Impaired Treg and NK cells profile in overweight women with gestational diabetes mellitus

2018 ◽  
Vol 79 (3) ◽  
pp. e12810 ◽  
Author(s):  
Thalita Frutuoso Lobo ◽  
Camila de Moraes Borges ◽  
Rosiane Mattar ◽  
Caio Perez Gomes ◽  
Ana Geisa Santos de Angelo ◽  
...  
2018 ◽  
Vol 42 (2) ◽  
pp. 149-156 ◽  
Author(s):  
T. F. Lobo ◽  
M. R. Torloni ◽  
R. Mattar ◽  
M. U. Nakamura ◽  
S. M. Alexandre ◽  
...  

Author(s):  
P. Selvi ◽  
V. Manivannan ◽  
G. Liji Martina ◽  
V. Senbagavalli ◽  
C. Selvin Thanuja ◽  
...  

Background: Gestational Diabetes Mellitus (GDM) is currently treated with blood sugar monitoring, nutritional supplements, increased fatal police work, and hypoglycemic agent medical help PRN to achieve and maintain normoglycemia. Even though humulin therapy has been demonstrated to reduce low birth weight in women with GDM, using hypoglycemic drugs is likely challenging and may not address peripheral hypoglycemic agent resistance, which is a critical role in the development of GDM. Furthermore, the use of aggressive low blood sugar medication therapy may result in a twofold rise in the amount of small-for-gestational-age infants. The resistance exercise was used in overweight women with Gestational Diabetes Mellitus. Because resistance exercise increase the lean body muscle or decrease the body fat and Resistance exercise is an effective glycaemic management and cardio metabolic health strategy. Methods: Fifteen patients with physiological condition DM were arbitrarily assigned whether it's to a group that received strength training or to a group that did not receive strength training to scale back the necessity for the hypoglycaemic agent. Results: Despite therapy, the number of girls who required hypoglycemic agent medical care has been the same. However, a meta-analysis with only overweight girls (pre-pregnancy BMI) revealed that the exercise cluster used to have a lower rate of hypoglycemic medication use (P<05) than that of the non-exercise receiving patients. Conclusion: Resistance exercise coaching might facilitate to avoid hypoglycaemic agent medical aid for pregnant overweight girls with physiological state diabetes


PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95094 ◽  
Author(s):  
Meireluci Costa Ribeiro ◽  
Mary Uchiyama Nakamura ◽  
Maria Regina Torloni ◽  
Marco de Tubino Scanavino ◽  
Flávia Burin Scomparini ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Makarios Eleftheriades ◽  
Christos Chatzakis ◽  
Eftychia Papachatzopoulou ◽  
Vassilis Papadopoulos ◽  
Irene Lambrinoudaki ◽  
...  

Abstract Introduction The identification of pregnant women with Gestational Diabetes Mellitus (GDM) who will require insulin therapy, may modify their management to closer monitoring and probable early interventions. The aim of the study was to develop a predictive model for the necessity of insulin treatment in women with GDM. Materials and methods This was a prospective cohort study. Data from 775 women diagnosed with GDM per the IADPSG criteria were analyzed using logistic regression and a machine learning algorithm, the Classification and Regression Trees (CART). Potential predictors routinely recorded at follow-up visits were tested and used for the development of the model. The resultant model was externally validated using the data from two different perinatology clinics. Results Preconceptional maternal BMI and morning fasting blood glucose levels at baseline and at 1 h during an Oral Glucose Tolerance Test (OGTT) were independent significant predictors for the treatment modality of GDM. Baseline blood glucose greater than 98 mg/dl and preconceptional maternal Body Mass Index (BMI) between 26 and 31 kg/height2 increased substantially the probability of insulin therapy (odds ratio [OR] 4.04, 95% confidence interval [CI] CI 2.65–6.17 and 2.21, 95%CI 1.42–3.43, respectively). The area under the curve (AUC) for the internal and external validation of the predictive model was 0.74 and 0.77, respectively. Conclusions A simple model based on maternal characteristics and the values of an OGTT can predict the need for insulin treatment with accuracy. Overweight women with an abnormal baseline blood glucose at OGTT are at high likelihood for insulin treatment. Key message Fifteen to 30% of women with Gestational Diabetes Mellitus (GDM) require insulin therapy. Overweight women with baseline blood glucose greater than 98 mg/dl at OGTT are at increased risk for insulin treatment and close monitoring and increased physical exercise are required.


2016 ◽  
Vol 22 ◽  
pp. 233-234
Author(s):  
Md Abdullah Mamun ◽  
Subrina Jesmin ◽  
Md. Arifur Rahman ◽  
Md Majedul Islam ◽  
Farzana Sohael ◽  
...  

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