scholarly journals Elevated seminal protein carbonyl concentration is correlated with asthenozoospermia and affects adversely the laboratory intracytoplasmic sperm injection (ICSI) outcomes

Andrologia ◽  
2021 ◽  
Author(s):  
Mohammad A Al Smadi ◽  
Mohamad Eid Hammadeh ◽  
Osamah Batiha ◽  
Emad Al Sharu ◽  
Mohammad M Altalib ◽  
...  
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Protein Carbonyl ◽  
Icsi Outcomes

scholarly journals Comparison of intracytoplasmic sperm injection (ICSI) outcomes in infertile men with spermatogenic impairment of differing severity

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Xiang-Feng Chen ◽  
Ping Ping ◽  
Zhong Zheng ◽  
Yi Ma ◽  
Sha-Sha Zou
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Infertile Men ◽  
Icsi Outcomes

O-224 Paternal ageing impacts blastulation and pregnancy outcomes at different levels of maternal age: a clustering analysis of 21,960 injected oocytes and 3837 ICSI cycles

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
A Setti ◽  
D Braga ◽  
P Guilherme ◽  
L Vingris ◽  
A Iaconelli ◽  
...  
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Pregnancy Outcomes ◽  
Maternal Age ◽  
Implantation Rate ◽  
Paternal Age ◽  
Independent Variable ◽  
Interaction Term ◽  
Icsi Outcomes ◽  
Main Effects

Abstract Study question Are the morphological parameters and development of in vitro cultured embryos, and intracytoplasmic sperm injection (ICSI) outcomes influenced by maternal and paternal ageing? Summary answer The slopes of maternal age on blastulation, blastocyst quality, and implantation, pregnancy and miscarriage rates significantly changed (worsened) for every year increase in paternal age. What is known already Due to the vast literature demonstrating that female age interferes with intracytoplasmic sperm injection (ICSI) outcomes, there is an imposition, in numerous countries, regarding maternal age limit for assisted reproduction. Despite several studies have underscored the negative impact of paternal age and lifestyle factors on reproductive health, the influence of paternal age on ICSI outcomes is still a matter of debate. The aim of this study was to investigate if the effect of paternal age on embryo development differs at different values of maternal age, thus creating a rationale for the data to reach physicians, patients, and public health recommendations. Study design, size, duration This historical cohort study included 3837 couples undergoing their first ICSI cycle from January/2014 to October/2020. A total of 21960 oocytes were injected and embryos were evaluated until day 5 of development. The main effects of maternal and paternal ages, as well as the effect of their product (interaction term) on embryo growth and development, and on pregnancy outcomes were investigated taking into account clustering of data (multiple embryos per cycle), using generalized mixed models. Participants/materials, setting, methods The study was performed in a private university-affiliated in vitro fertilization center. Zygotes were morphologically evaluated 17h post ICSI. For days 2 and 3 of development, the number of blastomeres, blastomere symmetry, percentage of fragmentation and presence of multinucleation were recorded. On day 5 of development, successful blastulation, and inner cell mass and trophectoderm qualities were recorded. Pregnancy was calculated per transfer, and miscarriage was defined as pregnancy loss before 20 weeks gestation. Main results and the role of chance The coefficients for the interaction term were statistically significant for blastocyst development (B: - 0.005, OR: 0.995, CI: 0.994 – 0.996, p < 0.001), top-quality blastocyst (B: - 0.003, OR: 0.997, CI: 0.996 – 0.999, p < 0.001), implantation rate (B: - 0.041, OR: 0.960, CI: 0.947 – 0.973, p < 0.001), pregnancy rate (B: - 0.004, OR: 0.996, CI: 0.995 – 0.997, p < 0.001), and miscarriage rate (B: 0.011, OR: 1.012, CI: 1.005 – 1.018, p = 0.001). These values describe the changes in slopes such that, the slope of one independent variable (e.g. maternal age) on the dependent variable (e.g. implantation rate) changes by the value of B (- 0.041) for every unit change on the other independent variable (e.g. paternal age). No significant results were observed for the influence of the interaction term on embryo morphological features on days 1, 2 and 3 of development. Two post hoc power analyses were calculated, given α of 5%, sample size of 21960 zygotes and 3315 ICSI cycles with embryo transfer and effect sizes for blastulation and pregnancy outcomes, respectively. The achieved power was superior to 99% in both analyses. Limitations, reasons for caution The retrospective and monocentric nature of the study are its major limitations. Wider implications of the findings Our results underscore the importance of both maternal and paternal ages for blastulation and successful pregnancy. Main effects of paternal and maternal ages should no longer be interpreted as the relationship between each independent variable and a given outcome, but rather be conditional on the values of the interaction term. Trial registration number Not applicable

scholarly journals Overcoming male factor infertility with intracytoplasmic sperm injection

2017 ◽  
Vol 63 (8) ◽  
pp. 697-703 ◽  
Author(s):  
Edson Borges Jr. ◽  
Bianca Ferrarini Zanetti ◽  
Daniela Paes de Almeida Ferreira Braga ◽  
Amanda Souza Setti ◽  
Rita de Cássia Sávio Figueira ◽  
...  
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Maternal Age ◽  
Age Groups ◽  
Control Group ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Vitro Fertilization ◽  
Tubal Factor ◽  
Icsi Outcomes

Summary Objective: To evaluate the effect of male factor infertility on intracytoplasmic sperm injection (ICSI) outcomes compared with a control group presenting isolated tubal factor. Method: This retrospective study included 743 couples undergoing ICSI as a result of isolated male factor and a control group consisting of 179 couples undergoing ICSI as a result of isolated tubal factor, performed in a private university- -affiliated in vitro fertilization center, between January/2010 and December/2016. Patients were divided into two groups according to maternal age: women ≤35 years old and >35 years old. The effects of infertility causes on laboratorial and clinical ICSI outcomes were evaluated using Student's t-test and (2 test. Results: No differences in controlled ovarian stimulation outcomes were observed between male factor cycles and tubal factor cycles in the two age groups. Implantation (male factor 35.5% vs. tubal factor 32.0%, p=0.340), pregnancy (male factor 46.9% vs. tubal factor 40.9%, p=0.184) and miscarriage (male factor 10.3% vs. tubal factor 10.6%, p=0.572) rates were similar between the infertility groups, irrespective of female age. Considering maternal age, the cancelation rate was higher in older women (>35 years old) undergoing ICSI as a result of male factor infertility (17.4% vs. 8.9%, p=0.013). Conclusion: Our results showed that there is no difference in the outcomes of pregnancy between couples with male or tubal factor infertility, which indicates that ICSI surpasses the worse specific outcomes associated with male factor.

scholarly journals Impact of advanced paternal age on the intracytoplasmic sperm injection (ICSI) outcomes in donor egg cycles

2019 ◽  
Vol 8 (S1) ◽  
pp. S22-S30 ◽  
Author(s):  
Gianmartin Cito ◽  
Maria Elisabetta Coccia ◽  
Rita Picone ◽  
Andrea Cocci ◽  
Giorgio Ivan Russo ◽  
...  
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Paternal Age ◽  
Advanced Paternal Age ◽  
Icsi Outcomes ◽  
Donor Egg

scholarly journals PD34-05 SPERM RETRIEVAL AND INTRACYTOPLASMIC SPERM INJECTION (ICSI) OUTCOMES IN MEN WITH CYSTIC FIBROSIS (CF) DISEASE VERSUS CONGENITAL BILATERAL ABSENCE OF THE VAS DEFERENS (CBAVD)

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
J. Abram McBride* ◽  
Taylor Kohn ◽  
Sukhkamal Campbell ◽  
Jabez Gondokusomo ◽  
Alex Tatem ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Intracytoplasmic Sperm Injection ◽  
Vas Deferens ◽  
Sperm Retrieval ◽  
Bilateral Absence ◽  
Icsi Outcomes

Obesity and increased body fat composition significantly affect intracytoplasmic sperm injection (ICSI) outcomes

2008 ◽  
Vol 90 ◽  
pp. S468-S469
Author(s):  
A.F. Galal ◽  
D.N. Elhelaly ◽  
F. Elsahn ◽  
H.A. Saleh
Keyword(s):  
Body Fat ◽  
Intracytoplasmic Sperm Injection ◽  
Fat Composition ◽  
Icsi Outcomes
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