Anti‐inflammatory effects of α7‐nicotinic ACh receptors are exerted through interactions with adenylyl cyclase‐6

2021 ◽  
Author(s):  
Simeng Zhu ◽  
Shiqian Huang ◽  
Guofang Xia ◽  
Jin Wu ◽  
Yan Shen ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Anti Inflammatory ◽  
Ach Receptors

scholarly journals Anti-inflammatory effects of CHRNA7 through interacting with adenylyl cyclase 6

2020 ◽  
Author(s):  
Simeng Zhu ◽  
Shiqian Huang ◽  
Guofang Xia ◽  
Jin Wu ◽  
Yan Shen ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Anti Inflammatory

Postischemic anti-inflammatory effects of ethanol preconditioning (EPC) are initiated by adenylyl cyclase/protein kinase a activation

2003 ◽  
Vol 124 (4) ◽  
pp. A147
Author(s):  
Kazuhiro Kamada ◽  
Taiji Yamaguchi ◽  
Toshikazu Yoshikawa ◽  
Ronald J. Korthuis
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Adenylyl Cyclase ◽  
Anti Inflammatory ◽  
Ethanol Preconditioning ◽  
Kinase A

Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies

2020 ◽  
Vol 134 (17) ◽  
pp. 2243-2262
Author(s):  
Danlin Liu ◽  
Gavin Richardson ◽  
Fehmi M. Benli ◽  
Catherine Park ◽  
João V. de Souza ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Nlrp3 Inflammasome ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Therapeutic Interventions ◽  
Low Grade ◽  
Cardiovascular Research ◽  
Inflammatory Processes ◽  
Ach Receptors

Abstract In the elderly population, pathological inflammation has been associated with ageing-associated diseases. The term ‘inflammageing’, which was used for the first time by Franceschi and co-workers in 2000, is associated with the chronic, low-grade, subclinical inflammatory processes coupled to biological ageing. The source of these inflammatory processes is debated. The senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammageing. The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD+ metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh receptors; and modulation by senolytics targeting other proteins have gained a lot of interest within cardiovascular research and drug development communities. In this review, which offers a unique view from both clinical and preclinical target-based drug discovery perspectives, we have focused on cardiovascular inflammageing and its molecular mechanisms. We have outlined the mechanistic links between inflammageing, SASP, interleukin (IL)-1β, NLRP3 inflammasome, nicotinic ACh receptors, and molecular targets of senolytic drugs in the context of cardiovascular diseases. We have addressed the ‘druggability’ of NLRP3 and nicotinic α7 receptors by small molecules, as these proteins represent novel and exciting targets for therapeutic interventions targeting inflammageing in the cardiovascular system and beyond.

Ultraviolet irradiation-induced inflammation: effects of steroid and nonsteroid anti-inflammatory agents

1979 ◽  
Vol 115 (12) ◽  
pp. 1421-1423 ◽  
Author(s):  
W. H. Eaglestein
Keyword(s):  
Ultraviolet Irradiation ◽  
Anti Inflammatory

Nonsteroidal anti-inflammatory drug-induced gastrointestinal injury

1996 ◽  
Vol 101 (1) ◽  
pp. S25-S32 ◽  
Author(s):  
D BJORKMAN
Keyword(s):  
Drug Induced ◽  
Inflammatory Drug ◽  
Gastrointestinal Injury ◽  
Anti Inflammatory

Does eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy reduce the long-term risk of ulcers? A double-blinded randomized trial

2001 ◽  
Vol 120 (5) ◽  
pp. A143-A143
Author(s):  
F CHAN ◽  
K TO ◽  
J WU ◽  
W LEUNG ◽  
Y LEE ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Drug Therapy ◽  
Randomized Trial ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Double Blinded

758: Inflammatory and Anti-Inflammatory Regulators alter Levels of an Inhibitor of Apoptosis (IAP), Survivin, in T-24 Bladder Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 254-254
Author(s):  
Justin J. Cohen ◽  
Bayan T. Takizawa ◽  
Hristos Z. Kaimkliotis ◽  
David J. Rosenberg ◽  
Marcia A. Wheeler ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Inhibitor Of Apoptosis ◽  
Bladder Cancer Cells ◽  
Anti Inflammatory

1216: Oral Treatment with a Vitamin D3 Analogue Shows Anti Inflammatory Effects and Reduces Bladder Overactivity in Rodent Models of Chronic Cystitis

2005 ◽  
Vol 173 (4S) ◽  
pp. 330-330
Author(s):  
Peter Zvara ◽  
Fabio Benigni ◽  
Enrico Baroni ◽  
Marija Zecevic ◽  
Antonia Monno ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Oral Treatment ◽  
Rodent Models ◽  
Chronic Cystitis ◽  
Anti Inflammatory
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