SLC Neurotransmitter Transporters as Therapeutic Targets for Alcohol Use Disorder: A Narrative Review

2020 ◽  
Author(s):  
Eliza R. McColl ◽  
Micheline Piquette‐Miller
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Therapeutic Targets ◽  
Narrative Review ◽  
Neurotransmitter Transporters

scholarly journals Cyclic nucleotide phosphodiesterases: potential therapeutic targets for alcohol use disorder

2018 ◽  
Vol 235 (6) ◽  
pp. 1793-1805 ◽  
Author(s):  
Rui-Ting Wen ◽  
Fang-Fang Zhang ◽  
Han-Ting Zhang
Keyword(s):  
Alcohol Use ◽  
Cyclic Nucleotide ◽  
Alcohol Use Disorder ◽  
Therapeutic Targets ◽  
Cyclic Nucleotide Phosphodiesterases ◽  
Nucleotide Phosphodiesterases

scholarly journals Alcohol consumption and alcohol-related problems during the COVID-19 pandemic: a narrative review

2020 ◽  
Vol 28 (5) ◽  
pp. 524-526 ◽  
Author(s):  
Rodrigo Ramalho
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Partner Violence ◽  
Alcohol Use Disorder ◽  
Mental Health Problems ◽  
Narrative Review ◽  
Excessive Alcohol Consumption ◽  
Potential Increase ◽  
The Impact ◽  
Alcohol Related Problems

Objective: To summarise publications reporting on alcohol consumption and alcohol-related problems during the Coronavirus disease 2019 (COVID-19) pandemic in a narrative review. Methods: ProQuest, Web of Science and Google Scholar were searched for articles published in 2020. This search used two terms: ‘alcohol’ and ‘COVID’. Reference lists of articles were reviewed to identify additional articles. Results: There is growing concern around an increase in alcohol intake and alcohol-related harms. These concerns are related to the impact of excessive alcohol consumption in a person with COVID-19 and/or with alcohol use disorder, as well as with a potential increase in the prevalence of harmful drinking, alcohol use disorder, withdrawal symptoms, intimate partner violence, harm to children, suicide, mental health problems and non-communicable diseases. The need for assessing alcohol use and providing adequate advice during the pandemic have been highlighted. Conclusion: The time for action is now, and all necessary measures to prevent an increase in alcohol-related problems should be adopted. At the same time, healthcare services should also prepare for such potential increase, while adapting to the exceptional circumstances presented by the pandemic, such as physical distancing.

Thiamine Substitution in Alcohol Use Disorder: A Narrative Review of Medical Guidelines

2019 ◽  
Vol 25 (3) ◽  
pp. 103-110 ◽  
Author(s):  
Nathalie Pruckner ◽  
Josef Baumgartner ◽  
Barbara Hinterbuchinger ◽  
Alexander Glahn ◽  
Sandra Vyssoki ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Narrative Review ◽  
Medical Guidelines

scholarly journals Receptor Tyrosine Kinases as Therapeutic Targets for Alcohol Use Disorder

2019 ◽  
Vol 17 (1) ◽  
pp. 4-16 ◽  
Author(s):  
Kana Hamada ◽  
Amy W. Lasek
Keyword(s):  
Alcohol Use ◽  
Tyrosine Kinases ◽  
Alcohol Use Disorder ◽  
Receptor Tyrosine Kinases ◽  
Therapeutic Targets

DSM-5 alcohol use disorder features among treatment-seeking older adults

2018 ◽  
Vol 64 (4) ◽  
pp. 185-196 ◽  
Author(s):  
Silke Behrendt ◽  
Barbara Braun ◽  
Randi Bilberg ◽  
Gerhard Bühringer ◽  
Michael Bogenschutz ◽  
...  
Keyword(s):  
Older Adults ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
The Elderly ◽  
Treatment Seeking ◽  
Controlled Clinical Trial ◽  
Dsm 5 ◽  
Wide Range ◽  
And Gender ◽  
International Multicenter

Abstract. Background: The number of older adults with alcohol use disorder (AUD) is expected to rise. Adapted treatments for this group are lacking and information on AUD features in treatment seeking older adults is scarce. The international multicenter randomized-controlled clinical trial “ELDERLY-Study” with few exclusion criteria was conducted to investigate two outpatient AUD-treatments for adults aged 60+ with DSM-5 AUD. Aims: To add to 1) basic methodological information on the ELDERLY-Study by providing information on AUD features in ELDERLY-participants taking into account country and gender, and 2) knowledge on AUD features in older adults seeking outpatient treatment. Methods: baseline data from the German and Danish ELDERLY-sites (n=544) were used. AUD diagnoses were obtained with the Mini International Neuropsychiatric Interview, alcohol use information with Form 90. Results: Lost control, desired control, mental/physical problem, and craving were the most prevalent (> 70 %) AUD-symptoms. 54.9 % reported severe DSM-5 AUD (moderate: 28.2 %, mild: 16.9 %). Mean daily alcohol use was 6.3 drinks at 12 grams ethanol each. 93.9 % reported binging. More intense alcohol use was associated with greater AUD-severity and male gender. Country effects showed for alcohol use and AUD-severity. Conclusion: European ELDERLY-participants presented typical dependence symptoms, a wide range of severity, and intense alcohol use. This may underline the clinical significance of AUD in treatment-seeking seniors.

Persönliche vs. computerbasierte Alkoholintervention für Krankenhauspatienten: Studiendesign

2015 ◽  
Vol 61 (6) ◽  
pp. 347-355 ◽  
Author(s):  
Jennis Freyer-Adam ◽  
Sophie Baumann ◽  
Inga Schnuerer ◽  
Katja Haberecht ◽  
Ulrich John ◽  
...  
Keyword(s):  
Public Health ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Identification Test ◽  
Disorder Identification

Zusammenfassung. Ziel: Persönliche Beratungen können bei stationären Krankenhauspatienten Alkoholkonsum und Mortalität reduzieren. Sie sind jedoch mit hohen Kosten verbunden, wenn aus Public-Health-Erfordernis viele Menschen einer Bevölkerung erreicht werden müssen. Computerbasierte Interventionen stellen eine Alternative dar. Jedoch ist ihre Wirksamkeit im Vergleich zu persönlichen Beratungen und im Allgemeinkrankenhaus noch unklar. Eine quasi-randomisierte Kontrollgruppenstudie „Die Bedeutung der Vermittlungsform für Alkoholinterventionen bei Allgemeinkrankenhauspatienten: Persönlich vs. Computerisiert“ soll dies untersuchen. Design und Methoden werden beschrieben. Methode: Über 18 Monate sind alle 18- bis 64-jährigen Patienten auf Stationen der Universitätsmedizin Greifswald mittels Alcohol Use Disorder Identification Test (AUDIT) zu screenen. Frauen/Männer mit AUDIT-Consumption ≥ 4/5 und AUDIT < 20 werden einer von drei Gruppen zugeordnet: persönliche Intervention (Beratungen zur Konsumreduktion), computerbasierte Intervention (individualisierte Rückmeldebriefe und Broschüren) und Kontrollgruppe. Beide Interventionen erfolgen im Krankenhaus sowie telefonisch bzw. postalisch nach 1 und 3 Monaten. In computergestützten Telefoninterviews nach 6, 12, 18 und 24 Monaten wird Alkoholkonsum erfragt. Schlussfolgerung: Das Studienvorhaben, sofern erfolgreich umgesetzt, ist geeignet die längerfristige Wirksamkeit einer persönlichen und computerbasierten Intervention im Vergleich zu untersuchen.

Cognitive Avoidance Is Ineffective for Patients With Alcohol Use Disorder and Low Self-Efficacy

2007 ◽  
Author(s):  
C. Levin ◽  
M. Ilgen ◽  
R. Moos
Keyword(s):  
Alcohol Use ◽  
Self Efficacy ◽  
Alcohol Use Disorder ◽  
Cognitive Avoidance
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