Bone metastases in germ cell tumours: lessons learnt from a large retrospective study

2013 ◽  
Vol 112 (2) ◽  
pp. 176-181 ◽  
Author(s):  
Mariam Jamal-Hanjani ◽  
Anna Karpathakis ◽  
Amy Kwan ◽  
Danish Mazhar ◽  
Wendy Ansell ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Germ Cell ◽  
Bone Metastases ◽  
Germ Cell Tumours ◽  
Lessons Learnt ◽  
Large Retrospective Study

scholarly journals SURVIVAL IMPACT OF SKELETAL METASTASIS ON BONE SCINTIGRAPHY IN PATIENTS WITH GERM CELL TUMOURS

2016 ◽  
Vol 2 (4) ◽  
Author(s):  
Maimoona Siddique ◽  
Aamna Hassan ◽  
Saadiya J Khan
Keyword(s):  
Germ Cell ◽  
Bone Metastases ◽  
Bone Scintigraphy ◽  
Bone Scan ◽  
Disease Free Survival ◽  
Skeletal Metastasis ◽  
Whole Body ◽  
Skeletal Metastases ◽  
Germ Cell Tumours ◽  
Visceral Metastases

Objective: Our aim was to determine the frequency of skeletal metastasis in germ cell tumours (GCT) at baseline and relapse on conventional technetium-99m methylene diphosphonate (Tc-99m MDP) whole body bone scan (bone scan) and to evaluate the effect of bone metastases on survival. Materials and Methods: Electronic medical records of histologically proven GCT over 64 months were retrospectively analysed. Basic demographic and histologic information were correlated with the presence of osseous and visceral metastases. 5-year disease-free survival (DFS) and overall survival (OS) were calculated in presence, the absence of bone metastases at baseline and at relapse. Results: A total of 130 gonadal and extragonadal GCT patients underwent Tc-99m MDP bone scans; four with insuf cient data were excluded from the study. 47% were females and 53% were males with the age range of 1 month – 72 years. 105 (83%) were under 18 years of age. Osseous metastasis was detected in 12 (9.5%). Two (17%) had solitary and 10 (83%) had multifocal skeletal metastases. Clinically, 83% had localised bone pain. Osseous metastases were more frequently associated with mixed GCT and yolk sac tumour. 50% of mediastinal GCT developed bone metastases. 42% died within 4–18 months. There was a statistically signi cant impact of visceral metastases on DFS and OS. OS at 5 years in patients without bone metastases, with bone metastases at baseline and bone metastases at relapse, was 77%, 38% and 75%, respectively. 5-year DFS for the same cohort groups was 63%, 38% and 20%, respectively. Conclusion: Osseous involvement was found in 9.5% of GCT patients undergoing diagnostic Tc-99m MDP bone scan. Baseline skeletal evaluation for metastases should be done, particularly in the case of bone pains or known systemic metastases. Although skeletal relapses are rare, they have a grim outcome. Key words: Bone scintigraphy, germ cell tumours, skeletal metastases 

scholarly journals Incidence of malignant mixed ovarian germ cell tumours in a tertiary care hospital: A five year retrospective study

2020 ◽  
Vol 6 (4) ◽  
Author(s):  
Emilio M Treviño-Salinas ◽  
Karen A Pinto-García ◽  
José G Garza-Leal ◽  
Oralia Barboza-Quintana ◽  
Gabriela García-Tamez ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Germ Cell ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Germ Cell Tumours

scholarly journals Primary central nervous system germ cell tumours: A single institution retrospective study

2017 ◽  
Vol 28 ◽  
pp. v120
Author(s):  
J.P. Silva ◽  
M. Ramos ◽  
A. Azevedo ◽  
D. Salgado ◽  
I. Costa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Study ◽  
Germ Cell ◽  
Germ Cell Tumours ◽  
Single Institution

scholarly journals Clinico-pathological spectrum of testicular and paratesticular lesions: a retrospective study

2018 ◽  
Vol 6 (9) ◽  
pp. 3120
Author(s):  
Annu Charak ◽  
Irfan Ahmed ◽  
Bushra Rashid Sahaf ◽  
Rehana Qadir ◽  
A. R. Rather
Keyword(s):  
Retrospective Study ◽  
Germ Cell ◽  
Undescended Testis ◽  
Age Distribution ◽  
Testicular Descent ◽  
Testicular Neoplasm ◽  
Germ Cell Tumours ◽  
Scrotal Swelling ◽  
Testicular Lesions ◽  
Yolk Sac Tumour

Background: Both neoplastic and non neoplastic conditions affect the testis. Although non neoplastic testicular lesions are more common, still most of the studies were done on testicular neoplasms only. Hence the present study was undertaken to study histopathological spectrum of testicular and paratesticular lesions, their age distribution and clinical presentation.Methods: This is a retrospective study of 77 cases of orchidectomy specimens, testicular biopsies and paratesticular lesions received in the department from Jan 2015 to June 2018.Results: Non neoplastic testicular lesions were more common than neoplastic (90.1% Vs 9.8%) with majority in the second and third decade. Undescended testis comprised 46.1% of the total orchidectomy specimens followed by Torsion/Infarction testis (15.3%). None of the undescended testis showed tumour unlike western countries. Majority of patients presented with empty scrotum (31.16%) and testicular/scrotal swelling (18.11%). Only 5 cases of testicular neoplasm were diagnosed during the study period amounting to only 1.42 cases per year. All were germ cell tumours (4 classic seminoma and 1 yolk sac tumour).Conclusions: Non neoplastic testicular lesions were more common than neoplastic lesions. Complete neonatal examination for testicular descent should be mandatory to avoid late presentations and future malignancies. Germ cell tumours formed the bulk of testicular tumours.

Bone metastases in germ cell tumours: Surgical management and outcomes

2017 ◽  
Vol 16 (3) ◽  
pp. e1903-e1904
Author(s):  
A. Nini ◽  
M. Konieczny ◽  
C. Winter ◽  
A. Lusch ◽  
R. Krauspe ◽  
...  
Keyword(s):  
Germ Cell ◽  
Bone Metastases ◽  
Surgical Management ◽  
Germ Cell Tumours

scholarly journals The Potential of Artificial Intelligence to Detect Lymphovascular Invasion in Testicular Cancer

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1325
Author(s):  
Abhisek Ghosh ◽  
Korsuk Sirinukunwattana ◽  
Nasullah Khalid Alham ◽  
Lisa Browning ◽  
Richard Colling ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Testicular Cancer ◽  
Germ Cell ◽  
Lymphovascular Invasion ◽  
Automatic Segmentation ◽  
Prognostic Significance ◽  
Germ Cell Tumours ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Tumours ◽  
Whole Slide Images

Testicular cancer is the most common cancer in men aged from 15 to 34 years. Lymphovascular invasion refers to the presence of tumours within endothelial-lined lymphatic or vascular channels, and has been shown to have prognostic significance in testicular germ cell tumours. In non-seminomatous tumours, lymphovascular invasion is the most powerful prognostic factor for stage 1 disease. For the pathologist, searching multiple slides for lymphovascular invasion can be highly time-consuming. The aim of this retrospective study was to develop and assess an artificial intelligence algorithm that can identify areas suspicious for lymphovascular invasion in histological digital whole slide images. Areas of possible lymphovascular invasion were annotated in a total of 184 whole slide images of haematoxylin and eosin (H&E) stained tissue from 19 patients with testicular germ cell tumours, including a mixture of seminoma and non-seminomatous cases. Following consensus review by specialist uropathologists, we trained a deep learning classifier for automatic segmentation of areas suspicious for lymphovascular invasion. The classifier identified 34 areas within a validation set of 118 whole slide images from 10 patients, each of which was reviewed by three expert pathologists to form a majority consensus. The precision was 0.68 for areas which were considered to be appropriate to flag, and 0.56 for areas considered to be definite lymphovascular invasion. An artificial intelligence tool which highlights areas of possible lymphovascular invasion to reporting pathologists, who then make a final judgement on its presence or absence, has been demonstrated as feasible in this proof-of-concept study. Further development is required before clinical deployment.

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