Restoration of the apoptosis pathways’ proteins levels after orchiectomy in testicular tumour patients

Andrologia ◽  
2020 ◽  
Vol 52 (11) ◽  
Author(s):  
Larissa Berloffa Belardin ◽  
Maria Beatriz Ribeiro Andrade ◽  
Paula Intasqui ◽  
Deborah Montagnini Spaine ◽  
Ricardo Pimenta Bertolla ◽  
...  
Keyword(s):  
Testicular Tumour ◽  
Apoptosis Pathways

Molecular Mechanism of Apoptosis Induction by Resveratrol, a Natural Cancer Chemopreventive Agent

2008 ◽  
Vol 78 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Fan ◽  
Jiang ◽  
Zhang ◽  
Bai
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanism ◽  
Apoptosis Induction ◽  
Protective Agents ◽  
Chemopreventive Agent ◽  
Naturally Occurring ◽  
Apoptosis Pathways ◽  
Present Understanding

In efforts to identify naturally occurring compounds that act as protective agents, resveratrol, a phytoalexin existing in wine, has attracted much interest because of its diverse pharmacological characteristics. Considering that apoptosis induction is the most potent defense approach for cancer treatment, we have tried to summarize our present understanding of apoptosis induction by resveratrol based on the two major apoptosis pathways.

Effect of Dasatinib on Genes Related to Mitotic Catastrophe Pathway in Chronic Myeloid Leukemia Cells

2020 ◽  
Vol 20 ◽  
Author(s):  
Sezgi Kipcak ◽  
Buket Ozel ◽  
Cigir B. Avci ◽  
Leila S. Takanlou ◽  
Maryam S. Takanlou ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Kinase Inhibitors ◽  
Fusion Gene ◽  
Philadelphia Chromosome ◽  
K562 Cells ◽  
Mitotic Catastrophe ◽  
Control Group ◽  
Cancer Therapies ◽  
Apoptosis Pathways

Background: Chronic myeloid leukemia (CML), is characterized by a reciprocal translocation t(9;22) and forms the BCR/ABL1 fusion gene, which is called the Philadelphia chromosome. The therapeutic targets for CML patients which are mediated with BCR/ABL1 oncogenic are tyrosine kinase inhibitors such as imatinib, dasatinib, and nilotinib. The latter two of which have been approved for the treatment of imatinib-resistant or intolerance CML patients. Mitotic catastrophe (MC) is one of the non-apoptotic mechanisms which frequently initiated in types of cancer cells in response to anti-cancer therapies; pharmacological inhibitors of G2 checkpoint members or genetic suppression of PLK1, PLK2, ATR, ATM, CHK1, and CHK2 can trigger DNA-damage-stimulated mitotic catastrophe. PLK1, AURKA/B anomalously expressed in CML cells, that phosphorylation and activation of PLK1 occur by AURKB at centromeres and kinetochores. Objective: The purpose of this study was to investigate the effect of dasatinib on the expression of genes in MC and apoptosis pathways in K562 cells. Methods: Total RNA was isolated from K-562 cells treated with the IC50 value of dasatinib and untreated cells as a control group. The expression of MC and apoptosis-related genes were analyzed by the qRT-PCR system. Results: The array-data demonstrated that dasatinib-treated K562 cells significantly caused the decrease of several genes (AURKA, AURKB, PLK, CHEK1, MYC, XPC, BCL2, and XRCC2). Conclusion: The evidence supply a basis to support clinical researches for the suppression of oncogenes such as PLKs with AURKs in the treatment of types of cancer especially chronic myeloid leukemia.

scholarly journals Testicular tumour: Unusual presentation of an unusual infectious disease

2020 ◽  
Vol 101 ◽  
pp. 162
Author(s):  
S. Aryal ◽  
S. Sharma
Keyword(s):  
Infectious Disease ◽  
Unusual Presentation ◽  
Testicular Tumour

Lactobacillus plantarum DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways

2020 ◽  
Vol 11 (8) ◽  
pp. 753-766
Author(s):  
A.I. Zaydi ◽  
L.-C. Lew ◽  
Y.-Y. Hor ◽  
M.H. Jaafar ◽  
L.-O. Chuah ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
Cognitive Functions ◽  
High Fat Diet ◽  
Normal Diet ◽  
Sprague Dawley ◽  
Brain Health ◽  
High Fat ◽  
Dietary Strategy ◽  
Apoptosis Pathways ◽  
Insight Into

Aging processes affect the brain in many ways, ranging from cellular to functional levels which lead to cognitive decline and increased oxidative stress. The aim of this study was to investigate the potentials of Lactobacillus plantarum DR7 on brain health including cognitive and memory functions during aging and the impacts of high fat diet during a 12-week period. Male Sprague-Dawley rats were separated into six groups: (1) young animals on normal diet (ND, (2) young animals on a high fat diet (HFD), (3) aged animals on ND, (4) aged animals on HFD, (5) aged animals on HFD and L. plantarum DR7 (109 cfu/day) and (6) aged animals receiving HFD and lovastatin. To induce ageing, all rats in group 3 to 6 were injected sub-cutaneously at 600 mg/kg/day of D-galactose daily. The administration of DR7 has reduced anxiety accompanied by enhanced memory during behavioural assessments in aged-HFD rats (P<0.05). Hippocampal concentration of all three pro-inflammatory cytokines were increased during aging but reduced upon administration of both statin and DR7. Expressions of hippocampal neurotransmitters and apoptosis genes showed reduced expressions of indoleamine dioxygenase and P53 accompanied by increased expression of TPH1 in aged- HFD rats administered with DR7, indicating potential effects of DR7 along the pathways of serotonin and oxidative senescence. This study provided an insight into potentials of L. plantarum DR7 as a prospective dietary strategy to improve cognitive functions during aging. This study provided an insight into potentials of L. plantarum DR7 as a prospective dietary strategy to improve cognitive functions during aging.

scholarly journals Apoptosis induced by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS generation through both extrinsic and intrinsic apoptosis pathways

2013 ◽  
Vol 42 (4) ◽  
pp. 1349-1359 ◽  
Author(s):  
JINSHUN ZHAO ◽  
LINDA BOWMAN ◽  
RUTH MAGAYE ◽  
STEPHEN S. LEONARD ◽  
VINCENT CASTRANOVA ◽  
...  
Keyword(s):  
Tungsten Carbide ◽  
Cobalt Nanoparticles ◽  
Ros Generation ◽  
Intrinsic Apoptosis ◽  
Apoptosis Pathways ◽  
Jb6 Cells

scholarly journals P468Proteasomal-dependent defects in apoptosis pathways and apoptosis resistance underlie the expansion of CD4+CD28null T cells in patients with coronary atherosclerosis

2014 ◽  
Vol 103 (suppl 1) ◽  
pp. S85.5-S86
Author(s):  
I E Dumitriu ◽  
E Kovalcsik ◽  
P Baruah ◽  
R Antunes ◽  
JC Kaski
Keyword(s):  
T Cells ◽  
Coronary Atherosclerosis ◽  
Apoptosis Resistance ◽  
Apoptosis Pathways

Tetrandrine and Caffeine Modulated Cell Cycle and Increased Glioma Cell Death via Caspase-Dependent and Caspase-Independent Apoptosis Pathways

2014 ◽  
Vol 66 (4) ◽  
pp. 700-706 ◽  
Author(s):  
Jin-Cherng Chen ◽  
Juen-Haur Hwang ◽  
Wen-Hsuan Chiu ◽  
Yin-Ching Chan
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Glioma Cell ◽  
Apoptosis Pathways

scholarly journals Targeting Apoptosis Pathways in Cancer—Letter

2015 ◽  
Vol 8 (4) ◽  
pp. 338-338 ◽  
Author(s):  
Stephen Safe
Keyword(s):  
Apoptosis Pathways

Apoptosis pathways in neuroblastoma therapy

2003 ◽  
Vol 197 (1-2) ◽  
pp. 131-135 ◽  
Author(s):  
Simone Fulda ◽  
Klaus-Michael Debatin
Keyword(s):  
Apoptosis Pathways

Development of a Primary Testicular Tumour during Surveillance for Testicular Microlithiasis

Ultrasound ◽  
2009 ◽  
Vol 17 (3) ◽  
pp. 156-158 ◽  
Author(s):  
Iheoma Amaechi ◽  
Mohammed Z Khan ◽  
Paul S Sidhu
Keyword(s):  
Risk Factors ◽  
Management Strategy ◽  
Testicular Tumour ◽  
Surveillance Program ◽  
Testicular Microlithiasis

We describe a case of the development of a testicular tumour in a patient with unilateral limited testicular microlithiasis after five years on a follow-up surveillance program. We discuss the risk factors for the development of a testicular tumour, review the literature, and suggest a management strategy for follow-up of patients with testicular microlithiasis.

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