Reactive Species Transport To Water Micro-Droplets In Atmospheric Pressure Rf Glow Discharges

Plasma-activated medium (PAM) has been produced by exposing a liquid media to Argon plasma jet. The jet plasma exposure to liquid media has produced reactive Oxygen species (ROS) in liquid phase. This study aims to determine the number of reactive species in plasma-activated medium. An atmospheric pressure plasma jet (APPJ) was generated with a dielectric barrier discharge (DBD) column by AC high voltage. Some parameters varied including exposure time; i.e. 5, 10, 15, 20, 25, and 30 min; and the distance between reactor and active media; i.e. 1, 2 and 3 cm. Some analysis conducted including variation of exposure times, the distances of reactor to PAM which affect produced concentration, and the reactive species composition in plasma-activated medium. In addition, temperature characteristics, pH levels, dissolved ozone and dissolved hydrogen peroxide concentrations were also observed in this study. The results showed that increased exposure time resulted in decreased pH, increased temperature and increased concentrations of ozone and hydrogen peroxide. The maximum reactive species composition was obtained at the distance between reactor and plasma-activated medium of 2 cm. Maximum reactive species composition obtained in this study has temperature of 29-30 Celsius degrees; pH 3.5; dissolved ozone 2.97 ppm; and Hydrogen Peroxide 215 ppm.

Download Full-text

Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment

Applied Sciences ◽

10.3390/app10196898 ◽

2020 ◽

Vol 10 (19) ◽

pp. 6898

Author(s):

Lars Boeckmann ◽

Mirijam Schäfer ◽

Thoralf Bernhardt ◽

Marie Luise Semmler ◽

Ole Jung ◽

...

Keyword(s):

Wound Healing ◽

Cancer Therapy ◽

Cancer Treatment ◽

Atmospheric Pressure ◽

Atmospheric Pressure Plasma ◽

Reactive Species ◽

Therapeutic Effects ◽

Preclinical Research ◽

Pressure Plasma ◽

Cold Atmospheric Pressure Plasma

Plasma medicine is gaining increasing attention and is moving from basic research into clinical practice. While areas of application are diverse, much research has been conducted assessing the use of cold atmospheric pressure plasma (CAP) in wound healing and cancer treatment—two applications with entirely different goals. In wound healing, a tissue-stimulating effect is intended, whereas cancer therapy aims at killing malignant cells. In this review, we provide an overview of the latest clinical and some preclinical research on the efficacy of CAP in wound healing and cancer therapy. Furthermore, we discuss the current understanding of molecular signaling mechanisms triggered by CAP that grant CAP its antiseptic and tissue regenerating or anti-proliferative and cell death-inducing properties. For the efficacy of CAP in wound healing, already substantial evidence from clinical studies is available, while evidence for therapeutic effects of CAP in oncology is mainly from in vitro and in vivo animal studies. Efforts to elucidate the mode of action of CAP suggest that different components, such as ultraviolet (UV) radiation, electromagnetic fields, and reactive species, may act synergistically, with reactive species being regarded as the major effector by modulating complex and concentration-dependent redox signaling pathways.

Download Full-text