Pseudosciaena crocea
            roe protein‐stabilized emulsions for oral delivery systems:
            In vitro
            digestion and
            in situ
            intestinal perfusion study

In this paper, we demonstrate for the first time the use of gliadin particles to structure algal oil (rich in DHA) and to exert chemical stability against lipid oxidation via the Pickering high internal phase emulsion (HIPE) strategy.

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Gelatin Particle-Stabilized High-Internal Phase Emulsions for Use in Oral Delivery Systems: Protection Effect and in Vitro Digestion Study

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.6b04705 ◽

2017 ◽

Vol 65 (4) ◽

pp. 900-907 ◽

Cited By ~ 45

Author(s):

Huan Tan ◽

Lifeng Zhao ◽

Sisi Tian ◽

Hui Wen ◽

Xiaojun Gou ◽

...

Keyword(s):

Oral Delivery ◽

In Vitro Digestion ◽

Delivery Systems ◽

Protection Effect ◽

Internal Phase ◽

Oral Delivery Systems

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[6]-Shogaol/β-CDs inclusion complex: preparation, characterisation, in vivo pharmacokinetics, and in situ intestinal perfusion study

Journal of Microencapsulation ◽

10.1080/02652048.2019.1649480 ◽

2019 ◽

Vol 36 (5) ◽

pp. 500-512 ◽

Cited By ~ 2

Author(s):

Ran Li ◽

Rui Bao ◽

Qiu-Xuan Yang ◽

Qi-Long Wang ◽

Michael Adu-Frimpong ◽

...

Keyword(s):

Inclusion Complex ◽

Intestinal Perfusion ◽

Perfusion Study ◽

Complex Preparation ◽

In Situ Intestinal Perfusion ◽

In Vivo Pharmacokinetics

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In vitro Evaluation of Arabinoxylan Gels as an Oral Delivery System for Insulin

MRS Proceedings ◽

10.1557/opl.2012.1529 ◽

2012 ◽

Vol 1487 ◽

Cited By ~ 3

Author(s):

E. Carvajal-Millan ◽

C. Berlanga-Reyes ◽

A. Rascón-Chu ◽

A. L. Martínez-López ◽

J. A. Márquez-Escalante ◽

...

Keyword(s):

Diffusion Coefficient ◽

Apparent Diffusion Coefficient ◽

Delivery System ◽

Oral Delivery ◽

Delivery Systems ◽

Oral Delivery System ◽

Apparent Diffusion ◽

Oral Delivery Systems ◽

Hydrolysis Of

ABSTRACTArabinoxylan gels are receiving increasing attention as oral delivery systems of biomolecules for therapeutic purposes. The aim of this research was to evaluate arabinoxylan gels as an oral delivery system for insulin, representing a painless therapy for diabetics. Gels at two concentrations of arabinoxylan were prepared (2.5 and 3.5 % w/v). One concentration of insulin (0.05 % w/v) entrapped in the arabinoxylan gels was investigated. At the end of gelation elasticity (G’) values were 11 and 20 for gels at 2.5 and 3.5% (w/v) in arabinoxylan, respectively. The presence of insulin in the gels did not affect the values of G’. The apparent diffusion coefficient for insulin decreased from 1.30 x 10-7 to 1.09 x 10-7 cm2/s when the concentration of arabinoxylan in the gel increased from 2.5 to 3.5% (w/v). The percentage of proteolysis for insulin entrapped in the gels at 2.5 and 3.5% in arabinoxylan (w/v) were 35 and 17%, respectively, in relation to 100% hydrolysis of insulin in solution. Results indicate that arabinoxylan gels could be potential candidates as oral delivery systems for insulin.

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