scholarly journals Influence of Magnetic Scaffold Loading Patterns on their Hyperthermic Potential against Bone Tumors

2021 ◽  
Author(s):  
Matteo Bruno Lodi ◽  
Nicola Curreli ◽  
Sonia Zappia ◽  
Luca Pilia ◽  
Maria Francesca Casula ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Magnetic Nanoparticles ◽  
Magnetic Measurements ◽  
Casting Process ◽  
Hyperthermia Treatment ◽  
Morphological Alterations ◽  
Nanoparticle Distribution ◽  
Tumor Hyperthermia ◽  
Loading Patterns ◽  
Poly Caprolactone

Magnetic scaffolds have been investigated as promising tools for the interstitial hyperthermia treatment of bone cancers, to control local recurrence by enhancing radio- and chemotherapy effectiveness. The potential of magnetic scaffolds motivates the development of production strategies enabling tunability of the resulting magnetic properties. Within this framework, deposition and drop-casting of magnetic nanoparticles on suitable scaffolds offer advantages such as ease of production and high loading, although these approaches are often associated with a non-uniform final spatial distribution of nanoparticles in the biomaterial. The implications and the influences of nanoparticle distribution on the final therapeutic application have not yet been investigated thoroughly. In this work, poly-caprolactone scaffolds are magnetized by loading them with synthetic magnetic nanoparticles through a drop-casting deposition and tuned to obtain different distributions of magnetic nanoparticles in the biomaterial. The physicochemical properties of the magnetic scaffolds are analyzed. The microstructure and the morphological alterations due to the reworked drop-casting process are evaluated and correlated to static magnetic measurements. THz tomography is used as an investigation technique to derive the spatial distribution of nanoparticles. Finally, in silico multiphysics experiments are used to investigate the influence on the loading patterns on the interstitial bone tumor hyperthermia treatment.

scholarly journals Influence of Magnetic Scaffold Loading Patterns on their Hyperthermic Potential against Bone Tumors

2021 ◽  
Author(s):  
Matteo Bruno Lodi ◽  
Nicola Curreli ◽  
Sonia Zappia ◽  
Luca Pilia ◽  
Maria Francesca Casula ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Magnetic Nanoparticles ◽  
Magnetic Measurements ◽  
Casting Process ◽  
Hyperthermia Treatment ◽  
Morphological Alterations ◽  
Nanoparticle Distribution ◽  
Tumor Hyperthermia ◽  
Loading Patterns ◽  
Poly Caprolactone

Magnetic scaffolds have been investigated as promising tools for the interstitial hyperthermia treatment of bone cancers, to control local recurrence by enhancing radio- and chemotherapy effectiveness. The potential of magnetic scaffolds motivates the development of production strategies enabling tunability of the resulting magnetic properties. Within this framework, deposition and drop-casting of magnetic nanoparticles on suitable scaffolds offer advantages such as ease of production and high loading, although these approaches are often associated with a non-uniform final spatial distribution of nanoparticles in the biomaterial. The implications and the influences of nanoparticle distribution on the final therapeutic application have not yet been investigated thoroughly. In this work, poly-caprolactone scaffolds are magnetized by loading them with synthetic magnetic nanoparticles through a drop-casting deposition and tuned to obtain different distributions of magnetic nanoparticles in the biomaterial. The physicochemical properties of the magnetic scaffolds are analyzed. The microstructure and the morphological alterations due to the reworked drop-casting process are evaluated and correlated to static magnetic measurements. THz tomography is used as an investigation technique to derive the spatial distribution of nanoparticles. Finally, in silico multiphysics experiments are used to investigate the influence on the loading patterns on the interstitial bone tumor hyperthermia treatment.

scholarly journals GEOLOGICAL AND MAGNETIC SUSCEPTIBILITY MAPPING OF MOUNT GIOUCHTA (CENTRAL CRETE)

2017 ◽  
Vol 43 (1) ◽  
pp. 289 ◽  
Author(s):  
E. Kokinou ◽  
E. Kamberis ◽  
A. Sarris ◽  
I. Tzanaki
Keyword(s):  
Magnetic Susceptibility ◽  
Spatial Distribution ◽  
Stress Field ◽  
Magnetic Measurements ◽  
Strain Analysis ◽  
Geological Structure ◽  
Early Pleistocene ◽  
Middle Pleistocene ◽  
Western Slope ◽  
Strain Pattern

Giouchta Mt. is located south of Heraklion city, in Crete. It is an N-S trending morphological asymmetric ridge, with steep western slope whilst the eastern slope represents a smoother relief, composed of Mesozoic limestone and Eocene- lower Oligocene flysch sediments of the Gavrovo -Tripolis zone. The present study focuses on the geological structure of Mt. Giouchta. Field mapping and tectonic analysis is performed for this purpose. The dominant structures are contractional in nature, deformed by normal faulting related to the extensional episodes initiated in Serravallian times. The strain pattern in the area is revealed from strain analysis. It is inferred that the orientation of the stress field in the area has changed several times: the N-S, stress field which was dominant during Late Serravallian times changed to NE-SW (in Late Serravallian? - Early Tortonian) and subsequently to WNW-ESE (Early to Middle Tortonian) to become NW-SE in Late Tortonian. This orientation changed also during the Quaternary times trending from NW-SE (Early Pleistocene) to ENE-WSW (Middle Pleistocene-Holocene). In addition to the above, surface soil samples were collected in the wider area of mount Giouchta and they were analyzed in order to determine the magnetic susceptibility. GIS techniques were used for mapping the spatial distribution of the geological features and the magnetic measurements on the topographic relief of the area. Statistical analysis techniques were also applied in order to investigate the relation of faulting and magnetic susceptibility. Maps representing the spatial distribution of the above measurements were created by using appropriate interpolation algorithms.

scholarly journals Magnetic Nanoparticles of Zinc/Calcium Ferrite Decorated with Silver for Photodegradation of Dyes

Materials ◽  
2019 ◽  
Vol 12 (21) ◽  
pp. 3582 ◽  
Author(s):  
Ricardo J. C. Fernandes ◽  
Carlos A. B. Magalhães ◽  
Carlos O. Amorim ◽  
Vítor S. Amaral ◽  
Bernardo G. Almeida ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Optical Band Gap ◽  
Magnetic Measurements ◽  
Ferrite Nanoparticles ◽  
Calcium Ferrite ◽  
Size Estimation ◽  
Visible Absorption ◽  
Uv Visible ◽  
Calcium Ferrites ◽  
Reactive Red 195

Magnetic nanoparticles of zinc/calcium ferrite and decorated with silver were prepared by coprecipitation method. The obtained nanoparticles were characterized by UV/Visible absorption, XRD, TEM and SQUID. The mixed zinc/calcium ferrites exhibit an optical band gap of 1.78 eV. HR-TEM imaging showed rectangular nanoplate shapes with sizes of 10 ± 3 nm and aspect ratio mainly between 1 and 1.5. Magnetic measurements indicated a superparamagnetic behavior. XRD diffractograms allowed a size estimation of 4 nm, which was associated with the nanoplate thickness. The silver-decorated zinc/calcium ferrite nanoparticles were successfully employed in the photodegradation of a model dye (Rhodamine B) and industrial textile dyes (CI Reactive Red 195, CI Reactive Blue 250 and CI Reactive Yellow 145). The nanosystems developed exhibited promising results for industrial application in effluent photoremediation using visible light, with the possibility of magnetic recovery.

Recent advancements in brain tumor targeting using magnetic nanoparticles

2020 ◽  
Vol 11 (2) ◽  
pp. 97-112 ◽  
Author(s):  
Himanshu Gandhi ◽  
Abhishek Kumar Sharma ◽  
Shikha Mahant ◽  
Deepak N Kapoor
Keyword(s):  
Gene Therapy ◽  
Brain Tumor ◽  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Tumor Targeting ◽  
Chemotherapeutic Agents ◽  
Diagnostic Systems ◽  
Hyperthermia Treatment ◽  
Recent Developments ◽  
The Brain

Transport of drugs through the blood–brain barrier to the brain and the toxic effects of drugs on the healthy cells can limit the effectiveness of chemotherapeutic agents. In recent years, magnetic nanoparticles (MNPs) have received much attention as targeted therapeutic and diagnostic systems due to their simplicity, ease of preparation and ability to tailor their properties such as their composition, size, surface morphology, etc. for biomedical applications. MNPs are utilized in drug delivery, radio therapeutics, hyperthermia treatment, gene therapy, biotherapeutics and diagnostic imaging. The present review will address the challenges in brain tumor targeting and discuss the application and recent developments in brain tumor targeting using MNPs.

scholarly journals The Intracellular Number of Magnetic Nanoparticles Modulates the Apoptotic Death Pathway after Magnetic Hyperthermia Treatment

2020 ◽  
Vol 12 (39) ◽  
pp. 43474-43487
Author(s):  
Lilianne Beola ◽  
Laura Asín ◽  
Catarina Roma-Rodrigues ◽  
Yilian Fernández-Afonso ◽  
Raluca M. Fratila ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Hyperthermia Treatment ◽  
Apoptotic Death

scholarly journals Biomedical Applications of Biomaterials Functionalized with Magnetic Nanoparticles

2020 ◽  
Author(s):  
Matteo Bruno Lodi ◽  
Alessandro Fanti
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Heat Dissipation ◽  
Hyperthermia Treatment ◽  
Prosthetic Implants ◽  
Magnetic Carriers ◽  
Magnetic Drug Delivery ◽  
Influence Parameter ◽  
Nonlinear Nature

The combination of magnetic nanoparticles and a biocompatible material leads to the manufacturing of a multifunctional and remotely controlled platform useful for diverse biomedical issues. If a static magnetic field is applied, a magnetic scaffold behaves like an attraction platform for magnetic carriers of growth factors, thus being a potential tool to enhance magnetic drug delivery in regenerative medicine. To translate in practice this potential application, a careful and critical description of the physics and the influence parameter is required. This chapter covers the mathematical modeling of the process and assesses the problem of establishing the influence of the drug delivery system on tissue regeneration. On the other hand, if a time-varying magnetic field is applied, the magnetic nanoparticles would dissipate heat, which can be exploited to perform local hyperthermia treatment on residual cancer cells in the bone tissue. To perform the treatment planning, it is necessary to account for the modeling of the intrinsic nonlinear nature of the heat dissipation dynamic in magnetic prosthetic implants. In this work, numeric experiments to investigate the physiopathological features of the biological system, linked to the properties of the nanocomposite magnetic material, to assess its effectiveness as therapeutic agents are presented.

2D24 Possibility of brain tumor hyperthermia treatment using coaxial needle applicator made of SMA

2014 ◽  
Vol 2014.26 (0) ◽  
pp. 405-406
Author(s):  
Kazutoshi SHIBAFUJI ◽  
Yasuhiro SHINDO ◽  
Yuya ISEKI ◽  
Kazuo KATO ◽  
Mitsunori KUBO
Keyword(s):  
Brain Tumor ◽  
Hyperthermia Treatment ◽  
Coaxial Needle ◽  
Tumor Hyperthermia
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