scholarly journals Evaluation of the novel vaginal contraceptive agent PPCM in preclinical studies using sperm hyaluronan binding and acrosome status assays

Andrology ◽  
2021 ◽  
Author(s):  
B.B. North ◽  
M.B. Weitzel ◽  
D.P. Waller ◽  
W.X. Birch ◽  
K. A. Feathergill ◽  
...  
Keyword(s):  
Preclinical Studies ◽  
The Novel ◽  
Contraceptive Agent ◽  
Hyaluronan Binding

Characterization and Biodistribution of the Novel A1-Adenosine Receptor Antagonist [18F]CPFPX: Preclinical Studies Using Autoradioraphy and PET

NeuroImage ◽  
1998 ◽  
Vol 7 (4) ◽  
pp. A3
Author(s):  
M. Holschbach ◽  
C. Boy ◽  
H. Mühlensiepen ◽  
H. Herzog ◽  
J. Shah ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Adenosine Receptor ◽  
Preclinical Studies ◽  
The Novel ◽  
A1 Adenosine Receptor ◽  
Adenosine Receptor Antagonist

scholarly journals Preclinical Studies on the Mechanism of Action and the Anti-Lymphoma Activity of the Novel Anti-CD20 Antibody GA101

2011 ◽  
Vol 10 (1) ◽  
pp. 178-185 ◽  
Author(s):  
Stephane Dalle ◽  
Lina Reslan ◽  
Timothee Besseyre de Horts ◽  
Stephanie Herveau ◽  
Frank Herting ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Preclinical Studies ◽  
The Novel ◽  
Cd20 Antibody ◽  
Anti Cd20

scholarly journals MicroencapsulatedBifidobacterium longumsubsp.infantisATCC 15697 Favorably Modulates Gut Microbiota and Reduces Circulating Endotoxins in F344 Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Laetitia Rodes ◽  
Shyamali Saha ◽  
Catherine Tomaro-Duchesneau ◽  
Satya Prakash
Keyword(s):  
Gut Microbiota ◽  
Human Health ◽  
Liver Diseases ◽  
Saline Control ◽  
Preclinical Studies ◽  
The Novel ◽  
Bifidobacterium Infantis ◽  
F344 Rats ◽  
Metabolic Endotoxemia

The gut microbiota is a bacterial bioreactor whose composition is an asset for human health. However, circulating gut microbiota derived endotoxins cause metabolic endotoxemia, promoting metabolic and liver diseases. This study investigates the potential of orally delivered microencapsulatedBifidobacterium infantisATCC 15697 to modulate the gut microbiota and reduce endotoxemia in F344 rats. The rats were gavaged daily with saline or microencapsulatedB. infantisATCC 15697. Following 38 days of supplementation, the treated rats showed a significant (P< 0.05) increase in fecalBifidobacteria(4.34 ± 0.46 versus 2.45 ± 0.25% of total) andB. infantis(0.28 ± 0.21 versus 0.52 ± 0.12 % of total) and a significant (P< 0.05) decrease in fecal Enterobacteriaceae (0.80 ± 0.45 versus 2.83 ± 0.63% of total) compared to the saline control. In addition, supplementation with the probiotic formulation reduced fecal (10.52 ± 0.18 versus 11.29 ± 0.16 EU/mg;P= 0.01) and serum (0.33 ± 0.015 versus 0.30 ± 0.015 EU/mL;P= 0.25) endotoxins. Thus, microencapsulatedB. infantisATCC 15697 modulates the gut microbiota and reduces colonic and serum endotoxins. Future preclinical studies should investigate the potential of the novel probiotic formulation in metabolic and liver diseases.

scholarly journals Moving beyond hydroxychloroquine: the novel lysosomal autophagy inhibitor ROC-325 shows significant potential in preclinical studies

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Trace M. Jones ◽  
Claudia Espitia ◽  
Wei Wang ◽  
Steffan T. Nawrocki ◽  
Jennifer S. Carew
Keyword(s):  
Preclinical Studies ◽  
The Novel ◽  
Significant Potential ◽  
Autophagy Inhibitor

Unravelling The Immune Modulatory Effect Of Indian Spices To Impede The Transmission Of Covid-19: A Promising Approach

2021 ◽  
Vol 22 ◽  
Author(s):  
Aswathy R Devan ◽  
Bhagyalakshmi Nair ◽  
Ayana R Kumar ◽  
Jaggaiah N Gorantla Gorantla ◽  
T. S. Aishwarya ◽  
...  
Keyword(s):  
Public Health ◽  
Herbal Medicines ◽  
Public Health Emergency ◽  
Effective Vaccine ◽  
Preclinical Studies ◽  
The Novel ◽  
Global Public Health ◽  
Excellent Safety Profile ◽  
Safety And Toxicity ◽  
Novel Coronavirus

: Months after WHO declared COVID-19 as a Global Public Health Emergency of International Concern, it does not seem to be flattening the curve as we are still devoid of an effective vaccine and treatment modality. Amid such uncertainty, being immune is the best strategy to defend against corona attack. As the whole world is referring back to immune-boosting grandma remedies, interest is rekindled in the Indian system of Medicine, which is gifted with an abundance of herbal medicines as well as remedies. Among them, spices (root, rhizome, seed, fruit, leaf, bud, and flower of various plants used to add taste and flavors to food) are bestowed with immense medicinal potential. A plethora of clinical as well as preclinical studies reported the effectiveness of various spices for various ailments. The potential immune-boosting properties together with its excellent safety profile are making spices the current choice of Phyto-research as well as the immune-boosting home remedies during these sceptical times. The present review critically evaluates the immune impact of various Indian spices and their potential to tackle the novel coronavirus, with comments on the safety and toxicity aspects of spices.

The novel steroidal glycoside from the dried bulb of Allium Macrostemon Bunge inhibits platelet activation

2010 ◽  
Vol 34 (8) ◽  
pp. S33-S33
Author(s):  
Wenchao Ou ◽  
Haifeng Chen ◽  
Yun Zhong ◽  
Benrong Liu ◽  
Keji Chen
Keyword(s):  
Platelet Activation ◽  
The Novel ◽  
Steroidal Glycoside ◽  
Allium Macrostemon

The novel histamine H2 receptor antagonist FRG-8813 prevents delay of wound repair induced by hydrogen peroxide in a rabbit gastric epithelial cell system

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S209-S213
Author(s):  
NOBUHIRO SATO ◽  
SUMIO WATANABE ◽  
XIAN-EN WANG ◽  
TARO OSADA ◽  
HIROSHI TANAKA ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Epithelial Cell ◽  
Receptor Antagonist ◽  
Wound Repair ◽  
Cell System ◽  
The Novel ◽  
H2 Receptor Antagonist ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Histamine H2 Receptor Antagonist

1444: Functional Effect of the Novel Rho-Kinase Inhibitor H-1152 in the Erectile Machinery

2004 ◽  
Vol 171 (4S) ◽  
pp. 380-380
Author(s):  
Cleber E. Teixeira ◽  
R. Clinton Webb
Keyword(s):  
Kinase Inhibitor ◽  
Rho Kinase ◽  
The Novel ◽  
Functional Effect ◽  
Rho Kinase Inhibitor
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