TriPleX™ platform technology for photonic integration: Applications from UV through NIR to IR

Author(s):  
A. Leinse ◽  
R. G. Heideman ◽  
E. J. Klein ◽  
R. Dekker ◽  
C. G. H. Roeloffzen ◽  
...  
Small ◽  
2021 ◽  
pp. 2103025
Author(s):  
Roy Meel ◽  
Sam Chen ◽  
Josh Zaifman ◽  
Jayesh A. Kulkarni ◽  
Xu Ran S. Zhang ◽  
...  

Processes ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 874
Author(s):  
Stefan Kittler ◽  
Mihail Besleaga ◽  
Julian Ebner ◽  
Oliver Spadiut

In the past 30 years, highly specific drugs, known as antibodies, have conquered the biopharmaceutical market. In addition to monoclonal antibodies (mAbs), antibody fragments are successfully applied. However, recombinant production faces challenges. Process analytical tools for monitoring and controlling production processes are scarce and time-intensive. In the downstream process (DSP), affinity ligands are established as the primary and most important step, while the application of other methods is challenging. The use of these affinity ligands as monitoring tools would enable a platform technology to monitor process steps in the USP and DSP. In this review, we highlight the current applications of affinity ligands (proteins A, G, and L) and discuss further applications as process analytical tools.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lars Liebermeister ◽  
Simon Nellen ◽  
Robert B. Kohlhaas ◽  
Sebastian Lauck ◽  
Milan Deumer ◽  
...  

AbstractBroadband terahertz spectroscopy enables many promising applications in science and industry alike. However, the complexity of existing terahertz systems has as yet prevented the breakthrough of this technology. In particular, established terahertz time-domain spectroscopy (TDS) schemes rely on complex femtosecond lasers and optical delay lines. Here, we present a method for optoelectronic, frequency-modulated continuous-wave (FMCW) terahertz sensing, which is a powerful tool for broadband spectroscopy and industrial non-destructive testing. In our method, a frequency-swept optical beat signal generates the terahertz field, which is then coherently detected by photomixing, employing a time-delayed copy of the same beat signal. Consequently, the receiver current is inherently phase-modulated without additional modulator. Owing to this technique, our broadband terahertz spectrometer performs (200 Hz measurement rate, or 4 THz bandwidth and 117 dB peak dynamic range with averaging) comparably to state-of-the-art terahertz-TDS systems, yet with significantly reduced complexity. Thickness measurements of multilayer dielectric samples with layer-thicknesses down to 23 µm show its potential for real-world applications. Within only 0.2 s measurement time, an uncertainty of less than 2 % is achieved, the highest accuracy reported with continuous-wave terahertz spectroscopy. Hence, the optoelectronic FMCW approach paves the way towards broadband and compact terahertz spectrometers that combine fiber optics and photonic integration technologies.


2021 ◽  
Vol 490 ◽  
pp. 229527
Author(s):  
Min Wang ◽  
Wentao Yao ◽  
Peichao Zou ◽  
Shengyu Hu ◽  
Haojie Zhu ◽  
...  

2013 ◽  
Vol 44 (1) ◽  
pp. 828-831
Author(s):  
Masafumi Ide ◽  
Kaoru Yoda ◽  
Shinpei Fukaya ◽  
Takeo Komiyama ◽  
Yuji Ikeda ◽  
...  

2009 ◽  
Vol 15 (3) ◽  
pp. 482-487 ◽  
Author(s):  
D.C. Byrne ◽  
J.P. Engelstaedter ◽  
Wei-Hua Guo ◽  
Qiao Yin Lu ◽  
B. Corbett ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document