Accurate Systematic Hot-Spot Scoring Method and Score-Based Fixing Guidance Generation

2009 ◽  
Vol E92.A (12) ◽  
pp. 3082-3085
Author(s):  
Yonghee PARK ◽  
Junghoe CHOI ◽  
Jisuk HONG ◽  
Sanghoon LEE ◽  
Moonhyun YOO ◽  
...  
Keyword(s):  
Hot Spot ◽  
Scoring Method

Correlation of manual semi-quantitative and automated quantitative Ki-67 proliferative index with OncotypeDXTM recurrence score in invasive breast carcinoma

2021 ◽  
pp. 1-11
Author(s):  
Brian S. Finkelman ◽  
Amanda Meindl ◽  
Carissa LaBoy ◽  
Brannan Griffin ◽  
Suguna Narayan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Hot Spot ◽  
Recurrence Score ◽  
Invasive Breast Carcinoma ◽  
Chemotherapy Response ◽  
Scoring Method ◽  
Cancer Proliferation ◽  
Ki 67 ◽  
Breast Cancer Chemotherapy

BACKGROUND: Ki-67 immunohistochemistry (IHC) staining is a widely used cancer proliferation assay; however, its limitations could be improved with automated scoring. The OncotypeDXTM Recurrence Score (ORS), which primarily evaluates cancer proliferation genes, is a prognostic indicator for breast cancer chemotherapy response; however, it is more expensive and slower than Ki-67. OBJECTIVE: To compare manual Ki-67 (mKi-67) with automated Ki-67 (aKi-67) algorithm results based on manually selected Ki-67 “hot spots” in breast cancer, and correlate both with ORS. METHODS: 105 invasive breast carcinoma cases from 100 patients at our institution (2011–2013) with available ORS were evaluated. Concordance was assessed via Cohen’s Kappa (κ). RESULTS: 57/105 cases showed agreement between mKi-67 and aKi-67 (κ 0.31, 95% CI 0.18–0.45), with 41 cases overestimated by aKi-67. Concordance was higher when estimated on the same image (κ 0.53, 95% CI 0.37–0.69). Concordance between mKi-67 score and ORS was fair (κ 0.27, 95% CI 0.11–0.42), and concordance between aKi-67 and ORS was poor (κ 0.10, 95% CI −0.03–0.23). CONCLUSIONS: These results highlight the limits of Ki-67 algorithms that use manual “hot spot” selection. Due to suboptimal concordance, Ki-67 is likely most useful as a complement to, rather than a surrogate for ORS, regardless of scoring method.

The Relation Between Linguistic Awareness Skills and Spelling in Adults: A Comparison Among Scoring Procedures

2020 ◽  
Vol 63 (4) ◽  
pp. 1240-1253
Author(s):  
Victoria S. Henbest ◽  
Lisa Fitton ◽  
Krystal L. Werfel ◽  
Kenn Apel
Keyword(s):  
Phonemic Awareness ◽  
Concurrent Validity ◽  
Word Reading ◽  
Continuous Measure ◽  
Scoring Methods ◽  
Syntactic Awareness ◽  
Scoring Method ◽  
Spelling Performance ◽  
Linguistic Awareness ◽  
Average Readers

Purpose Spelling is a skill that relies on an individual's linguistic awareness, the ability to overtly manipulate language. The ability to accurately spell is important for academic and career success into adulthood. The spelling skills of adults have received some attention in the literature, but there is limited information regarding which approach for analyzing adults' spelling is optimal for guiding instruction or intervention for those who struggle. Thus, we aimed to examine the concurrent validity of four different scoring methods for measuring adults' spellings (a dichotomous scoring method and three continuous methods) and to determine whether adults' linguistic awareness skills differentially predict spelling outcomes based on the scoring method employed. Method Sixty undergraduate college students who were determined to be average readers as measured by a word reading and contextual word reading task were administered a spelling task as well as morphological, orthographic, phonemic, and syntactic awareness tasks. Results All four scoring methods were highly correlated suggesting high concurrent validity among the measures. Two linguistic awareness skills, morphological awareness and syntactic awareness, predicted spelling performance on both the dichotomous and continuous scoring methods. Contrastively, phonemic awareness and orthographic awareness predicted spelling performance only when spelling was scored using a continuous measure error analysis. Conclusions The results of this study confirm that multiple linguistic awareness skills are important for spelling in adults who are average readers. The results also highlight the need for using continuous measures of spelling when planning intervention or instruction, particularly in the areas of orthographic and phonemic awareness.

Using Principal Component Scores to Enhance the Validity and Reliability of Big Five Personality Measures

2017 ◽  
Vol 38 (2) ◽  
pp. 83-93
Author(s):  
Jeffrey M. Cucina ◽  
Nicholas L. Vasilopoulos ◽  
Arwen H. DeCostanza
Keyword(s):  
Big Five ◽  
Discriminant Validity ◽  
Reliability And Validity ◽  
Principal Component ◽  
Big Five Personality ◽  
Validity And Reliability ◽  
Scoring Method ◽  
Five Factors ◽  
Big Five Factors ◽  
Component Scores

Abstract. Varimax rotated principal component scores (VRPCS) have previously been offered as a possible solution to the non-orthogonality of scores for the Big Five factors. However, few researchers have examined the reliability and validity of VRPCS. To address this gap, we use a lab study and a field study to investigate whether using VRPCS increase orthogonality, reliability, and criterion-related validity. Compared to the traditional unit-weighting scoring method, the use of VRPCS enhanced the reliability and discriminant validity of the Big Five factors, although there was little improvement in criterion-related validity. Results are discussed in terms of the benefit of using VRPCS instead of traditional unit-weighted sum scores.

Confound It!

2019 ◽  
Vol 35 (6) ◽  
pp. 855-867 ◽  
Author(s):  
John T. Kulas ◽  
Rachael Klahr ◽  
Lindsey Knights
Keyword(s):  
Social Desirability ◽  
Response Pattern ◽  
Experimental Manipulation ◽  
Scoring Method ◽  
Method Effect ◽  
Coding Method ◽  
The Social ◽  
Current Article ◽  
Method Factors ◽  
Psychological Inventory

Abstract. Many investigators have noted “reverse-coding” method factors when exploring response pattern structure with psychological inventory data. The current article probes for the existence of a confound in these investigations, whereby an item’s level of saturation with socially desirable content tends to covary with the item’s substantive scale keying. We first investigate its existence, demonstrating that 15 of 16 measures that have been previously implicated as exhibiting a reverse-scoring method effect can also be reasonably characterized as exhibiting a scoring key/social desirability confound. A second set of analyses targets the extent to which the confounding variable may confuse interpretation of factor analytic results and documents strong social desirability associations. The results suggest that assessment developers perhaps consider the social desirability scale value of indicators when constructing scale aggregates (and possibly scales when investigating inter-construct associations). Future investigations would ideally disentangle the confound via experimental manipulation.

Mutation Spectrum in Patients with Wiskott-Aldrich Syndrome and X-linked Thrombocytopenia: Identification of Twelve Different Mutations in the WASP Gene

1996 ◽  
Vol 75 (04) ◽  
pp. 546-550 ◽  
Author(s):  
Marianne Schwartz ◽  
Albert Békássy ◽  
Mikael Donnér ◽  
Thomas Hertel ◽  
Stefan Hreidarson ◽  
...  
Keyword(s):  
Base Pair ◽  
Hot Spot ◽  
Missense Mutations ◽  
Nucleotide Substitutions ◽  
Exon 2 ◽  
Wiskott Aldrich Syndrome ◽  
Base Pair Deletion ◽  
Reliable Diagnosis ◽  
Wasp Gene ◽  
Detection Of Mutations

SummaryTwelve different mutations in the WASP gene were found in twelve unrelated families with Wiskott-Aldrich syndrome (WAS) or X-linked thrombocytopenia (XLT). Four frameshift, one splice, one nonsense mutation, and one 18-base-pair deletion were detected in seven patients with WAS. Only missense mutations were found in five patients diagnosed as having XLT. One of the nucleotide substitutions in exon 2 (codon 86) results in an Arg to Cys replacement. Two other nucleotide substitutions in this codon, R86L and R86H, have been reported previously, both giving rise to typical WAS symptoms, indicating a mutational hot spot in this codon. The finding of mutations in the WASP gene in both WAS and XLT gives further evidence of these syndromes being allelic. The relatively small size of the WASP gene facilitates the detection of mutations and a reliable diagnosis of both carriers and affected fetuses in families with WAS or XLT.

Challenges to immigrant associations and NGOs in contemporary Greece

2013 ◽  
Vol 10 (3) ◽  
pp. 342-358 ◽  
Author(s):  
Apostolos G. Papadopoulos ◽  
Christos Chalkias ◽  
Loukia-Maria Fratsea
Keyword(s):  
Civil Society ◽  
Economic Crisis ◽  
Hot Spot ◽  
Geographical Range ◽  
Legal Form ◽  
Social Actors ◽  
Governmental Organizations ◽  
Non Governmental Organizations ◽  
Migrant Integration ◽  
Concentration Patterns

The paper explores the challenges faced today, in a context of severe economic crisis, by immigrant associations (ΙΜΑs) and Non-Governmental Organizations (NGOs) in Greece. The data analysed here was collected between October 2009 and February 2010 and incorporates references to all recorded migration-related social actors operating in Greece. The paper takes into account such indicators as legal form, objectives, financial capacity and geographical range of activity, concluding with a typology of civil society actors dealing with migration issues. This study aims at informing the migration policymaking and migrant integration processes. By a spatial hot-spot clustering of IMAs and NGOs, we also illustrate the concentration patterns of civil society actors in Greece.

COMPARISION OF DENTAL SCORING SYSTEM WITH RADIOGRAPHIC SKELETAL SYSTEM IN AGE ESTIMATION

JKCD ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 9-11
Author(s):  
Sadaf Ambreen
Keyword(s):  
Age Estimation ◽  
Scoring System ◽  
Skeletal Age ◽  
Chronological Age ◽  
Age Group ◽  
Dental Age ◽  
Scoring Method ◽  
Cross Sectional ◽  
Study Results ◽  
Male Subjects

Objectives: To compare Demirjian Dental scoring method with Greulich-Pyle (GP) Skeletal method of age estimation in pubertal children. Materials and Methods: Sample of the study included 267 male healthy subjects of 11-16 years of age group.. Demirjian Scoring system was utilized to evaluate the orthopantomograms to assess their Dental age and the Hand-Wrist radiographs were analyzed to calculate the skeletal age by utilizing GP atlas. Chronological age was obtained from the date of birth of the subject .Both methods were compared with one another and with the chronological age. It was a cross-sectional study and only healthy male subjects without any clinical abnormalities were included in the study. Results: A total of 267 male subjects of 11-16 years of age group were assessed by Demirjian and Greulich Pyle Methods. Both were compared with Chronological Age. Data obtained was statistically analyzed and the Student “t” test was applied in the study population. The mean difference between Chronolgical age and dental age was 0.69years and that of chronological age and skeletal age was 0.87 years. It was observed from dental age assessment that it does not differ much from the skeletal age. Conclusion: It was concluded that Demirjian method of Age Estimation is more precise than Greulich Pyle method of Age Estimation. Furthermore both methods can be used selectively in Medicolegal cases to access bone age which can be easily correlated to chronological age.

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