Mitochondrial DNA damage as a biomarker for ultraviolet radiation exposure and oxidative stress

2013 ◽  
Vol 169 ◽  
pp. 9-14 ◽  
Author(s):  
M.A. Birch-Machin ◽  
E.V. Russell ◽  
J.A. Latimer
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Ultraviolet Radiation ◽  
Radiation Exposure ◽  
Mitochondrial Dna Damage ◽  
Ultraviolet Radiation Exposure ◽  
And Oxidative Stress

scholarly journals Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys

2012 ◽  
Vol 47 (1) ◽  
pp. 29-37 ◽  
Author(s):  
María del R. Castro ◽  
Edu Suarez ◽  
Edmundo Kraiselburd ◽  
Angel Isidro ◽  
José Paz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Rhesus Monkeys ◽  
Mitochondrial Dna Damage ◽  
And Oxidative Stress

scholarly journals Oxidative Stress and Mitochondrial DNA Damage in Heart Failure

2008 ◽  
Vol 72 (SupplementA) ◽  
pp. A31-A37 ◽  
Author(s):  
Hiroyuki Tsutsui ◽  
Shintaro Kinugawa ◽  
Shouji Matsushima
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Mitochondrial Dna Damage

scholarly journals Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction

2001 ◽  
Vol 88 (5) ◽  
pp. 529-535 ◽  
Author(s):  
Tomomi Ide ◽  
Hiroyuki Tsutsui ◽  
Shunji Hayashidani ◽  
Dongchon Kang ◽  
Nobuhiro Suematsu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Mitochondrial Dna Damage

Detection of oxidative stress-induced mitochondrial DNA damage using fluorescence correlation spectroscopy

2006 ◽  
Vol 350 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Yasutomo Nomura ◽  
Hirobumi Fuchigami ◽  
Hiroaki Kii ◽  
Zhonggang Feng ◽  
Takao Nakamura ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Fluorescence Correlation Spectroscopy ◽  
Correlation Spectroscopy ◽  
Fluorescence Correlation ◽  
Mitochondrial Dna Damage

scholarly journals Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Uraiwan Panich ◽  
Gunya Sittithumcharee ◽  
Natwarath Rathviboon ◽  
Siwanon Jirawatnotai
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Dna Damage ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Ultraviolet Radiation ◽  
Skin Aging ◽  
The Body ◽  
And Oxidative Stress

Skin is the largest human organ. Skin continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. Some areas of skin are continuously exposed to a variety of environmental stressors that can inflict direct and indirect damage to skin cell DNA. Skin homeostasis is maintained by mesenchymal stem cells in inner layer dermis and epidermal stem cells (ESCs) in the outer layer epidermis. Reduction of skin stem cell number and function has been linked to impaired skin homeostasis (e.g., skin premature aging and skin cancers). Skin stem cells, with self-renewal capability and multipotency, are frequently affected by environment. Ultraviolet radiation (UVR), a major cause of stem cell DNA damage, can contribute to depletion of stem cells (ESCs and mesenchymal stem cells) and damage of stem cell niche, eventually leading to photoinduced skin aging. In this review, we discuss the role of UV-induced DNA damage and oxidative stress in the skin stem cell aging in order to gain insights into the pathogenesis and develop a way to reduce photoaging of skin cells.

scholarly journals Oxidative Stress Mediates Tumor Necrosis Factor-α–Induced Mitochondrial DNA Damage and Dysfunction in Cardiac Myocytes

Circulation ◽  
2003 ◽  
Vol 107 (10) ◽  
pp. 1418-1423 ◽  
Author(s):  
Nobuhiro Suematsu ◽  
Hiroyuki Tsutsui ◽  
Jing Wen ◽  
Dongchon Kang ◽  
Masaki Ikeuchi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Tumor Necrosis Factor ◽  
Cardiac Myocytes ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Mitochondrial Dna Damage ◽  
Factor Α ◽  
Necrosis Factor
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