Targeted Drug Delivery for Cardiovascular Disease: Modeling of Modulated Extracellular Vesicle Release Rates

2021 ◽  
Vol 20 (4) ◽  
pp. 444-454 ◽  
Author(s):  
Hamid Khoshfekr Rudsari ◽  
Mladen Veletic ◽  
Jacob Bergsland ◽  
Ilangko Balasingham
Keyword(s):  
Cardiovascular Disease ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Disease Modeling ◽  
Extracellular Vesicle ◽  
Release Rates ◽  
Vesicle Release ◽  
Targeted Drug

scholarly journals Mitochondria-Targeted Drug Delivery in Cardiovascular Disease: A Long Road to Nano-Cardio Medicine

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1122
Author(s):  
Francesca Forini ◽  
Paola Canale ◽  
Giuseppina Nicolini ◽  
Giorgio Iervasi
Keyword(s):  
Cardiovascular Disease ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Mitochondrial Permeability Transition ◽  
Therapeutic Option ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Nanoparticle Delivery ◽  
Innovative Therapies ◽  
Targeted Drug

Cardiovascular disease (CVD) represents a major threat for human health. The available preventive and treatment interventions are insufficient to revert the underlying pathological processes, which underscores the urgency of alternative approaches. Mitochondria dysfunction plays a key role in the etiopathogenesis of CVD and is regarded as an intriguing target for the development of innovative therapies. Oxidative stress, mitochondrial permeability transition pore opening, and excessive fission are major noxious pathways amenable to drug therapy. Thanks to the advancements of nanotechnology research, several mitochondria-targeted drug delivery systems (DDS) have been optimized with improved pharmacokinetic and biocompatibility, and lower toxicity and antigenicity for application in the cardiovascular field. This review summarizes the recent progress and remaining obstacles in targeting mitochondria as a novel therapeutic option for CVD. The advantages of nanoparticle delivery over un-targeted strategies are also discussed.

Various Novel Drug Delivery Systems in Treatment of Cardiovascular Diseases

2019 ◽  
Vol 7 (04) ◽  
pp. 01-04
Author(s):  
S. Gousia Begum
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Transdermal Patches ◽  
Drug Eluting ◽  
Targeted Drug ◽  
Novel Drug

Cardiovascular disease the life threatens issues in the present days, which includes other diseases like angina pectoris, atherosclerosis, and myocardial infarction. The various novel drug delivery systems like transdermal patches, liposomes, micelles, nanoparticles, microbubbles, drug-eluting balloons, and an eluting drug stents are used for targeted drug delivery and improved therapeutic efficacy and showed better patient compliance in the present days.

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