ◽  
Content Type ◽  
End Of Life Issues ◽  
End Times ◽  
High Level ◽  
High Degree

Purpose – The purpose of this paper is to report a pilot study that evaluated an innovative practice in a faith community context designed to help older people live well at the end of life and prepare for death. Design/methodology/approach – A simple audit of the intervention using a contemporaneous journal kept by the author, and a follow up questionnaire completed by participants. Findings – Rich findings on the process are reported. These indicate a high degree of engagement by participants, the establishment of a high degree of group intimacy and trust, a high level of articulation of wisdom, the emergence of significant anxiety in some isolated cases, and the use made of tea and cake to manage the transition between the existentially demanding nature of the discussions and normal life. The outcome indicated very high levels of appreciation and increased confidence in relation to issues of death and dying. Practical implications – The findings of the pilot have been used to inform training of clergy in the principles of working in this area (e.g. in ways of managing group dynamics and anxiety, pacing, tuning in to archetypes and the natural symbols that people use to talk about death and dying, self-care and supervision of the programme leader/facilitator). Originality/value – The paper adds to knowledge in terms of an in depth description of processes at work in a group of older people working on spiritual and practical issues in relation to death, and offers ideas for supporting older people in this process, some of which are specific to the Christian tradition, and some of which are more widely applicable to people of all faiths and none. It gives a specific worked example of what “spiritual care” in this area might look like.

Flexible contracting in project business

2015 ◽  
Vol 8 (1) ◽  
pp. 92-106 ◽  
Author(s):  
Jaakko Kujala ◽  
Soili Nystén-Haarala ◽  
Jouko Nuottila
Keyword(s):  
Oral Communication ◽  
Underlying Assumption ◽  
Content Type ◽  
Iterative Development ◽  
Flexible Adaptation ◽  
Contracting Process ◽  
High Level ◽  
Project Lifecycle ◽  
Project Contract ◽  
Formal Contract

Purpose – The purpose of this paper is to increase the understanding of the main challenges of the contracting process and project contracts in the context of project business characterized by a high level of complexity and uncertainty. The authors argue that understanding contracting as a flexible process and as a business tool will contribute to creating more value in projects which are implemented in constantly changing circumstances or which require gradual and iterative development. Design/methodology/approach – This is a conceptual paper with illustrative examples from the software industry. Findings – A prevailing approach for both managing contracts and the contracting process focuses on careful planning and drafting of contracts that protect each party in the case of conflicts and disagreements. The underlying assumption is that all activities can be planned and documented in a formal contract. According to this approach, the contracting process is seen only as a bargaining negotiation and the project contract as a detailed agreement of the responsibilities and safeguarding clauses to protect one’s position in the event of conflicts and failures. However, in the context of project business characterized by complexity and uncertainty, there is a need for flexible project contracts. The authors suggest that there are two fundamentally different approaches to implementing flexibility in both the contracting process and the project contract: postponing the decision until there is adequate information for decision making or making decisions that allow flexible adaptation to changes during the project lifecycle. Practical implications – The authors suggest that organizations in project business should pay closer attention to how contracts are formed and how flexibility is introduced to projects. Organizations are encouraged to see contracts as a business tool, not as rigid documents which are taken into use in case something goes wrong. Originality/value – This paper contributes to the understanding of how to adapt the contracting process to overcome challenges related to uncertainty, especially during the early phases of the project lifecycle. The authors provide a novel perspective on contracting as a process that extends over the lifecycle of a project and on the project contract as an agreement between parties formed during the contracting process. This perspective includes formal contract documents as well as various other documents, oral communication, commitments, actions and incidents.

Evaluation of brain-stem dysfunction following severe fluid-percussion head injury to the cat

1991 ◽  
Vol 74 (2) ◽  
pp. 270-277 ◽  
Author(s):  
Katsuji Shima ◽  
Anthony Marmarou
Keyword(s):  
Brain Stem ◽  
Content Type ◽  
Fluid Percussion ◽  
Fluid Percussion Injury ◽  
Brain Stem Injury ◽  
Group 2 ◽  
High Level ◽  
Subarachnoid Hemorrhages ◽  
Fine Print ◽  
Group 1

✓ The degree of brain-stem dysfunction associated with high-level fluid-percussion injury (3.0 to 3.8 atm) was investigated in anesthetized cats. Measurements were made of the animals' intracranial pressure (ICP), pressure-volume index (PVI), far-field brain-stem auditory evoked responses (BAER's), and cerebral blood flow (CBF). The animals were classified into two groups based on the severity of neuropathological damage to the brain stem after trauma: Group 1 had mild intraparenchymal and subarachnoid hemorrhages and Group 2 had severe intraparenchymal and subarachnoid hemorrhages. The ICP values in Group 1 were insignificantly lower than those in Group 2, while the PVI values in Group 2 were clearly lower (p < 0.05). Immediately after the injury, peaks II, III, and IV of the BAER's demonstrated a transitory and marked suppression. One Group 1 and two Group 2 animals showed the disappearance of peak V. In Group 1, the latencies of peak II, III, and IV gradually increased until 60 to 150 minutes postinjury, then returned to 95% of baseline value at 8 hours; however, the animals in Group 2 showed poor recovery of latencies. Two hours after brain injury, the CBF decreased to 40% of the preinjury measurement in both groups (p < 0.001). In contrast to Group 2, the CBF in Group 1 returned to 86.8% of the preinjury measurement by 8 hours following the injury. Changes in PVI, BAER, and CBF correlated well with the degree of brain-stem injury following severe head injury'- These data indicate that high-level fluid-percussion injury (> 3.0 atm) is predominantly a model of brain-stem injury.

scholarly journals ArmA Methyltransferase in a Monophasic Salmonella enterica Isolate from Food

2011 ◽  
Vol 55 (11) ◽  
pp. 5262-5266 ◽  
Author(s):  
Sophie A. Granier ◽  
Laura Hidalgo ◽  
Alvaro San Millan ◽  
Jose Antonio Escudero ◽  
Belen Gutierrez ◽  
...  
Keyword(s):  
16S Rrna ◽  
Salmonella Enterica ◽  
Multidrug Resistant ◽  
Broad Host Range ◽  
En Bloc ◽  
Content Type ◽  
Route Of Transmission ◽  
Amoxicillin Clavulanate ◽  
High Level ◽  
Level Resistance

ABSTRACTThe 16S rRNA methyltransferase ArmA is a worldwide emerging determinant that confers high-level resistance to most clinically relevant aminoglycosides. We report here the identification and characterization of a multidrug-resistantSalmonella entericasubspecies I.4,12:i:− isolate recovered from chicken meat sampled in a supermarket on February 2009 in La Reunion, a French island in the Indian Ocean. Susceptibility testing showed an unusually high-level resistance to gentamicin, as well as to ampicillin, expanded-spectrum cephalosporins and amoxicillin-clavulanate. Molecular analysis of the 16S rRNA methyltransferases revealed presence of thearmAgene, together withblaTEM-1,blaCMY-2, andblaCTX-M-3. All of these genes could be transferreden blocthrough conjugation intoEscherichia coliat a frequency of 10−5CFU/donor. Replicon typing and S1 pulsed-field gel electrophoresis revealed that thearmAgene was borne on an ∼150-kb broad-host-range IncP plasmid, pB1010. To elucidate howarmAhad integrated in pB1010, a PCR mapping strategy was developed for Tn1548, the genetic platform forarmA.The gene was embedded in a Tn1548-like structure, albeit with a deletion of the macrolide resistance genes, and an IS26was inserted within themelgene. To our knowledge, this is the first report of ArmA methyltransferase in food, showing a novel route of transmission for this resistance determinant. Further surveillance in food-borne bacteria will be crucial to determine the role of food in the spread of 16S rRNA methyltransferase genes worldwide.

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