1996 ◽  
Vol 75 (04) ◽  
pp. 546-550 ◽  
Author(s):  
Marianne Schwartz ◽  
Albert Békássy ◽  
Mikael Donnér ◽  
Thomas Hertel ◽  
Stefan Hreidarson ◽  
...  

SummaryTwelve different mutations in the WASP gene were found in twelve unrelated families with Wiskott-Aldrich syndrome (WAS) or X-linked thrombocytopenia (XLT). Four frameshift, one splice, one nonsense mutation, and one 18-base-pair deletion were detected in seven patients with WAS. Only missense mutations were found in five patients diagnosed as having XLT. One of the nucleotide substitutions in exon 2 (codon 86) results in an Arg to Cys replacement. Two other nucleotide substitutions in this codon, R86L and R86H, have been reported previously, both giving rise to typical WAS symptoms, indicating a mutational hot spot in this codon. The finding of mutations in the WASP gene in both WAS and XLT gives further evidence of these syndromes being allelic. The relatively small size of the WASP gene facilitates the detection of mutations and a reliable diagnosis of both carriers and affected fetuses in families with WAS or XLT.


2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Fatima Ameen ◽  
Ziad Mohammed ◽  
Abdulrahman Siddiq

Tracking systems of moving objects provide a useful means to better control, manage and secure them. Tracking systems are used in different scales of applications such as indoors, outdoors and even used to track vehicles, ships and air planes moving over the globe. This paper presents the design and implementation of a system for tracking objects moving over a wide geographical area. The system depends on the Global Positioning System (GPS) and Global System for Mobile Communications (GSM) technologies without requiring the Internet service. The implemented system uses the freely available GPS service to determine the position of the moving objects. The tests of the implemented system in different regions and conditions show that the maximum uncertainty in the obtained positions is a circle with radius of about 16 m, which is an acceptable result for tracking the movement of objects in wide and open environments.


2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Raid Daoud ◽  
Yaareb Al-Khashab

The internet service is provided by a given number of servers located in the main node of internet service provider (ISP). In some cases; the overload problem was occurred because a demand on a given website goes to very high level. In this paper, a fuzzy logic control (FLC) has proposed to distribute the load into the internet servers by a smart and flexible manner. Three effected parameters are tacked into account as input for FLC: link capacity which has three linguistic variables with Gaussian membership function (MF): (small, medium and big), traffic density with linguistic variables (low, normal and high) and channel latency with linguistic variables (empty, half and full); with one output which is the share server status (single, simple and share). The proposed work has been simulated by using MATLAB 2016a, by building a structure in the Fuzzy toolbox. The results were fixed by two manners: the graphical curves and the numerical tables, the surface response was smoothly changed and translates the well-fixed control system. The numerical results of the control system satisfy the idea of the smart rout for the incoming traffics from the users to internet servers. So, the response of the proposed system for the share of server ratio is 0.122, when the input parameter in the smallest levels; and the ratio is 0.879 when the input parameters are in highest level. The smart work and flexible use for the FLC is the main success solution for most of today systems control.


2013 ◽  
Vol 10 (3) ◽  
pp. 342-358 ◽  
Author(s):  
Apostolos G. Papadopoulos ◽  
Christos Chalkias ◽  
Loukia-Maria Fratsea

The paper explores the challenges faced today, in a context of severe economic crisis, by immigrant associations (ΙΜΑs) and Non-Governmental Organizations (NGOs) in Greece. The data analysed here was collected between October 2009 and February 2010 and incorporates references to all recorded migration-related social actors operating in Greece. The paper takes into account such indicators as legal form, objectives, financial capacity and geographical range of activity, concluding with a typology of civil society actors dealing with migration issues. This study aims at informing the migration policymaking and migrant integration processes. By a spatial hot-spot clustering of IMAs and NGOs, we also illustrate the concentration patterns of civil society actors in Greece.


2020 ◽  
pp. 116-122
Author(s):  
Emre Öztürk ◽  
Mehmet Aktaş ◽  
Tunç Şenyüz

The purpose of this research is to reach good correlation between sun load simulation and solar focusing test for exterior automotive lighting products. Light coming from sun is highly collimated (parallel rays) and focusable from lenses with concave structure. Focusing incidence leads to a hot spot on lens surrounding plastic parts which may cause melting failures at high temperature zones. Sun load simulation is performing to eliminate risk of discoloration, deformation, out gassing, coating failures and fire with prolonged exposure from field. Irradiance values in W/m2 defined in simulation as heat source depending of an angle of incidence of the sun radiation. At first step, simulation is performing with 5 degree intervals to define the critical zones then intervals decreased to 2 degree to detect the critical azimuth and inclination angles. Critical azimuth and inclination angles is checking with ray trace analysis to check the bouncing of sun rays and possible solution to eliminate focuses with design solutions. After numerical analysis to release and validate the automotive lighting products regarding the sun load test, measurement with first parts is necessary. Measurement is performing for all critical angles which have been detected at simulation with thermal camera under ultra high-collimation solar simulator. Measured temperatures are settled according to environment conditions and correlation is checking with simulations.


ADALAH ◽  
2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Munadhil Abdul Muqsith

Abstract:The internet developed for the first time in Indonesia in the early 1990s. Starting from the pagayuban network, it is now expanding without boundaries anywhere. A survey conducted by the Indonesian Internet Service Providers Association (APJII) said that the number of internet users in Indonesia in 2012 reached 63 million people or 24.23 percent of the country's total population. Next year, that figure is predicted to increase by close to 30 percent to 82 million users and continue to grow to 107 million in 2014 and 139 million or 50 percent of the total population in 2015. million people. This matter also results in political communication with the internet media, or is often said to be cyber politics. Cyber politics in Indonesia has faced growth in recent years. There are many facilities that support the growth of cyber politics, such as Facebook, Twitter, mailing list, YouTube, and others.Keywords: Cyberpolitik, Internet  Abstrak:Internet berkembang pertama kali di Indonesia pada awal tahun 1990-an. Diawali dari pagayuban network kini berkembang luas tanpa batas dimanapun juga. Suatu survei yang diselenggarakan Asosiasi Penyelenggara Jasa Internet Indonesia (APJII) mengatakan kalau jumlah pengguna internet di Indonesia tahun 2012 menggapai 63 juta orang ataupun 24,23 persen dari total populasi negeri ini. Tahun depan, angka itu diprediksi naik dekat 30 persen jadi 82 juta pengguna serta terus berkembang jadi 107 juta pada 2014 serta 139 juta ataupun 50 persen total populasi pada 2015. juta orang. Perihal ini pula berakibat pada komunikasi politik dengan media internet, ataupun kerap diucap dengan cyber politic. Cyber politic di Indonesia hadapi pertumbuhan sebagian tahun terakhir. Banyaknya fasilitas yang menunjang pertumbuhan cyber politic semacam terdapatnya facebook, Twitter, mailing list, youtobe, serta lain-lain.Kata Kunci: Cyberpolitik, Internet 


Author(s):  
Yonghee PARK ◽  
Junghoe CHOI ◽  
Jisuk HONG ◽  
Sanghoon LEE ◽  
Moonhyun YOO ◽  
...  
Keyword(s):  
Hot Spot ◽  

Sign in / Sign up

Export Citation Format

Share Document