Human papillomavirus evaluation of vemurafenib-induced skin epithelial tumors: a case series

2014 ◽  
Vol 172 (2) ◽  
pp. 540-542 ◽  
Author(s):  
E. Dika ◽  
A. Patrizi ◽  
S. Venturoli ◽  
P.A. Fanti ◽  
D. Barbieri ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Case Series ◽  
Epithelial Tumors

Human papillomavirus lesions in 16 MS patients treated with fingolimod: Outcomes and vaccination

2021 ◽  
pp. 135245852199143
Author(s):  
Elsa Mhanna ◽  
Agathe Nouchi ◽  
Céline Louapre ◽  
Raphael De Paz ◽  
Olivier Heinzlef ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Human Papillomavirus ◽  
Hpv Vaccination ◽  
Case Series ◽  
Good Tolerance ◽  
Prevalence Studies ◽  
Disease Modifying Therapies ◽  
Disease Modifying ◽  
Hpv Screening

Few cases of human papillomavirus (HPV) diseases have been reported in multiple sclerosis (MS) patients treated with fingolimod. We describe a case series of 16 MS patients (11 women, 5 men) developing HPV lesions after the onset of fingolimod, without previous HPV history. Fingolimod had to be discontinued in six patients. Six patients received vaccination for HPV, with good tolerance. Our report highlights that systematic HPV screening and discussion about HPV vaccination before fingolimod onset are crucial. In case of occurrence of HPV lesions during fingolimod treatment, a comprehensive workup of HPV disease is necessary, with discussion of HPV vaccination to prevent secondary lesions. Prevalence studies of HPV lesions are needed in MS patients with the different disease-modifying therapies.

scholarly journals Human Papillomavirus–Associated Oropharyngeal High-Grade Neuroendocrine Carcinoma in an Adolescent: Case Report and Review of Literature

2019 ◽  
Vol 13 ◽  
pp. 117955651987052 ◽  
Author(s):  
Sara Sinno ◽  
Adel M Assaad ◽  
Nina Salem Shabb
Keyword(s):  
Human Papillomavirus ◽  
Case Reports ◽  
Case Series ◽  
Hpv Infection ◽  
Small Cell ◽  
Squamous Cell Carcinomas ◽  
High Grade ◽  
Review Of Literature ◽  
Squamous Differentiation ◽  
Tonsillar Carcinoma

Oropharyngeal small cell carcinomas (OPSmCC) are rare with only few case reports and case series published in the literature. More recently, an association of these tumors with human papillomavirus (HPV) infection has been detected. However, unlike oropharyngeal squamous cell carcinomas which have a better outcome when associated with HPV, OPSmCC exhibit an aggressive behavior. In this article, we report a case of tonsillar carcinoma arising in a 14-year-old boy that was associated with HPV infection. The tumor exhibited morphologic features of small cell carcinoma with no overt squamous differentiation. Yet, by immunohistochemistry, it showed diffuse and strong co-expression of both squamous and neuroendocrine markers. In addition, we present the clinicopathologic features of all the cases of OPSmCC reported in the literature for which p16 and/or HPV testing have been done.

scholarly journals Hospital Records of Pain, Fatigue, or Circulatory Symptoms in Girls Exposed to Human Papillomavirus Vaccination: Cohort, Self-Controlled Case Series, and Population Time Trend Studies

2020 ◽  
Vol 189 (4) ◽  
pp. 277-285 ◽  
Author(s):  
Reimar Wernich Thomsen ◽  
Buket Öztürk ◽  
Lars Pedersen ◽  
Sia Kromann Nicolaisen ◽  
Irene Petersen ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hpv Vaccine ◽  
Time Trend ◽  
Hpv Vaccination ◽  
Case Series ◽  
Public Confidence ◽  
Postural Orthostatic Tachycardia Syndrome ◽  
Hospital Records ◽  
Trend Analyses ◽  
Increased Risk

Abstract Human papillomavirus (HPV) vaccination has been associated with subsequent diffuse symptoms in girls, reducing public confidence in the vaccine. We examined whether girls have nonspecific outcomes of HPV vaccination, using triangulation from cohort, self-controlled case series (SCCS), and population time trend analyses carried out in Denmark between 2000 and 2014. The study population consisted of 314,017 HPV-vaccinated girls and 314,017 age-matched HPV-unvaccinated girls (cohort analyses); 11,817 girls with hospital records (SCCS analyses); and 1,465,049 girls and boys (population time trend analyses). The main outcome measures were hospital records of pain, fatigue, or circulatory symptoms. The cohort study revealed no increased risk among HPV vaccine-exposed girls, with incidence rate ratios close to 1.0 for abdominal pain, nonspecific pain, headache, hypotension/syncope, tachycardia (including postural orthostatic tachycardia syndrome), and malaise/fatigue (including chronic fatigue syndrome). In the SCCS analyses, we observed no association between HPV vaccination and subsequent symptoms. In time trend analyses, we observed a steady increase in these hospital records in both girls and (HPV-unvaccinated) boys, with no relationship to the 2009 introduction of HPV vaccine to Denmark’s vaccination program. This study, which had nationwide coverage, showed no evidence of a causal link between HPV vaccination and diffuse autonomic symptoms leading to hospital contact.

scholarly journals Oral Human Papillomavirus Infection and Head and Neck Squamous Cell Carcinoma in Rural Northwest Cameroon

OTO Open ◽  
2019 ◽  
Vol 3 (1) ◽  
pp. 2473974X1881841
Author(s):  
Eleni M. Rettig ◽  
Zhen Gooi ◽  
Richard Bardin ◽  
Mesele Bogale ◽  
Lisa Rooper ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Squamous Cell ◽  
Case Series ◽  
Hpv Infection ◽  
Future Research ◽  
Retrospective Case ◽  
Cross Sectional ◽  
Study Population ◽  
Oral Hpv ◽  
Hpv Types

Objective Oral human papillomavirus (HPV) infection is the precursor for a growing subset of oropharyngeal squamous cell carcinomas (OPSCCs) in the developed world. This study was designed to characterize oral HPV infection and OPSCC in a region with high rates of HPV-driven cervical cancer. Study Design Cross-sectional cohort study, retrospective case series. Setting Northwest Cameroon referral hospital. Subjects and Methods Individuals infected with human immunodeficiency virus attending an outpatient clinic were evaluated for oral HPV infection with oral swabs or rinses that were tested for 51 HPV types. HNSCCs diagnosed and/or treated at the same hospital from 2011 to 2017 were retrospectively reviewed to ascertain demographic and tumor characteristics, and available OPSCCs were tested for HPV. Results The oral HPV infection study population comprised 101 participants. Most (69%) were female and never-smokers (84%). Participants had median 4 lifetime sexual partners (interquartile range, 3-7; range, 1-100). Five participants (5%) had oral HPV infection; one had 2 HPV types. HPV types detected were HPV68 (n = 2), HPV82 (n = 2), HPV32 (n = 1), and unknown (n = 1). No significant demographic or behavioral differences were detected among individuals with vs without oral HPV infection. OPSCCs comprised just 8% (n = 11) of 131 HNSCCs in the retrospective study population. Two of 7 OPSCCs were HPV positive. Conclusion The low prevalence of OPSCC observed in northwest Cameroon together with the rarity of oral HPV infection suggests low rates of HPV-driven oropharyngeal carcinogenesis in the region. Future research should examine how geographic differences in oral HPV infection are influenced by cultural norms and affect HPV-OPSCC epidemiology.

scholarly journals Human papillomavirus in skin tags: a case series

2018 ◽  
pp. 295-296
Author(s):  
Caterina Dianzani ◽  
Francesca Paolini ◽  
Claudio Conforti ◽  
Maria Silvestre ◽  
Francesca Flagiello ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Case Series ◽  
Skin Tags

Topical cidofovir for benign human papillomavirus–associated skin lesions

2021 ◽  
pp. 135965352110598
Author(s):  
Larry Napolitano ◽  
Liesl Schroedl ◽  
Alexander Kerman ◽  
Christopher R Shea
Keyword(s):  
Human Papillomavirus ◽  
Treatment Option ◽  
Successful Treatment ◽  
Broad Spectrum ◽  
Immune Status ◽  
Response Rate ◽  
Topical Therapy ◽  
Case Series ◽  
Antiviral Agent ◽  
Skin Lesions

Cidofovir is a broad-spectrum antiviral agent that has shown efficacy against skin lesions caused by human papillomavirus (HPV). We present a case of extensive verruca vulgaris lesions refractory to imiquimod that was responsive to topical cidofovir therapy, and analyze other case series in the literature of successful treatment of benign HPV-associated skin lesions with topical cidofovir. Topical cidofovir’s favorable response rate and tolerability make it a useful treatment option for patients of differing ages and immune status who have nonmalignant HPV-associated skin lesions and desire topical therapy.

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