scholarly journals Metformin serum concentrations during pregnancy and postpartum – a clinical study in patients with polycystic ovary syndrome

2021 ◽  
Author(s):  
Ketil Arne Espnes ◽  
Arne Hønnås ◽  
Tone S. Løvvik ◽  
Per Ole M. Gundersen ◽  
Audhild Naavik ◽  
...  
Keyword(s):  
Clinical Study ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Concentrations ◽  
Ovary Syndrome ◽  
Pregnancy And Postpartum

Increased Anti-Müllerian Hormone Serum Concentrations during Late Reproductive Age in Women with Polycystic Ovary Syndrome

2011 ◽  
pp. P2-232-P2-232
Author(s):  
Teresa Sir-Petermann ◽  
Amanda Ladron de Guevara ◽  
Jessica Preisler ◽  
Barbara Echiburu ◽  
Manuel Maliqueo ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Serum Concentrations ◽  
Ovary Syndrome

The impact of metformin treatment on adiponectin and resistin levels in women with polycystic ovary syndrome: a prospective clinical study

2014 ◽  
Vol 31 (2) ◽  
pp. 136-140 ◽  
Author(s):  
G. Basios ◽  
E. Trakakis ◽  
Ch. Chrelias ◽  
P. Panagopoulos ◽  
V. Vaggopoulos ◽  
...  
Keyword(s):  
Clinical Study ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Prospective Clinical Study ◽  
Metformin Treatment ◽  
Ovary Syndrome ◽  
The Impact

Lipid profile in nonobese pregnant women with polycystic ovary syndrome: A prospective controlled clinical study

Steroids ◽  
2014 ◽  
Vol 88 ◽  
pp. 36-43 ◽  
Author(s):  
Stefano Palomba ◽  
Angela Falbo ◽  
Giuseppe Chiossi ◽  
Giovanna Muscogiuri ◽  
Eleonora Fornaciari ◽  
...  
Keyword(s):  
Clinical Study ◽  
Polycystic Ovary Syndrome ◽  
Pregnant Women ◽  
Lipid Profile ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Controlled Clinical Study

scholarly journals Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome

2014 ◽  
Vol 12 (1) ◽  
pp. 88 ◽  
Author(s):  
Beata Seeber ◽  
Elisabeth Morandell ◽  
Fabian Lunger ◽  
Ludwig Wildt ◽  
Hans Dieplinger
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Concentrations ◽  
Ovary Syndrome

L-Carnitine improves endocrine function and folliculogenesis by reducing inflammation, oxidative stress and apoptosis in mice following induction of polycystic ovary syndrome

2019 ◽  
Vol 31 (2) ◽  
pp. 282 ◽  
Author(s):  
Zahra Kalhori ◽  
Malek Soleimani Mehranjani ◽  
Mehri Azadbakht ◽  
Mohammad Ali Shariatzadeh
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Endocrine Function ◽  
Serum Concentrations ◽  
Ovary Syndrome ◽  
Antioxidant Power ◽  
Tnf Α ◽  
Pcos Group ◽  
Necrosis Factor ◽  
Group Serum

Polycystic ovary syndrome (PCOS) is related to low levels of serum l-carnitine, which has antioxidant, anti-inflammatory and antiapoptotic properties. The aim of this study was to investigate the effect of l-carnitine on folliculogenesis in mice following induction of PCOS. PCOS was induced by daily injections of testosterone enanthate (1mg per 100g, s.c., for 35 days). NMRI mice (21 days old) were divided into four groups (n=6 per group): Control, Control+l-carnitine, PCOS and PCOS+l-carnitine. Mice were treated with 500mgkg−1, i.p., l-carnitine every second day for 28 days. Ovaries were studied stereologically and serum concentrations of FSH, LH, testosterone, interleukin (IL)-6 and tumour necrosis factor (TNF)-α were determined using ELISA kits. Serum concentrations of malondialdehyde (MDA) and the ferric ion reducing antioxidant power (FRAP) were also analysed. Apoptosis of follicles was evaluated by terminal deoxyribonucleotidyl transferase-mediated dUTP–digoxigenin nick end-labelling (TUNEL). CD31 was assessed immunohistochemically. Data were analysed using one-way analysis of variance (ANOVA) and Tukey’s test, differences considered significant at P<0.05.The total volume of the ovary, cortex volume, oocyte volume, zona pellucida thickness and the number of antral follicles increased significantly, whereas the number of primary and preantral follicles decreased significantly, in the PCOS+l-carnitine versus PCOS group. In the PCOS+l-carnitine group, serum concentrations of FSH and FRAP increased significantly, whereas there were significant decreases in serum concentrations of testosterone, LH, MDA, IL-6 and TNF-α, as well as in the percentage of TUNEL-positive apoptotic cells, compared with the PCOS group. l-Carnitine improves folliculogenesis and is therefore suggested as a therapeutic supplement in the treatment of PCOS.

scholarly journals Serum inhibin B in polycystic ovary syndrome as a potential marker of ovarian dysfunction

2008 ◽  
Vol 136 (7-8) ◽  
pp. 379-383
Author(s):  
Aleksandar Cetkovic
Keyword(s):  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Inhibin B ◽  
Control Group ◽  
Serum Concentrations ◽  
Ovarian Dysfunction ◽  
Ovary Syndrome ◽  
The Third ◽  
Healthy Women

INTRODUCTION Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulation, infertility and hyperandrogenism, and the prevalence of this condition in women of reproductive is 5-10%. The growth of early ovarian antral follicles is arrested and dominant follicle selection is disturbed in this syndrome. OBJECTIVE The aim of this study is to investigate whether inhibin B serum concentrations represent the extent of ovarian abnormalities in patients with PCOS. METHOD Inhibin B serum concentrations on the third day of spontaneous menstrual cycle and other endocrine characteristics were compared between 20 patients with PCOS and 19 healthy women in the control group. RESULTS Inhibin B concentrations were not significantly different between women with PCOS and women in the control group. In patients with PCOS there was statistically significant correlation between serum inhibin B and LH (r=0.514; p=0.021). There were no positive correlations between inhibin B and others endocrine parameters in patients with PCOS (FSH, E2, T, androstenedione). CONCLUSION Inhibin B serum concentrations on the third day of spontaneous menstrual cycle in women with PCOS are not different from the concentrations in healthy women. Serum Inhibin B levels in patients with PCOS are only slightly correlated with the endocrine markers of the disease so it could not represent the magnitude of ovarian dysfunction in this syndrome.

scholarly journals Body Composition, Serum Concentrations of Androgens and Insulin Resistance in Different Polycystic Ovary Syndrome Phenotypes

2020 ◽  
Vol 9 (3) ◽  
pp. 732 ◽  
Author(s):  
Aleksandra Maria Polak ◽  
Agnieszka Adamska ◽  
Anna Krentowska ◽  
Agnieszka Łebkowska ◽  
Justyna Hryniewicka ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Control Group ◽  
Model Assessment ◽  
Serum Concentrations ◽  
Metabolic Disturbances ◽  
Ovary Syndrome ◽  
G Ratio

Insulin resistance and hyperandrogenemia observed in polycystic ovary syndrome (PCOS) are associated with metabolic disturbances and could be connected with body composition pattern. To date, several studies defining the parameters of body composition using dual energy X-ray absorptiometry (DXA) method in the group of PCOS patients have been published, however, without the analysis in different phenotypes. The aim of the present study was to investigate the relationships between serum androgens concentration, insulin resistance and distribution of fat mass using DXA method in various PCOS phenotypes according to the Rotterdam criteria. We examined 146 women: 34 (38%) had PCOS phenotype A, 20 (23%) phenotype B, 20 (23%) phenotype C and 15 (16%) phenotype D (with mean age of each phenotype 25 years), and 57 control subjects (mean age of 25.5 years). Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Serum concentrations of testosterone, androstenedione and dehydroepiandrosterone sulfate (DHEA-S) were assessed and free androgen index (FAI) was calculated. In phenotypes A, B and C, we observed higher FAI in comparison to the control group (all p < 0.01). Serum concentrations of androstenedione and DHEA-S were higher in phenotypes A and C in comparison to the control group (all p < 0.01). However, only in phenotype A we found higher visceral adipose tissue (VAT) mass and android/gynoid ratio (A/G ratio) in comparison to the control group (all p < 0.01). In phenotype A, we observed connection of VAT with FAI (r = 0.58, p < 0.01). Accordingly, A/G ratio was related with FAI in all phenotypes (all p < 0.05). Additionally, in phenotype C, A/G ratio was related to serum concentrations of DHEA-S and androstenedione (r = 0.46, p = 0.03; r = 0.53, p = 0.01, respectively). We also found connections of HOMA-IR with VAT and A/G ratio in all phenotypes (all p < 0.05). Women with phenotype A had higher amount of VAT and A/G ratio in comparison to the control group. Serum concentration of androgens and insulin resistance are connected with VAT and A/G ratio in normoandrogenic and hyperandrogenic PCOS phenotypes.

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