A history of mental illness, but not of conception with assisted reproductive technology, puts patients at increased risk of severe postnatal depression

AbstractThe majority of offspring born following assisted reproductive technology (ART) achieve equivalent development milestones and demonstrate comparable health as spontaneously conceived children. Yet, multiple studies have suggested offspring conceived with ART have slightly increased risk of metabolic derangements, cardiovascular disease, and malignancy. However, the associations observed in these studies often inadequately control for a variety of confounding variables, such as multiple gestation, premature birth, and low birth weight. Furthermore, many studies fail to account for the increased risk of many of these pathologies in the offspring of subfertile women in general. Lastly, the absolute risk of most of the ailments studied is extremely low. In nearly all examples, the number of women who would need to be treated to observe one additional diagnosis is substantially high. When compared with the number of couples who would have remained childless due to severe male factor infertility or would have been exposed to the risk of passing on a severe monogenic disorder, the general increased risks to ART-exposed children is very small.

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Physical illness leading to absence from work and the risk of subsequent suicide: a national register-based study

European Journal of Public Health ◽

10.1093/eurpub/ckz101 ◽

2019 ◽

Vol 29 (6) ◽

pp. 1073-1078 ◽

Cited By ~ 3

Author(s):

Fang Tang ◽

Lars Mehlum ◽

Ingrid S Mehlum ◽

Ping Qin

Keyword(s):

Mental Illness ◽

Suicide Risk ◽

Conditional Logistic Regression ◽

Physical Illness ◽

Income Status ◽

Increased Risk ◽

Physical Health Problems ◽

History Of ◽

Absence From Work ◽

Nested Case Control

Abstract Background Studies have shown that people with physical illness are at increased risk of suicide, but knowledge on the association between absence from work due to specific physical health problems and suicide risk is limited. This study aimed to examine the relationship between suicide risk and physical illness requiring leave from work across a range of specific physical diagnoses, and to study the interactions of mental illness and socioeconomic factors on this relationship. Methods Using a nested case-control design, 9313 suicide cases and 169 235 matched controls were retrieved and interlinked from Norwegian national registries. Data on sick leave and related physical illness were derived from claims for sickness benefit and analyzed using conditional logistic regression. Results For males, the risk of suicide increased progressively with the number of previous physical illness-related absences and the duration of recent physical illness-related absences. Absences related to digestive, musculoskeletal and neurological disorders as well as cancer and accidents/injuries were associated with a significantly increased risk of suicide. In contrast, females with a history of physical illness-related absence and a diagnosis of most organ or system specific illnesses were at a relatively reduced risk of suicide. In both genders, the suicide risk associated with physical illness resulting in absence from work differentiated significantly by history of sickness absence due to mental illness, and by education and income levels. Conclusions The risk of suicide associated with physical illness requiring leave from work varied significantly by gender and by education and income status.

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Rates and profile of victimization in a sample of Egyptian patients with major mental illness

International Journal of Social Psychiatry ◽

10.1177/0020764019831315 ◽

2019 ◽

Vol 65 (3) ◽

pp. 183-193 ◽

Cited By ~ 2

Author(s):

Ahmed El Missiry ◽

Marwa Abd El Meguid ◽

Ahmed Abourayah ◽

Marwa El Missiry ◽

Mohamed Hossam ◽

...

Keyword(s):

Mental Illness ◽

Rural Areas ◽

Global Assessment Of Functioning ◽

Personal Issue ◽

Demographic Questionnaire ◽

Increased Risk ◽

Egyptian Patients ◽

History Of ◽

Study Population ◽

Axis I

Background: Patients with major mental illness have an increased risk of victimization. Nevertheless, this topic was not thoroughly studied in Egyptian patients with major mental illness. Objectives: The objectives of this study are to investigate the rates of victimization and understand its profile, psycho-demographic and clinical correlates among a sample of Egyptian patients with major mental illness. Participants and Methods: A total of 300 patients (100 patients with schizophrenia, 100 with bipolar and 100 with major depression) were recruited from the inpatient wards and outpatient clinics at Ain Shams University. They were subjected to a demographic questionnaire, the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Global Assessment of Functioning (GAF), Clinical Global Impression (CGI) and a Victimization Questionnaire (VQ). Results: In our study population, 130 (43.3%) of patients were victimized, of them 52 (40%) were diagnosed with major depressive disorder, 48 (36.9%) with bipolar disorder and 30 (23.1%) with schizophrenia. Victimization was more in female, married, unemployed individuals and those living in rural areas. Patients exposed to domestic violence or abuse during childhood had higher rates of victimization. All victimized patients were subjected to emotional victimization, 64.6% were physically victimized and 53.8% were subjected to miscellaneous types of victimization. Patients were victimized mainly by acquaintance followed by family members. The majority of patients did not report their victimization and considered it as a personal issue or not important enough to be reported. Conclusion: Patients with major mental illness are susceptible to significant victimization. Clinicians should explore possible history of abuse or victimization in their patients, empower and support the victimized ones.

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Endometrioma surgery is associated with increased risk of subsequent assisted reproductive technology cycle cancellation; a retrospective cohort study

Journal of Obstetrics and Gynaecology ◽

10.1080/01443615.2020.1754366 ◽

2020 ◽

pp. 1-4

Author(s):

Yavuz Emre Şükür ◽

Batuhan Özmen ◽

Betül Yakıştıran ◽

Cem Somer Atabekoğlu ◽

Bülent Berker ◽

...

Keyword(s):

Cohort Study ◽

Assisted Reproductive Technology ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Reproductive Technology ◽

Increased Risk ◽

Cycle Cancellation

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The Relationship of Assisted Reproductive Technology on Perinatal Outcomes in Triplet Gestations

American Journal of Perinatology ◽

10.1055/s-0038-1660457 ◽

2018 ◽

Vol 35 (14) ◽

pp. 1388-1393 ◽

Cited By ~ 1

Author(s):

Jaimin Shah ◽

Tania Roman ◽

Oscar Viteri ◽

Ziad Haidar ◽

Alejandra Ontiveros ◽

...

Keyword(s):

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Assisted Reproductive Technology ◽

Distress Syndrome ◽

Perinatal Death ◽

Periventricular Leukomalacia ◽

Perinatal Outcomes ◽

Neonatal Morbidity ◽

Reproductive Technology ◽

Increased Risk

Objective To assess whether assisted reproductive technology (ART) is associated with increased risk of adverse perinatal outcomes in triplet gestations compared with spontaneous conception. Study Design Secondary analysis of a multicenter randomized trial for the prevention of preterm birth in multiple gestations. Triplets delivered at ≥ 24 weeks were studied. The primary outcome was the rate of composite neonatal morbidity (CNM) that included one or more of the following: bronchopulmonary dysplasia, respiratory distress syndrome, necrotizing enterocolitis, culture proven sepsis, pneumonia, retinopathy of prematurity, intraventricular hemorrhage, periventricular leukomalacia, or perinatal death. Results There were 381 triplets (127 women) of which 89 patients conceived via ART and 38 patients spontaneously. Women with ART were more likely to be older, Caucasian, married, nulliparous, have higher level of education, and develop pre-eclampsia. Spontaneously conceived triplets were more likely to delivery at an earlier gestation (31.2 ± 3.5 vs 32.8 ± 2.7 weeks) (p = 0.009) with a lower birth weight (p < 0.001). After adjusting for confounders, no differences were noted in culture proven sepsis, perinatal death, CNM, respiratory distress syndrome, or Apgar score < 7 at 5 minutes. All remaining perinatal outcomes were similar. Conclusion Triplets conceived by ART had similar perinatal outcomes compared with spontaneously conceived triplets.

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General medical disorders with psychiatric implications

10.1093/med/9780199360574.003.0038 ◽

2015 ◽

Author(s):

Erik J. Garcia ◽

Warren J. Ferguson

Keyword(s):

Mental Illness ◽

Psychiatric Symptoms ◽

The United States ◽

Prior History ◽

Medical Illness ◽

Medical Conditions ◽

Presenting Symptoms ◽

Medical Disorders ◽

Increased Risk ◽

History Of

Traditionally the domain of consultation/ liaison psychiatry, the challenge of recognizing and then appropriately treating the psychiatric complications of general medical disorders requires thoughtful planning and attention in corrections. Medical conditions that have psychiatric symptoms represent a significant diagnostic dilemma, particularly in the correctional health setting. Over half of the inmates in the United States have symptoms of a major mental illness, but the pervasiveness of substance use disorders, the increasing prevalence of elderly inmates, and limited access to a patient’s past medical and psychiatric records all contribute to the challenge of discerning when a psychiatric presentation results from an underlying medical condition. One early study underscored this challenge, noting that 46% of the patients admitted to community psychiatric wards had an unrecognized medical illness that either caused or exacerbated their psychiatric illness. A more recent study observed that 2.8% of admissions to inpatient psychiatry were due to unrecognized medical conditions. Emergency room medical clearance of patients presenting for psychiatric admission has revealed an increased risk for such underlying medical conditions among patients with any of five characteristics: elderly, a history of substance abuse, no prior history of mental illness, lower socioeconomic status, or significant preexisting medical illnesses. This chapter examines several of these risk groups and focuses on the presenting symptoms of delirium, mood disorders, and psychosis and the underlying medical conditions that can mimic or exacerbate them.

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