Endocytosis and stress: From mechanisms to cellular physiology

2021 ◽  
Author(s):  
Sébastien Léon
Keyword(s):  
Cellular Physiology

Nanoparticle-plasma Membrane Interactions: Thermodynamics, Toxicity and Cellular Response

2020 ◽  
Vol 27 (20) ◽  
pp. 3330-3345
Author(s):  
Ana G. Rodríguez-Hernández ◽  
Rafael Vazquez-Duhalt ◽  
Alejandro Huerta-Saquero
Keyword(s):  
Gene Expression ◽  
Immune Responses ◽  
Cellular Response ◽  
Cellular Level ◽  
Membrane Interactions ◽  
Daily Lives ◽  
Cellular Physiology ◽  
Associated Proteins ◽  
First Contact ◽  
Insight Into

Nanomaterials have become part of our daily lives, particularly nanoparticles contained in food, water, cosmetics, additives and textiles. Nanoparticles interact with organisms at the cellular level. The cell membrane is the first protective barrier against the potential toxic effect of nanoparticles. This first contact, including the interaction between the cell membranes -and associated proteins- and the nanoparticles is critically reviewed here. Nanoparticles, depending on their toxicity, can cause cellular physiology alterations, such as a disruption in cell signaling or changes in gene expression and they can trigger immune responses and even apoptosis. Additionally, the fundamental thermodynamics behind the nanoparticle-membrane and nanoparticle-proteins-membrane interactions are discussed. The analysis is intended to increase our insight into the mechanisms involved in these interactions. Finally, consequences are reviewed and discussed.

Effects of Crosstalks Between Sumoylation and Phosphorylation in Normal Cellular Physiology and Human Diseases

2017 ◽  
Vol 16 (10) ◽  
pp. 906-913 ◽  
Author(s):  
Q. Nie ◽  
X.-D. Gong ◽  
M. Liu ◽  
D. Li
Keyword(s):  
Human Diseases ◽  
Cellular Physiology

scholarly journals JCP anniversary issue: Seventy-five years of milestones in cellular physiology

2007 ◽  
Vol 213 (2) ◽  
pp. 285-285
Author(s):  
Gary S. Stein ◽  
Constance E. Brinckerhoff ◽  
Harvey M. Florman
Keyword(s):  
Cellular Physiology ◽  
Anniversary Issue

Unraveling the cerebellar cortex: cytology and cellular physiology of large-sized interneurons in the granular layer

2003 ◽  
Vol 2 (4) ◽  
pp. 290-299 ◽  
Author(s):  
Frederik Geurts ◽  
Erik De Schutter ◽  
Stéphane Dieudonné
Keyword(s):  
Cerebellar Cortex ◽  
Granular Layer ◽  
Cellular Physiology

scholarly journals ON THE CHANGES INDUCED IN BLOOD BY FEEDING: A STUDY IN CELLULAR PHYSIOLOGY.

The Lancet ◽  
1912 ◽  
Vol 180 (4651) ◽  
pp. 1069-1073
Author(s):  
Gustav Mann ◽  
JohnG Gage
Keyword(s):  
Cellular Physiology

scholarly journals Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae

2013 ◽  
Vol 42 (5) ◽  
pp. 3246-3260 ◽  
Author(s):  
Sunny Sharma ◽  
Jun Yang ◽  
Simon Düttmann ◽  
Peter Watzinger ◽  
Peter Kötter ◽  
...  
Keyword(s):  
Large Subunit ◽  
Point Mutations ◽  
Binding Pocket ◽  
Phenotypic Characterization ◽  
Deletion Mutants ◽  
Chemical Modifications ◽  
Gene Complementation ◽  
Cellular Physiology ◽  
Complex Processes ◽  
Rp Hplc

Abstract RNA contains various chemical modifications that expand its otherwise limited repertoire to mediate complex processes like translation and gene regulation. 25S rRNA of the large subunit of ribosome contains eight base methylations. Except for the methylation of uridine residues, methyltransferases for all other known base methylations have been recently identified. Here we report the identification of BMT5 (YIL096C) and BMT6 (YLR063W), two previously uncharacterized genes, to be responsible for m3U2634 and m3U2843 methylation of the 25S rRNA, respectively. These genes were identified by RP-HPLC screening of all deletion mutants of putative RNA methyltransferases and were confirmed by gene complementation and phenotypic characterization. Both proteins belong to Rossmann-fold–like methyltransferases and the point mutations in the S-adenosyl-l-methionine binding pocket abolish the methylation reaction. Bmt5 localizes in the nucleolus, whereas Bmt6 is localized predominantly in the cytoplasm. Furthermore, we showed that 25S rRNA of yeast does not contain any m5U residues as previously predicted. With Bmt5 and Bmt6, all base methyltransferases of the 25S rRNA have been identified. This will facilitate the analyses of the significance of these modifications in ribosome function and cellular physiology.

scholarly journals Jan Evangelista Purkinje (1797-1869)

2021 ◽  
Vol 11 (22) ◽  
pp. 81-85
Author(s):  
Tamás Fazekas
Keyword(s):  
Middle Layer ◽  
Conduction System ◽  
Cardiac Conduction ◽  
Animal Tissues ◽  
Basic Principles ◽  
Cellular Physiology ◽  
Medical Language ◽  
Physical Chemical ◽  
Claude Bernard ◽  
The World

Being a chairman and professor of physiology in Breslau/Wroclaw till 1850, Jan Evangelista Purkinje (1797-1869) made many crucial discoveries/experiments with the new advanced microscopy and histology techniques. He established the first institute of the physiology of the world (1839) and founded the basic principles and framework of cellular physiology (protoplasmic concept) both in plant and animal tissues. Purkine discovered and described (first in Polish, 1839) the extensive terminal network of the cardiac conduction system. Its paradigmatic discovery was presented in the last two 15-page German article in 1845, which was immediately translated into English by Sir William Withey Gull (1816-1880), an extraordinary physician to the queen and Prince of Wales. In 1837, he made his other famous discovery of Purkine cells, a giant flak-shaped nerve cell forming the middle layer of the cerebellum. His combination of physical, chemical, and microscopic observations made him the father of modern experimental physiology and predecessor of the legendary French scientist/biologist, Claude Bernard (1813-1878). Purkinje as a Czech and Slav patriot advocated cultural collaboration of Slav nations and promoted understanding between the nations of the Habsburg monarchy. His life and personality is also an inspiration on how to be a truly humanistic European and yet, a highly responsible, convinced patriot. He was a pioneer of the Czech medical language. His achievements are possibly best documented by this rhyme of Goethe: „…and should you fail to understand let Purkinje give you a hand.” True also for our times (cit by Zarsky).

Sign in / Sign up

Export Citation Format

Share Document