A study on enhanced hyperthermia treatment for liver cancer using magnetic nanoparticles

2014 ◽  
Author(s):  
Maryory Urdaneta ◽  
Parveen Wahid
Keyword(s):  
Magnetic Nanoparticles ◽  
Liver Cancer ◽  
Hyperthermia Treatment

scholarly journals Nanoparticles in enhancing microwave imaging and microwave Hyperthermia effect for liver cancer treatment

2021 ◽  
Vol 60 (1) ◽  
pp. 223-236
Author(s):  
Walaa Maamoun ◽  
Mohamed I. Badawi ◽  
Ayman A Aly ◽  
Y. Khedr
Keyword(s):  
Silver Nanoparticles ◽  
Liver Cancer ◽  
Cancer Treatment ◽  
Electromagnetic Waves ◽  
Microwave Imaging ◽  
Healthy Tissue ◽  
Cancer Tissue ◽  
Hyperthermia Treatment ◽  
Hyperthermia Therapy ◽  
Surrounding Healthy Tissue

Abstract Hyperthermia therapy is a promising therapy for liver cancer treatment that utilizes external electromagnetic waves to heat the tumor zone to preferentially kill or minimize cancer cells. Nevertheless, it’s a challenge to realize localized heating of the cancer tissue without harming the surrounding healthy tissue. This research proposes to utilize nanoparticles as microwave absorbers to enhance microwave imaging and achieve localized hyperthermia therapy. A realistic 3D abdomen model has been segmented using 3D Slicer segmentation software, and then the obtained segmented CAD model exported to Computer Simulation Technology (CST STUDIO) for applying the Finite Element Modeling (FEM). Next investigating both imaging and treatment capability. Finally, the specific absorption rate (SAR) and temperature distribution were computed without nanoparticles and with different types of nanoparticles such as gold (GNPs) and silver nanoparticles at frequency 915 MHz. By comparing the achived results, it was seen that Silver nanoparticles can make a great enhancement in raising the temperature. However, this result was unsatisfactory but, after adding gold nanoparticles the temperature exceed 42°C, at frequency 915 MHz which is achieving the hyperthermia treatment without harming the nearby healthy tissue, GNPs also can achieve a great enhancement in SAR result

Recent advancements in brain tumor targeting using magnetic nanoparticles

2020 ◽  
Vol 11 (2) ◽  
pp. 97-112 ◽  
Author(s):  
Himanshu Gandhi ◽  
Abhishek Kumar Sharma ◽  
Shikha Mahant ◽  
Deepak N Kapoor
Keyword(s):  
Gene Therapy ◽  
Brain Tumor ◽  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Tumor Targeting ◽  
Chemotherapeutic Agents ◽  
Diagnostic Systems ◽  
Hyperthermia Treatment ◽  
Recent Developments ◽  
The Brain

Transport of drugs through the blood–brain barrier to the brain and the toxic effects of drugs on the healthy cells can limit the effectiveness of chemotherapeutic agents. In recent years, magnetic nanoparticles (MNPs) have received much attention as targeted therapeutic and diagnostic systems due to their simplicity, ease of preparation and ability to tailor their properties such as their composition, size, surface morphology, etc. for biomedical applications. MNPs are utilized in drug delivery, radio therapeutics, hyperthermia treatment, gene therapy, biotherapeutics and diagnostic imaging. The present review will address the challenges in brain tumor targeting and discuss the application and recent developments in brain tumor targeting using MNPs.

scholarly journals The Intracellular Number of Magnetic Nanoparticles Modulates the Apoptotic Death Pathway after Magnetic Hyperthermia Treatment

2020 ◽  
Vol 12 (39) ◽  
pp. 43474-43487
Author(s):  
Lilianne Beola ◽  
Laura Asín ◽  
Catarina Roma-Rodrigues ◽  
Yilian Fernández-Afonso ◽  
Raluca M. Fratila ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Hyperthermia Treatment ◽  
Apoptotic Death

scholarly journals Biomedical Applications of Biomaterials Functionalized with Magnetic Nanoparticles

2020 ◽  
Author(s):  
Matteo Bruno Lodi ◽  
Alessandro Fanti
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Heat Dissipation ◽  
Hyperthermia Treatment ◽  
Prosthetic Implants ◽  
Magnetic Carriers ◽  
Magnetic Drug Delivery ◽  
Influence Parameter ◽  
Nonlinear Nature

The combination of magnetic nanoparticles and a biocompatible material leads to the manufacturing of a multifunctional and remotely controlled platform useful for diverse biomedical issues. If a static magnetic field is applied, a magnetic scaffold behaves like an attraction platform for magnetic carriers of growth factors, thus being a potential tool to enhance magnetic drug delivery in regenerative medicine. To translate in practice this potential application, a careful and critical description of the physics and the influence parameter is required. This chapter covers the mathematical modeling of the process and assesses the problem of establishing the influence of the drug delivery system on tissue regeneration. On the other hand, if a time-varying magnetic field is applied, the magnetic nanoparticles would dissipate heat, which can be exploited to perform local hyperthermia treatment on residual cancer cells in the bone tissue. To perform the treatment planning, it is necessary to account for the modeling of the intrinsic nonlinear nature of the heat dissipation dynamic in magnetic prosthetic implants. In this work, numeric experiments to investigate the physiopathological features of the biological system, linked to the properties of the nanocomposite magnetic material, to assess its effectiveness as therapeutic agents are presented.

scholarly journals Modeling of Optimal Targeted Therapies Using Drug-Loaded Magnetic Nanoparticles for Liver Cancer

2016 ◽  
Vol 15 (3) ◽  
pp. 265-274 ◽  
Author(s):  
Lyes Mellal ◽  
David Folio ◽  
Karim Belharet ◽  
Antoine Ferreira
Keyword(s):  
Magnetic Nanoparticles ◽  
Liver Cancer ◽  
Targeted Therapies

Development of a dual-functional Pt–Fe-HAP magnetic nanoparticles application for chemo-hyperthermia treatment of cancer

2014 ◽  
Vol 40 (4) ◽  
pp. 5117-5127 ◽  
Author(s):  
Ching-Li Tseng ◽  
Kuo-Chi Chang ◽  
Mei-Chun Yeh ◽  
Kai-Chiang Yang ◽  
Tzu-Piao Tang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Hyperthermia Treatment ◽  
Dual Functional

scholarly journals Influence of Magnetic Scaffold Loading Patterns on their Hyperthermic Potential against Bone Tumors

2021 ◽  
Author(s):  
Matteo Bruno Lodi ◽  
Nicola Curreli ◽  
Sonia Zappia ◽  
Luca Pilia ◽  
Maria Francesca Casula ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Magnetic Nanoparticles ◽  
Magnetic Measurements ◽  
Casting Process ◽  
Hyperthermia Treatment ◽  
Morphological Alterations ◽  
Nanoparticle Distribution ◽  
Tumor Hyperthermia ◽  
Loading Patterns ◽  
Poly Caprolactone

Magnetic scaffolds have been investigated as promising tools for the interstitial hyperthermia treatment of bone cancers, to control local recurrence by enhancing radio- and chemotherapy effectiveness. The potential of magnetic scaffolds motivates the development of production strategies enabling tunability of the resulting magnetic properties. Within this framework, deposition and drop-casting of magnetic nanoparticles on suitable scaffolds offer advantages such as ease of production and high loading, although these approaches are often associated with a non-uniform final spatial distribution of nanoparticles in the biomaterial. The implications and the influences of nanoparticle distribution on the final therapeutic application have not yet been investigated thoroughly. In this work, poly-caprolactone scaffolds are magnetized by loading them with synthetic magnetic nanoparticles through a drop-casting deposition and tuned to obtain different distributions of magnetic nanoparticles in the biomaterial. The physicochemical properties of the magnetic scaffolds are analyzed. The microstructure and the morphological alterations due to the reworked drop-casting process are evaluated and correlated to static magnetic measurements. THz tomography is used as an investigation technique to derive the spatial distribution of nanoparticles. Finally, in silico multiphysics experiments are used to investigate the influence on the loading patterns on the interstitial bone tumor hyperthermia treatment.

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