scholarly journals Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012

2014 ◽  
Vol 20 (7) ◽  
pp. 678-682 ◽  
Author(s):  
N. Khuri-Bulos ◽  
D.C. Payne ◽  
X. Lu ◽  
D. Erdman ◽  
L. Wang ◽  
...  
2020 ◽  
Author(s):  
Agnes Jessica Lubis

Coronavirus adalah virus RNA dengan ukuran partikel 120-160 nm. Virus ini utamanya menginfeksi hewan, di antaranya adalah kelelawar dan unta. Sebelum terjadinya wabah COVID-19, ada 6 jenis coronavirus yang dapat menginfeksi manusia, yaitu alphacoronavirus 229E, alphacoronavirus NL63, betacoronavirus OC43, betacoronavirus HKU1, Severe Acute Respiratory Illness Coronavirus (SARS-CoV), dan Middle East Respiratory Syndrome Coronavirus (MERS-CoV).Coronavirus yang menjadi etiologi COVID-19 termasuk dalam genus betacoronavirus. Hasil analisis filogenetik menunjukkan bahwa virus ini masuk dalam subgenus yang sama dengan coronavirus yang menyebabkan wabah Severe Acute Respiratory Illness (SARS) pada 2002-2004 silam, yaitu Sarbecovirus. Atas dasar ini, International Committee on Taxonomy of Viruses mengajukan nama SARS-CoV-2.


2019 ◽  
Vol 75 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Thi Hong Van Nguyen ◽  
Julie Lichière ◽  
Bruno Canard ◽  
Nicolas Papageorgiou ◽  
Sarah Attoumani ◽  
...  

Middle East respiratory syndrome coronavirus (MERS-CoV) is a human pathogen responsible for a severe respiratory illness that emerged in 2012. Structural information about the proteins that constitute the viral particle is scarce. In order to contribute to a better understanding of the nucleoprotein (N) in charge of RNA genome encapsidation, the structure of the C-terminal domain of N from MERS-CoV obtained using single-crystal X-ray diffraction is reported here at 1.97 Å resolution. The molecule is present as a dimer in the crystal structure and this oligomerization state is confirmed in solution, as measured by additional methods including small-angle X-ray scattering measurements. Comparisons with the structures of the C-terminal domains of N from other coronaviruses reveals a high degree of structural conservation despite low sequence conservation, and differences in electrostatic potential at the surface of the protein.


2020 ◽  
Vol 10 (3) ◽  
pp. 251-253
Author(s):  
Tooba Masood

Coronavirus belongs to a large family of viruses that usually cause respiratory illness in human beings that can be mild and severe depending upon the strain. In 2002, the outbreak of SARS (severe acute respiratory syndrome) reported more than 8000 infected cases with 774 mortalities. In 2012, the outbreak of MERS (middle east respiratory syndrome) infected around 2494 people and 858 deaths were reported according to the WHO. In January 2020, a new strain of coronavirus named 2019-nCoV has been identified in China. The number of confirmed cases has been increasing reaching 5,593,631 cases worldwide with 353,334 deaths up till 28th May 2020 according to WHO situation report-129. Concerned authorities are working on minimizing its spread. Prevention guidelines have been released by WHO, hoping to control the transmission and save the world from the effects of this novel virus.


2021 ◽  
Author(s):  
Mitra Gultom ◽  
Annika Kratzel ◽  
Jasmine Portmann ◽  
Hanspeter Stalder ◽  
Astrid Chanfon Baetzner ◽  
...  

In 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in Saudi Arabia and was mostly associated with severe respiratory illness in humans. Dromedary camels are the zoonotic reservoir for MERS-CoV. To investigate the biology of MERS-CoV in camelids, we developed a well-differentiated airway epithelial cell (AEC) culture model for Llama glama and Camelus bactrianus. Histological characterization revealed progressive epithelial cellular differentiation with well-resemblance to autologous ex vivo tissues. We demonstrate that MERS-CoV displays a divergent cell tropism and replication kinetics profile in both AEC models. Furthermore, we observed that in the camelid AEC models MERS-CoV replication can be inhibited by both type I and III interferons (IFNs). In conclusion, we successfully established camelid AEC cultures that recapitulate the in vivo airway epithelium and reflect MERS-CoV infection in vivo. In combination with human AEC cultures, this system allows detailed characterization of the molecular basis of MERS-CoV cross-species transmission in respiratory epithelium. 


Author(s):  
Shoaib Shareef ◽  
Sawera Khalil ◽  
Muhammad Shahid Sharif

Coronavirus is a common virus causing very serious issues to public health. This virus, SARS-COV-2, has disseminated worldwide respiratory illness, designated as COVID-19. This viral infection disturbs people in various ways. A lot of people infested due to this virus develop a mild illness and get relief soon without any sort of hospitalization. But mostly, it becomes highly severe later and the patient has to undergo shortening of breath as well as some other chest-related abnormalities like Middle East Respiratory Syndrome (MERS) and Acute Respiratory Syndrome. In this manuscript, we have discussed multiple areas like symptomatology, management approaches including Homoeopathic and Allopathic (drugs) treatments, plus vaccination.  Lastly, we have put in the conclusion of overall literature, and most importantly implicated or suggested certain new research areas for the researchers to explore which may assist in preventing further spread of this threatening syndrome now and in the future.


2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Nahed Seddiq ◽  
Manaf Al-Qahtani ◽  
Jaffar A. Al-Tawfiq ◽  
Nazar Bukamal

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is well known to cause severe respiratory infection and was first reported in the Kingdom of Saudi Arabia in 2012. We report here the first confirmed MERS-CoV infection in the Kingdom of Bahrain in a Saudi gentleman who was admitted electively for coronary bypass surgery, postoperatively developed an acute respiratory illness, and tested positive for MERS-CoV. 40 close contacts, all healthcare workers, were traced and followed with no documented secondary cases.


2020 ◽  
Vol 5 (4) ◽  
pp. 1006-1010
Author(s):  
Jennifer Raminick ◽  
Hema Desai

Purpose Infants hospitalized for an acute respiratory illness often require the use of noninvasive respiratory support during the initial stage to improve their breathing. High flow oxygen therapy (HFOT) is becoming a more popular means of noninvasive respiratory support, often used to treat respiratory syncytial virus/bronchiolitis. These infants present with tachypnea and coughing, resulting in difficulties in coordinating sucking and swallowing. However, they are often allowed to feed orally despite having high respiratory rate, increased work of breathing and on HFOT, placing them at risk for aspiration. Feeding therapists who work with these infants have raised concerns that HFOT creates an additional risk factor for swallowing dysfunction, especially with infants who have compromised airways or other comorbidities. There is emerging literature concluding changes in pharyngeal pressures with HFOT, as well as aspiration in preterm neonates who are on nasal continuous positive airway pressure. However, there is no existing research exploring the effect of HFOT on swallowing in infants with acute respiratory illness. This discussion will present findings from literature on HFOT, oral feeding in the acutely ill infant population, and present clinical practice guidelines for safe feeding during critical care admission for acute respiratory illness. Conclusion Guidelines for safety of oral feeds for infants with acute respiratory illness on HFOT do not exist. However, providers and parents continue to want to provide oral feeds despite clinical signs of respiratory distress and coughing. To address this challenge, we initiated a process change to use clinical bedside evaluation and a “cross-systems approach” to provide recommendations for safer oral feeds while on HFOT as the infant is recovering from illness. Use of standardized feeding evaluation and protocol have improved consistency of practice within our department. However, further research is still necessary to develop clinical practice guidelines for safe oral feeding for infants on HFOT.


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