VR and Volitional Pain: Testing Immersive Interventions During a Tattoo

OBJECTIVE: This study aimed to evaluate maximum bite forces (mBF) in dominant (DS) and non-dominant sides (NDS) at certain time periods after the insertion of new complete dentures based on prior experience and gender.MATERIALS AND METHODS: A total of 88 patients, complete denture wearers (CDWs), were examined. The maximum bite force at the intercuspal position between the first molars in 3 seconds was registered and recorded with piezoelectric gnathodynamometer. The procedure was repeated 3 times in identical conditions, with relaxation intervals of 1 minute between repeats and the limiting factor was the subjective feeling of pain. Testing of parametric data was performed with One Way Repeated Measurement of ANOVA test.RESULTS: The average mBF values increased during the observational period, both on the DS and NDS, with significant difference in DS, which was greater. The analysis of one-factor variance showed that there were differences of average mBF values in DS and NDS during six consecutive measurements (mBF–DS = 11.3, p = 0.0001, and mBF-NDS = 2.26, p = 0.047). Significant changes in the masticatory force (mBF) on the DS and NDS is explained by different measurement times and with the prior experience with complete dentures, BF–DS = 11.76, p = 0.0000; mBF–NDS = 2.42, p = 0.0351; mBFe–DS = 40.48; P = 0.0000 mBFe–NDS = 39.93, p = 0.0000.CONCLUSION: mBF represents a significant discriminating variable of the level of functional adaptation of new complete denture wearers (nCDWs) about the initial measurements.

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Pain Testing in the Laboratory Mouse

Anesthesia and Analgesia in Laboratory Animals ◽

10.1016/b978-012373898-1.50027-9 ◽

2008 ◽

pp. 549-560 ◽

Cited By ~ 1

Author(s):

Dale J. Langford ◽

Jeffrey S. Mogil

Keyword(s):

Laboratory Mouse ◽

Pain Testing

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0233 Pain, Fatigue, and Altered Reactivity to a Repeated Physiological Stressor in Insomnia Patients: An Explanatory-Driven Analysis

SLEEP ◽

10.1093/sleep/zsaa056.231 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A90-A90

Author(s):

M R Goldstein ◽

J K Devine ◽

R Dang ◽

B Chatterton ◽

J Scott-Sutherland ◽

...

Keyword(s):

Cold Water ◽

Cold Pressor Test ◽

Cold Pressor ◽

Comprehensive Treatment ◽

Spontaneous Pain ◽

Science Center ◽

Female Age ◽

Complex Relationships ◽

Physiological Stressor ◽

Pain Testing

Abstract Introduction Fatigue and pain are prominent features of functional impairment in insomnia. This study aimed to better understand behavioral and physiological mechanisms of these complex relationships. Methods 22 participants with insomnia disorder (DSM-5 criteria, 18 female, age 18-49yrs) and 22 good-sleeper controls (19 female, age 18-47yrs) completed two-weeks sleep logs and actigraphy recordings prior to coming to the laboratory for overnight polysomnography and subsequent daytime testing that included questionnaires, three trials of cold pressor test (CPT), and pain testing with blood draws collected throughout. Insomnia diagnosis was determined by a board-certified sleep specialist, and exclusion criteria included psychiatric history within past 6 months, other sleep disorder, significant medical conditions, and any medications within past two weeks with significant effects on inflammation, autonomic function, or other psychotropic effects. For CPT, participants were instructed to immerse hand in ice cold water for at least one minute and rate pain intensity throughout the immersion and 3-minute recovery. Data were analyzed with linear mixed models. Results Per inclusion criteria, PSQI scores were differed between groups (insomnia: 10.2±2.7, range 7–16; control: 1.9±1.3, range 0–5; p<.001). Insomnia consistently reported higher daily fatigue ratings compared to controls (p<.001), as well as higher spontaneous pain globally and across several specific domains (p’s: .007-.03). In response to CPT, groups did not differ in their initial tolerance (i.e. immersion duration, p=.41) or intensity ratings during immersion (p=.88), however insomnia showed blunted recovery in intensity ratings (p<.01). Control participants then showed an ability to habituate to repeated CPT by increasing immersion duration, whereas insomnia slightly decreased in tolerance across trials (Group effect: p<.05). Conclusion These data indicate that habituation to and acute recovery from pain is deteriorated in chronic insomnia, which may be a key contributor to maintained pathophysiology over time and mechanism to target with comprehensive treatment. Support Merck Inc. MISP# 51971 (investigator-initiated), NIH/National Center for Research Resources UL1-RR02758 and M01-RR01032 to the Harvard Clinical and Translational Science Center.

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Sex Differences in Interleukin-6 Responses Over Time Following Laboratory Pain Testing Among Patients With Knee Osteoarthritis

Journal of Pain ◽

10.1016/j.jpain.2019.11.003 ◽

2020 ◽

Vol 21 (5-6) ◽

pp. 731-741

Author(s):

Chung Jung Mun ◽

Janelle E. Letzen ◽

Sabrina Nance ◽

Michael T. Smith ◽

Harpal S. Khanuja ◽

...

Keyword(s):

Sex Differences ◽

Knee Osteoarthritis ◽

Interleukin 6 ◽

Pain Testing ◽

Over Time

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A Hyperpigmented Reticular Rash in a Patient on Peritoneal Dialysis

Peritoneal Dialysis International ◽

10.3747/pdi.2016.00042 ◽

2016 ◽

Vol 36 (6) ◽

pp. 699-700 ◽

Cited By ~ 2

Author(s):

Andrew M. South ◽

Milene K. Crispin ◽

Ann L. Marqueling ◽

Scott M. Sutherland

Keyword(s):

Peritoneal Dialysis ◽

Insertion Site ◽

Chronically Ill ◽

Cutaneous Eruption ◽

Erythema Ab Igne ◽

Low Levels ◽

Stage Renal Disease ◽

End Stage ◽

Pain Testing ◽

Chronically Ill Patients

Chronically ill patients often develop uncommon exam findings. A 16-year-old female with end-stage renal disease secondary to immune complex-mediated glomerulonephritis on peritoneal dialysis (PD) developed a pruritic, hyperpigmented reticular rash on her abdomen, sparing the PD catheter insertion site. The rash appeared approximately 6 weeks after initiating PD. She used a heating pad nightly during PD for dialysis drain pain. Testing for systemic and autoimmune disease was negative. She was referred to dermatology, where the diagnosis of erythema ab igne (EAI), a well-described but less well-known hyperpigmented reticular cutaneous eruption caused by chronic exposure to low levels of infrared heat, was confirmed. The eruption is typically painless but is often pruritic. Common sources of heat include fires, stoves, portable heaters, heating pads, and laptop computers. The association between EAI and PD is unknown. Our patient discontinued the heating pad and her rash resolved.

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Validation and Cross-Cultural Adaptation of the Spanish Version of the Pain Sensitivity Questionnaire (PSQ-S)

Journal of Clinical Medicine ◽

10.3390/jcm11010151 ◽

2021 ◽

Vol 11 (1) ◽

pp. 151

Author(s):

María del Rocío Ibancos-Losada ◽

María Catalina Osuna-Pérez ◽

Irene Cortés-Pérez ◽

Desirée Montoro-Cárdenas ◽

Ángeles Díaz-Fernández

Keyword(s):

Chronic Pain ◽

Cultural Adaptation ◽

Pain Sensitivity ◽

Experimental Pain ◽

Cross Cultural ◽

Cross Cultural Adaptation ◽

Chronic Pain Patients ◽

Two Factors ◽

Pain Testing ◽

Pain Patients

Experimental pain testing requires specific equipment and may be uncomfortable for patients. The Pain Sensitivity Questionnaire (PSQ) was developed to assess pain sensitivity, based on the pain intensity ratings (range: 0–10) of painful situations that occur in daily life. The main objective of this study was to carry out a cross-cultural adaptation and validation of the Spanish version of the PSQ (PSQ-S). A total of 354 subjects (296 healthy and 58 chronic pain patients) filled in the PSQ-S. A subgroup of 116 subjects performed experimental pain testing, including two modalities (cold and pressure), with different measures: pain intensity rating, pressure pain threshold, and tolerance. The validation results showed two factors: PSQ-S-moderate and PSQ-S-minor and, for the total scale and the two factors, an excellent internal consistency (Cronbach’s alpha coefficient > 0.9) and a substantial reliability (Intraclass Correlation Coefficient > 0.8). We obtained strong correlations with all the experimental pain rating parameters, catastrophizing, and depression variables, as well as moderate correlations with anxiety, central sensibilization, and impact on the quality of life. Chronic pain patients received elevated PSQ-S scores compared to healthy controls, and three cut-off values (PSQ-S-total = 7.00, PSQ-S-moderate = 7.57, and PSQ-S-minor = 6.29) based on ROC curve analyses were shown to be able to discriminate between healthy adults and adults with chronic pain. Therefore, PSQ-S may be a simple alternative to experimental pain procedures for clinical and experimental pain research.

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(328) Pain catastrophizing assessed before and after experimental pain testing: Temporal stability and relations with pain and nociception

Journal of Pain ◽

10.1016/j.jpain.2008.01.251 ◽

2008 ◽

Vol 9 (4) ◽

pp. 58 ◽

Cited By ~ 1

Author(s):

J. Russell ◽

E. Bartley ◽

K. McCabe ◽

A. Williams ◽

J. Rhudy

Keyword(s):

Pain Catastrophizing ◽

Temporal Stability ◽

Experimental Pain ◽

Before And After ◽

Pain Testing

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Negative laparoscopy unveiled

Journal of Endometriosis and Pelvic Pain Disorders ◽

10.1177/2284026517749478 ◽

2018 ◽

Vol 10 (1) ◽

pp. 18-21 ◽

Cited By ~ 1

Author(s):

John Jarrell ◽

Lars Arendt-Nielsen

Keyword(s):

Pelvic Pain ◽

Chronic Pelvic Pain ◽

Visceral Pain ◽

Clinic Visit ◽

Observer Error ◽

Acute Pelvic Pain ◽

Pain Sensitization ◽

Student’S T ◽

Nociceptive Input ◽

Pain Testing

Introduction: Studies indicate a variable proportion of laparoscopies done for the management of non-acute pelvic pain that do not identify visible pathology and are called negative laparoscopies. Possible explanations have included undetected endometriosis, observer error, and/or neural tissues in the endometrium acting as nociceptive input. The goal was to compare demographic and pain testing measures between women with negative laparoscopies and confirmed endometriosis in a cohort of women presenting with chronic pelvic pain. Methods: Women with chronic pelvic pain (n = 255) provided written consent for the study prior to entry. Data were collected at the time of clinic visit and entered contemporaneously into SPSS. Pain sensitization was identified as the presence of cutaneous allodynia. Clinical, pain, and pain sensitization variables were compared using Student’s t-test. Results: The frequency of negative laparoscopy was 13.7% (35 cases) and that of confirmed endometriosis was 27.1% (69 cases). There were no differences between women with a negative laparoscopy and women with confirmed endometriosis in clinical, dysmenorrhea, or pain testing measurements. Conclusion: The data suggest in the absence of endometriotic tissue in the pelvis, chronic visceral pain may result from a uterine origin and result in a generalized pattern of pain and pain sensitization.

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