scholarly journals The ‘Chronic Itch Burden Scale’: giving patients with chronic pruritus a voice

2021 ◽  
Author(s):  
M. Gabes
Keyword(s):  
Chronic Itch ◽  
Burden Scale ◽  
Chronic Pruritus

scholarly journals Mirtazapine for the Treatment of Chronic Pruritus

Medicines ◽  
2019 ◽  
Vol 6 (3) ◽  
pp. 73 ◽  
Author(s):  
Raveena Khanna ◽  
Emily Boozalis ◽  
Micah Belzberg ◽  
John G. Zampella ◽  
Shawn G. Kwatra
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Conventional Therapy ◽  
Sleep Disturbances ◽  
English Language ◽  
First Line ◽  
Chronic Itch ◽  
Wide Range ◽  
Chronic Pruritus

Background: Chronic pruritus is a debilitating condition associated with a wide range of dermatologic, systemic and psychogenic etiologies. In patients with chronic pruritus that is refractory to conventional therapy, symptoms can significantly decrease quality of life by contributing to anxiety, sleep disturbances, and in many cases depression. Recent studies have demonstrated the effectiveness of mirtazapine in relieving chronic itch that is refractory to standard first-line therapies. Methods: We searched PubMed for English-language articles containing the words (“pruritus” or “itch”) AND “antidepressant” and then conducted a systematic review of the current literature to summarize the efficacy of mirtazapine in treating chronic itch. Results: All studies reported a reduction in itch intensity following the administration of mirtazapine. Conclusion: Collectively, these studies suggest the potential for mirtazapine to relieve chronic itch attributed to dermatological causes and malignancies. As, such mirtazapine may be an option for patients with chronic pruritus that is refractory to typical first-line treatments.

scholarly journals Microglia are Involved in Pruritus Induced by DNFB via the CX3CR1/p38 MAPK Pathway

2015 ◽  
Vol 35 (3) ◽  
pp. 1023-1033 ◽  
Author(s):  
Ying Zhang ◽  
Jia Yan ◽  
Rong Hu ◽  
Yu Sun ◽  
Yiwen Ma ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Intrathecal Administration ◽  
P38 Inhibitor ◽  
P38 Mapk Pathway ◽  
Chronic Itch ◽  
Repeated Applications ◽  
Chronic Pruritus

Background/Aims: Pruritus, also known as itch, is a common, unpleasant sensation that can be difficult to treat. Frequently, chronic itch is associated with the development of neuropathic pain resulting from nerve injury or insult. Previous studies have shown the involvement of spinal microglia in the development of neuropathic pain, but their role in chronic pruritus is unclear. Methods: For this study, we constructed a model of chronic pruritus in mice using repeated applications of 2, 4-dinitrofluorobenzene (DNFB) and showed prolonged scratching behavior in treated mice that continued for at least 7 d after the final DNFB treatment. Results: Scratching was accompanied by activation of spinal microglia and both were reduced by an inhibitor of microglial activity. We also showed that microglial activation entailed increased signaling in the p38 MAPK pathway, and treatment with a p38 inhibitor reduced scratching in DNFB-treated mice. We also examined the role of fractalkine/CX3CR1 signaling in the development of DNFB-induced pruritus and showed that intrathecal administration of antiserum against either CX3CR1or FKN inhibited p38 activity and decreased scratching. Conclusion: Our results suggest that microglia are involved in pruritus induced by DNFB via FKN/CX3CR1/p38MAPK pathways similar to those participating in the development of neuropathic pain.

scholarly journals Prurigo nodularis, prurigo chronica, new therapeutic options

2021 ◽  
Vol 97 (5) ◽  
pp. 274-277
Author(s):  
Zsuzsanna Bata-Csörgő ◽  
Keyword(s):  
Skin Disease ◽  
Therapeutic Targets ◽  
Therapeutic Options ◽  
The Novel ◽  
Novel Therapies ◽  
Prurigo Nodularis ◽  
Intensive Research ◽  
Chronic Itch ◽  
Chronic Pruritus ◽  
Opening Up

Prurigo nodularis (PN) is a skin disease that develops on chronically itchy skin. There are various causes behind the chronic itch. Due to intensive research in recent years different mechanisms that can participate in the development of chronic pruritus have been discovered, opening up new therapeutic targets for treatment. Here we review the various mechanisms behind chronic pruritus and discuss the novel therapies for PN.

scholarly journals Breaking the Itch–Scratch Cycle: Topical Options for the Management of Chronic Cutaneous Itch in Atopic Dermatitis

Medicines ◽  
2019 ◽  
Vol 6 (3) ◽  
pp. 76 ◽  
Author(s):  
Ian P. Harrison ◽  
Fabrizio Spada
Keyword(s):  
Atopic Dermatitis ◽  
Treatment Options ◽  
Calcineurin Inhibitors ◽  
Cost Of Treatment ◽  
Topical Calcineurin Inhibitors ◽  
Chronic Itch ◽  
Itch Sensation ◽  
Chronic Pruritus

Chronic itch is an unpleasant sensation that triggers a desire to scratch that lasts for six weeks or more. It is a major diagnostic symptom of myriad diseases, including atopic dermatitis for which it is the most prominent feature. Chronic itch can be hugely debilitating for the sufferer, damaging in terms of both the monetary cost of treatment and its socioeconomic effects, and few treatment options exist that can adequately control it. Corticosteroids remain the first line treatment strategy for atopic dermatitis, but due to the risks associated with long-term use of corticosteroids, and the drawbacks of other topical options such as topical calcineurin inhibitors and capsaicin, topical options for itch management that are efficacious and can be used indefinitely are needed. In this review, we detail the pathophysiology of chronic pruritus, its key features, and the disease most commonly associated with it. We also assess the role of the skin and its components in maintaining a healthy barrier function, thus reducing dryness and the itch sensation. Lastly, we briefly detail examples of topical options for the management of chronic pruritus that can be used indefinitely, overcoming the risk associated with long-term use of corticosteroids.

Un nouvel autoquestionnaire pour évaluer le prurit chronique « The Chronic Itch Burden Scale »

2020 ◽  
Vol 147 (12) ◽  
pp. A258
Author(s):  
J. Theunis ◽  
C. Nordon ◽  
N. Morisot ◽  
B. Falissard ◽  
M. Auges ◽  
...  
Keyword(s):  
Chronic Itch ◽  
Burden Scale

Pruritus

2014 ◽  
Author(s):  
Hong-Liang Tey ◽  
Gil Yosipovitch ◽  
Jeffrey D Bernhard
Keyword(s):  
Treatment Options ◽  
Clinical Signs ◽  
Calcineurin Inhibitors ◽  
Clinical Findings ◽  
Screening Tests ◽  
Topical Calcineurin Inhibitors ◽  
Chronic Itch ◽  
Chronic Pruritus ◽  
Systemic Therapies

Pruritus, or itch, can be defined as a sensation that elicits the desire to scratch. Normal physiologic "acute" itch occurs daily and can usually be abolished by scratching the affected area. On the other hand, chronic itch (defined as itch that persists for 6 weeks or more) is often made worse by scratching and is associated with significant morbidity. The focus of this chapter is on chronic pruritus. Discussion includes causes, clinical evaluation, investigation of, and treatment for chronic pruritus. Tables cover the etiologic classification of chronic pruritus, a morphologic approach to typically pruritic dermatoses and their classic distribution (with illustrative images), systemic diseases and associated clinical signs, localized pruritus and underlying neuropathy, screening tests for pruritus, further investigations following results of clinical findings and screening tests, general measures for patients managing pruritus, topical treatment, topical calcineurin inhibitors, systemic therapies, recommended stepwise treatment options, and phototherapy. Also included are a patient history checklist, an algorithm outlining the approach to chronic pruritus, and images depicting various forms of pruritus. This review contains 16 highly rendered figures (including table images), 13 tables, and 41 references.

Pruritus

2014 ◽  
Author(s):  
Hong-Liang Tey ◽  
Gil Yosipovitch ◽  
Jeffrey D Bernhard
Keyword(s):  
Treatment Options ◽  
Clinical Signs ◽  
Calcineurin Inhibitors ◽  
Clinical Findings ◽  
Screening Tests ◽  
Topical Calcineurin Inhibitors ◽  
Chronic Itch ◽  
Chronic Pruritus ◽  
Systemic Therapies

Pruritus, or itch, can be defined as a sensation that elicits the desire to scratch. Normal physiologic "acute" itch occurs daily and can usually be abolished by scratching the affected area. On the other hand, chronic itch (defined as itch that persists for 6 weeks or more) is often made worse by scratching and is associated with significant morbidity. The focus of this chapter is on chronic pruritus. Discussion includes causes, clinical evaluation, investigation of, and treatment for chronic pruritus. Tables cover the etiologic classification of chronic pruritus, a morphologic approach to typically pruritic dermatoses and their classic distribution (with illustrative images), systemic diseases and associated clinical signs, localized pruritus and underlying neuropathy, screening tests for pruritus, further investigations following results of clinical findings and screening tests, general measures for patients managing pruritus, topical treatment, topical calcineurin inhibitors, systemic therapies, recommended stepwise treatment options, and phototherapy. Also included are a patient history checklist, an algorithm outlining the approach to chronic pruritus, and images depicting various forms of pruritus. This review contains 16 highly rendered figures (including table images), 13 tables, and 41 references.

scholarly journals Pruriplastic Itch—A Novel Pathogenic Concept in Chronic Pruritus

2021 ◽  
Vol 7 ◽  
Author(s):  
Laurent Misery
Keyword(s):  
International Association ◽  
Somatosensory System ◽  
Pruritus Ani ◽  
Sensitive Skin ◽  
Systematic Screening ◽  
Tailored Treatment ◽  
Chronic Itch ◽  
Chronic Pruritus ◽  
Definition Of ◽  
Somatosensory Nervous System

The International Association for the Study of Pain (IASP) defined three descriptors for pain: nociceptive pain is “pain that arises from actual or threatened damage to non neural tissue and is due to the activation of nociceptors”; neuropathic pain is “pain caused by a lesion or disease of the somatosensory nervous system”; and nociplastic pain is “pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain.” Based on clinical and pathophysiological arguments, a similar definition of “pruriplastic pruritus” should be made. Pruriplastic pruritus would include psychogenic pruritus, as well as some cases of pruritus ani, vulvar pruritus, sensitive skin or other poorly understood cases of pruritus. This new descriptor of itch could serve as systematic screening for altered pruriceptive function in patients who suffer from chronic itch and it may also help in defining better tailored treatment by identifying patients who are likely to respond better to centrally rather than to peripherally targeted therapies.

Chronic Itch: Research on Mechanisms Leads to Novel Therapies

2006 ◽  
Vol 39 (3) ◽  
pp. 15
Author(s):  
BETSY BATES
Keyword(s):  
Novel Therapies ◽  
Chronic Itch
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