scholarly journals Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment

2020 ◽  
Vol 10 (19) ◽  
pp. 6898
Author(s):  
Lars Boeckmann ◽  
Mirijam Schäfer ◽  
Thoralf Bernhardt ◽  
Marie Luise Semmler ◽  
Ole Jung ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Reactive Species ◽  
Therapeutic Effects ◽  
Preclinical Research ◽  
Pressure Plasma ◽  
Cold Atmospheric Pressure Plasma

Plasma medicine is gaining increasing attention and is moving from basic research into clinical practice. While areas of application are diverse, much research has been conducted assessing the use of cold atmospheric pressure plasma (CAP) in wound healing and cancer treatment—two applications with entirely different goals. In wound healing, a tissue-stimulating effect is intended, whereas cancer therapy aims at killing malignant cells. In this review, we provide an overview of the latest clinical and some preclinical research on the efficacy of CAP in wound healing and cancer therapy. Furthermore, we discuss the current understanding of molecular signaling mechanisms triggered by CAP that grant CAP its antiseptic and tissue regenerating or anti-proliferative and cell death-inducing properties. For the efficacy of CAP in wound healing, already substantial evidence from clinical studies is available, while evidence for therapeutic effects of CAP in oncology is mainly from in vitro and in vivo animal studies. Efforts to elucidate the mode of action of CAP suggest that different components, such as ultraviolet (UV) radiation, electromagnetic fields, and reactive species, may act synergistically, with reactive species being regarded as the major effector by modulating complex and concentration-dependent redox signaling pathways.

scholarly journals Inactivation by helium cold atmospheric pressure plasma for Escherichia coli and Staphylococcus aureus

2019 ◽  
Vol 14 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Khaled Lotfy ◽  
Sayed Mohammed Khalil ◽  
Hany Abd El-Raheem
Keyword(s):  
Flow Rate ◽  
Atmospheric Pressure ◽  
Plasma Temperature ◽  
Wavelength Region ◽  
Atmospheric Pressure Plasma ◽  
Optical Emission ◽  
Reactive Species ◽  
Pressure Plasma ◽  
Cold Atmospheric Pressure Plasma ◽  
The Impact

AbstractA helium cold atmospheric pressure plasma jet (HCAPPJ) driven by a commercial neon power supply was designed and utilized for inactivation bacteria. The generated reactive spices by HCAPPJ were investigated by optical emission spectroscopy. The reactive species of OH, OI, OI, N21+, N21+ and He were identified in the UV–Vis wavelength region. The reactive species was not detected between 200 nm and 300 nm, as the flow rate of helium gas increased that led to the plasma temperature reducing to a value near to the room temperature. In this work, we studied the impact of HCAPPJ on Gram-positive and Gram-negative bacteria. The survival amounts of the two types of bacteria were decreased vastly when the rate flow rate was equal to 10 L/min.

593-P: Cold Atmospheric Pressure Plasma for Accelerated Wound Healing in Diabetic Foot: The Prospective, Randomized, Placebo-Controlled KPW-Trial

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 593-P
Author(s):  
BERND STRATMANN ◽  
TANIA-CRISTINA COSTEA ◽  
CATHARINA NOLTE ◽  
JONAS HILLER ◽  
JÖRN SCHMIDT ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Pressure Plasma ◽  
Cold Atmospheric Pressure Plasma

scholarly journals Applications of Cold Atmospheric Pressure Plasma in Dentistry

2021 ◽  
Vol 11 (5) ◽  
pp. 1975
Author(s):  
Aline C. Borges ◽  
Konstantin G. Kostov ◽  
Rodrigo S. Pessoa ◽  
Geraldo M.A. de Abreu ◽  
Gabriela de M.G. Lima ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Biological Effects ◽  
Atmospheric Pressure Plasma ◽  
Reactive Species ◽  
Electrically Conducting ◽  
Pressure Plasma ◽  
Cold Plasmas ◽  
Cold Atmospheric Pressure Plasma ◽  
Ultraviolet Photons ◽  
Oral Oncology

Plasma is an electrically conducting medium that responds to electric and magnetic fields. It consists of large quantities of highly reactive species, such as ions, energetic electrons, exited atoms and molecules, ultraviolet photons, and metastable and active radicals. Non-thermal or cold plasmas are partially ionized gases whose electron temperatures usually exceed several tens of thousand degrees K, while the ions and neutrals have much lower temperatures. Due to the presence of reactive species at low temperature, the biological effects of non-thermal plasmas have been studied for application in the medical area with promising results. This review outlines the application of cold atmospheric pressure plasma (CAPP) in dentistry for the control of several pathogenic microorganisms, induction of anti-inflammatory, tissue repair effects and apoptosis of cancer cells, with low toxicity to healthy cells. Therefore, CAPP has potential to be applied in many areas of dentistry such as cariology, periodontology, endodontics and oral oncology.

scholarly journals Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 269 ◽  
Author(s):  
Marie Luise Semmler ◽  
Sander Bekeschus ◽  
Mirijam Schäfer ◽  
Thoralf Bernhardt ◽  
Tobias Fischer ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Atmospheric Pressure ◽  
Molecular Mechanisms ◽  
Cell Cancer ◽  
Atmospheric Pressure Plasma ◽  
Innovative Technology ◽  
Pilot Studies ◽  
Pressure Plasma ◽  
Cold Atmospheric Pressure Plasma ◽  
Underlying Mechanisms

Recently, the potential use of cold atmospheric pressure plasma (CAP) in cancer treatment has gained increasing interest. Especially the enhanced selective killing of tumor cells compared to normal cells has prompted researchers to elucidate the molecular mechanisms for the efficacy of CAP in cancer treatment. This review summarizes the current understanding of how CAP triggers intracellular pathways that induce growth inhibition or cell death. We discuss what factors may contribute to the potential selectivity of CAP towards cancer cells compared to their non-malignant counterparts. Furthermore, the potential of CAP to trigger an immune response is briefly discussed. Finally, this overview demonstrates how these concepts bear first fruits in clinical applications applying CAP treatment in head and neck squamous cell cancer as well as actinic keratosis. Although significant progress towards understanding the underlying mechanisms regarding the efficacy of CAP in cancer treatment has been made, much still needs to be done with respect to different treatment conditions and comparison of malignant and non-malignant cells of the same cell type and same donor. Furthermore, clinical pilot studies and the assessment of systemic effects will be of tremendous importance towards bringing this innovative technology into clinical practice.

scholarly journals Effects of O2 Addition on the Discharge Parameters and Production of Reactive Species of a Transferred Atmospheric Pressure Plasma Jet

2021 ◽  
Vol 11 (14) ◽  
pp. 6311
Author(s):  
Fellype Nascimento ◽  
Kleber Petroski ◽  
Konstantin Kostov
Keyword(s):  
Atmospheric Pressure ◽  
Light Emission ◽  
Noble Gas ◽  
Atmospheric Pressure Plasma ◽  
Plasma Jet ◽  
Reactive Species ◽  
Plasma Jets ◽  
Therapeutic Effects ◽  
Plastic Tube ◽  
Pressure Plasma

The therapeutic effects of atmospheric pressure plasma jets (APPJs) have been associated with the presence of reactive species, mainly the reactive oxygen and nitrogen ones, generated in this kind of plasmas. Due to that, many studies attempting to enhance the production of reactive species in APPJs have been performed. The employment of gas admixtures, usually mixing a noble gas with oxygen (O2) or water vapor, is one of the most common methods to achieve such goal. This work presents a study of how the addition of small amounts of O2 affects the electrical parameters and the production of reactive species in a transferred APPJ produced at the tip of a long and flexible plastic tube. The study was carried out employing helium (He) as the working gas and applying a high voltage (HV) in the form of amplitude-modulated sine waveform (burst mode). With this configuration it was possible to verify that the O2 addition reduces the discharge power and effective current, as a result of late ignition and shorter discharge duration. It was also found that the addition of O2 to a certain content in the gas admixture makes the light emission from oxygen atoms increase, indicating an increment in oxygen related reactive species in the plasma jet. However, at the same time the light emitted from hydroxyl (OH) and nitric oxide (NO) exhibits the opposite behavior, i.e., decrease, indicating a reduction of such species in the APPJ. For these reasons, the addition of O2 to the working gas seems to be useful for increasing the effectiveness of the plasma treatment only when the target modification effect is directly dependent on the content of atomic oxygen.

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