scholarly journals Pruriplastic Itch—A Novel Pathogenic Concept in Chronic Pruritus

2021 ◽  
Vol 7 ◽  
Author(s):  
Laurent Misery

The International Association for the Study of Pain (IASP) defined three descriptors for pain: nociceptive pain is “pain that arises from actual or threatened damage to non neural tissue and is due to the activation of nociceptors”; neuropathic pain is “pain caused by a lesion or disease of the somatosensory nervous system”; and nociplastic pain is “pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain.” Based on clinical and pathophysiological arguments, a similar definition of “pruriplastic pruritus” should be made. Pruriplastic pruritus would include psychogenic pruritus, as well as some cases of pruritus ani, vulvar pruritus, sensitive skin or other poorly understood cases of pruritus. This new descriptor of itch could serve as systematic screening for altered pruriceptive function in patients who suffer from chronic itch and it may also help in defining better tailored treatment by identifying patients who are likely to respond better to centrally rather than to peripherally targeted therapies.

Cosmetics ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 66
Author(s):  
Vito Rizzi ◽  
Jennifer Gubitosa ◽  
Paola Fini ◽  
Pinalysa Cosma

The “modern” cosmetology industry is focusing on research devoted to discovering novel neurocosmetic functional ingredients that could improve the interactions between the skin and the nervous system. Many cosmetic companies have started to formulate neurocosmetic products that exhibit their activity on the cutaneous nervous system by affecting the skin’s neuromediators through different mechanisms of action. This review aims to clarify the definition of neurocosmetics, and to describe the features of some functional ingredients and products available on the market, with a look at the regulatory aspect. The attention is devoted to neurocosmetic ingredients for combating skin stress, explaining the stress pathways, which are also correlated with skin aging. “Neuro-relaxing” anti-aging ingredients derived from plant extracts and neurocosmetic strategies to combat inflammatory responses related to skin stress are presented. Afterwards, the molecular basis of sensitive skin and the suitable neurocosmetic ingredients to improve this problem are discussed. With the aim of presenting the major application of Botox-like ingredients as the first neurocosmetics on the market, skin aging is also introduced, and its theory is presented. To confirm the efficacy of the cosmetic products on the market, the concept of cosmetic claims is discussed.


2021 ◽  
Vol 95 (9) ◽  
Author(s):  
Jaakko Mäkinen

AbstractThe International Height Reference System (IHRS), adopted by International Association of Geodesy (IAG) in its Resolution No. 1 at the XXVI General Assembly of the International Union of Geodesy and Geophysics (IUGG) in Prague in 2015, contains two novelties. Firstly, the mean-tide concept is adopted for handling the permanent tide. While many national height systems continue to apply the mean-tide concept, this was the first time that the IAG officially introduced it for a potential field quantity. Secondly, the reference level of the height system is defined by the equipotential surface where the geopotential has a conventional value W0 = 62,636,853.4 m2 s–2. This value was first determined empirically to provide a good approximation to the global mean sea level and then adopted as a reference value by convention. I analyse the tidal aspects of the reference level based on W0. By definition, W0 is independent of the tidal concept that was adopted for the equipotential surface, but for different concepts, different functions are involved in the W of the equation W = W0. I find that, in the empirical determination of the adopted estimate W0, the permanent tide is treated inconsistently. However, the consistent estimate from the same data rounds off to the same value. I discuss the tidal conventions and formulas for the International Height Reference Frame (IHRF) and the realisation of the IHRS. I propose a simplified definition of IHRF geopotential numbers that would make it possible to transform between the IHRF and zero-tide geopotential numbers using a simple datum-difference surface. Such a transformation would not be adequate if rigorous mean-tide formulas were imposed. The IHRF should adopt a conventional (best) estimate of the permanent tide-generating potential, such as that which is contained in the International Earth Rotation and Reference Systems Service Conventions, and use it as a basis for other conventional formulas. The tide-free coordinates of the International Terrestrial Reference Frame and tide-free Global Geopotential Models are central in the modelling of geopotential for the purposes of the IHRF. I present a set of correction formulas that can be used to move to the zero-tide model before, during, or after the processing, and finally to the mean-tide IHRF. To reduce the confusion around the multitude of tidal concepts, I propose that modelling should primarily be done using the zero-tide concept, with the mean-tide potential as an add-on. The widespread use of the expression “systems of permanent tide” may also have contributed to the confusion, as such “systems” do not have the properties that are generally associated with other “systems” in geodesy. Hence, this paper mostly uses “concept” instead of “system” when referring to the permanent tide.


The chapter covers the notions of illiteracy, literacy, and their development to the current moment. The authors present the notion of functional literacy specified by the UNESCO experts. A more detailed definition of functional literacy is to be found in the study Progress in International Reading Literacy Study (PIRLS). It is possible to perceive the reader's literacy based on age or different planes. The chapter contains information about research focused on the age: PIRLS handled by IEA (International Association for the Evaluation of Educational Achievement) and the PISA research organized by The Organisation for Economic Co-operation and Development (OECD). Both kinds of research focus on the reader's literacy and their authors provide their own definitions that differ based on age. There are various different approaches to increase the attractiveness of reading. The authors introduce at least some of them as an inspiration. One part is dedicated to the development of reader literacy in individuals with dyslexia.


Medicines ◽  
2019 ◽  
Vol 6 (3) ◽  
pp. 73 ◽  
Author(s):  
Raveena Khanna ◽  
Emily Boozalis ◽  
Micah Belzberg ◽  
John G. Zampella ◽  
Shawn G. Kwatra

Background: Chronic pruritus is a debilitating condition associated with a wide range of dermatologic, systemic and psychogenic etiologies. In patients with chronic pruritus that is refractory to conventional therapy, symptoms can significantly decrease quality of life by contributing to anxiety, sleep disturbances, and in many cases depression. Recent studies have demonstrated the effectiveness of mirtazapine in relieving chronic itch that is refractory to standard first-line therapies. Methods: We searched PubMed for English-language articles containing the words (“pruritus” or “itch”) AND “antidepressant” and then conducted a systematic review of the current literature to summarize the efficacy of mirtazapine in treating chronic itch. Results: All studies reported a reduction in itch intensity following the administration of mirtazapine. Conclusion: Collectively, these studies suggest the potential for mirtazapine to relieve chronic itch attributed to dermatological causes and malignancies. As, such mirtazapine may be an option for patients with chronic pruritus that is refractory to typical first-line treatments.


2020 ◽  
Vol 23 (4) ◽  
pp. 451-471
Author(s):  
Michael D. White

Over the last few years, there has been a series of high-profile, premeditated ambush attacks on police, which has led some to conclude there is a “war on cops.” Unfortunately, prior research has not examined the prevalence of police ambushes over an extended period of time, and the most recent study only analyzed the phenomenon through 2013. Moreover, the “war on cops” thesis implies a very specific motivation for an ambush: hatred of police or desire to seek vengeance in response to police killings of citizens. Prior research has not sufficiently explored the motivations of ambush attacks, or whether recent trends in ambushes are linked to a “war on cops” motive. I investigate ambush killings of police from 1970 to 2018 using data from the Officer Down Memorial Page in an attempt to address these research gaps. I apply a temporal coding scheme of when the attack occurred to isolate killings of police that are consistent with the International Association of Chiefs of Police definition of an ambush. Results from linear regression show that the annual rates of ambush killings of police have declined by more than 90% since 1970. Although ambushes spiked in 2016 and 2018 to the highest rates in 20 years, interrupted time series analysis indicates no statistically significant increase post-2013. Spikes have also occurred in nonambush killings since 2014. Police leaders and researchers should monitor trends in ambush and nonambush killings of police, as the recent spikes may presage the emergence of a chronic problem.


PAIN Reports ◽  
2018 ◽  
Vol 3 (2) ◽  
pp. e634 ◽  
Author(s):  
Milton Cohen ◽  
John Quintner ◽  
Simon van Rysewyk

2020 ◽  
Vol 18 (4) ◽  
pp. 5
Author(s):  
N.N. Yakhno ◽  
M.L. Kukushkin ◽  
M.V. Churyukanov ◽  
O.S. Davydov ◽  
M.A. Bakhtadze

Author(s):  
Elżbieta Skorupska

Nowadays, there are three main pain descriptors: nociceptive pain, neuropathic pain, and nociplastic pain. The last one is the newest expression defining pain as ‘Pain that arises from altered nociception, despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain’ (International Association for the Study of Pain). The implementation of modern pain neuroscience in practice is said to be the most important for musculoskeletal physical therapists around the world. One of the examples of the nociplastic pain mechanism can be myofascial trigger points that are connected with central sensitization (one of the subtypes of nociplastic pain). Central sensitization (CS) is defined as an amplification of neural signaling within the central nervous system that elicits pain hypersensitivity and ongoing neuronal excitation which outlasts the initial nociceptor input. Features typical of that state are abnormally low peripheral thresholds for pain from pressure, temperature, electrical, and other stimuli and it has been proposed that trigger points may function as peripheral mediators of CS.


2017 ◽  
Author(s):  
Marina Rubio

Five international organisations cooperated in the project ‘Groundwater Governance: A Global Framework for Action’ (2011-2016): Global Environment Fund (GEF), Food and Agriculture Organization of the United Nations (FAO), United Nations Economic, Social and Cultural Organization International Hydrological Program (UNESCO IHP), International Association of Hydrogeologists (IAH) The present document presents the Vision resulting of a consultative process and the definition of ‘Groundwater Governance’ and its components. It provides a synthetic overview of the enabling frameworks and guiding principles of the Framework for Action prepared by the project. Conscious of the need to raise political awareness at global level and to act with urgency to improve groundwater governance, the five institutions make an urgent call to action if trends in the state of this resource are to be reversed. Governance Groundwater


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