We are in an era of rapid change and the gradual opening of changes push us to make a lot of new theories and thinking to deal with the problems faced very different from previous close, and open and at the same time so that we can think about making reference to external experience. In this case, how should the planning, design, organization and implementation of both compatible with the current state of the personnel system requirements for the current situation of reform, but also has certain forward-looking human resources management system, is currently engaged in human resource management for all staff challenge. Based on this, the era of knowledge from four aspects of human resource management and knowledge management integration were discussed and presented the basic ideas.