scholarly journals Diverse roles of microbial indole compounds in eukaryotic systems

2021 ◽  
Author(s):  
Prasun Kumar ◽  
Jin‐Hyung Lee ◽  
Jintae Lee
Keyword(s):  
Indole Compounds

scholarly journals Enzymatic reactions in teleocidin B biosynthesis

2021 ◽  
Author(s):  
Takayoshi Awakawa
Keyword(s):  
Structural Biology ◽  
Bond Formation ◽  
Enzymatic Reactions ◽  
New Developments ◽  
Indole Compounds ◽  
Kinase C ◽  
Biological Studies ◽  
New Knowledge ◽  
Primary Focus ◽  
Activate Protein Kinase

AbstractThe teleocidin B family members are terpene indole compounds isolated from Streptomyces bacteria, and they strongly activate protein kinase C (PKC). Their unique structures have attracted many researchers in the natural product chemistry and pharmacology fields, and numerous isolation and bioactivity studies have been conducted. The accumulated information has facilitated the identification of the enzymatic reactions in teleocidin biosynthesis, and new developments in structural biology have strongly aided efforts to clarify the finer points of these reactions. This review describes the recent biochemical and structural biological studies to reveal their reaction mechanisms, with a primary focus on the terpene cyclization triggered by the C-N bond formation by P450 oxygenase (TleB), the prenyltransferase (TleC), and the methyltransferase (TleD). This new knowledge will benefit future engineering studies to create unnatural PKC activators.

scholarly journals Engineered RebH halogenase variants demonstrating a specificity switch from tryptophan towards novel indole compounds

ChemBioChem ◽  
2021 ◽  
Author(s):  
Barindra Sana ◽  
Timothy Ho ◽  
Srinivasaraghavan Kannan ◽  
Ding Ke ◽  
Eunice Li ◽  
...  
Keyword(s):  
Indole Compounds

scholarly journals Physiologically Active Compounds in Four Species of Phellinus

2017 ◽  
Vol 12 (3) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Katarzyna Sułkowska-Ziaja ◽  
Anna Maślanka ◽  
Agnieszka Szewczyk ◽  
Bożena Muszyńska
Keyword(s):  
Phenolic Acids ◽  
High Performance ◽  
Total Content ◽  
Dry Weight ◽  
Hplc Method ◽  
Indole Compounds ◽  
Methanolic Extracts ◽  
Free Phenolic Acids ◽  
Layer Chromatography ◽  
Physiologically Active Compounds

The content of two groups of compounds with biological activity (non-hallucinogenic indole compounds and free phenolic acids) were analyzed in extracts of fruiting bodies of four species of Phellinus: P. igniarius, P. pini, P. pomaceus and P. robustus. The presence of indole compounds in methanolic extracts was analyzed by high-performance liquid chromatography and thin-layer chromatography coupled with densitometric detection. Three metabolites (serotonin, tryptamine, and L-tryptophan) were identified. The contents of individual indole compounds ranged from 1.70 (tryptamine in P. robustus) to 8.32 mg x 100 g1 dry weight (L-tryptophan in P. robustus). Four free phenolic acids were detected in methanolic extracts by the HPLC method. The total content ranged from 9.9 mg x 100 g1 DW (P. igniarius) to 32.5 mg x 100 g1 DW (P. robustus).

scholarly journals Benzo[f]indole-4,9-dione Derivatives Effectively Inhibit the Growth of Triple-Negative Breast Cancer

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4414
Author(s):  
Fabiana Sélos Guerra ◽  
Flaviana Rodrigues Fintelman Dias ◽  
Anna Claudia Cunha ◽  
Patricia Dias Fernandes
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Cell Line ◽  
Caspase 9 ◽  
Apoptosis Pathway ◽  
Indole Compounds ◽  
Intrinsic Apoptosis Pathway ◽  
Ros Accumulation

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor clinical outcome, and currently no effective targeted therapies are available. Indole compounds have been shown to have potential antitumor activity against various cancer cells. In the present study, we found that new four benzo[f]indole-4,9-dione derivatives reduce TNBC cell viability by reactive oxygen species (ROS) accumulation stress in vitro. Further analyses showed that LACBio1, LACBio2, LACBio3 and LACBio4 exert cytotoxic effects on MDA-MB 231 cancer cell line by inducing the intrinsic apoptosis pathway, activating caspase 9 and Bax/Bcl-2 pathway in vitro. These results provide evidence that these new four benzo[f]indole-4,9-dione derivatives could be potential therapeutic agents against TNBC by promoting ROS stress-mediated apoptosis through intrinsic-pathway caspase activation.

Indole Compounds: Isolation from Pineal Tissue

Science ◽  
1965 ◽  
Vol 148 (3666) ◽  
pp. 102-103 ◽  
Author(s):  
W. M. McIsaac ◽  
G. Farrell ◽  
R. G. Taborsky ◽  
A. N. Taylor
Keyword(s):  
Indole Compounds

scholarly journals Effective derivatization of indole compounds in negative ion chemical ionization mass spectrometry.

1983 ◽  
Vol 31 (4) ◽  
pp. 289-295 ◽  
Author(s):  
Tokishi Hayashi ◽  
Hiroshi Naruse ◽  
Satoru Kamada ◽  
Yoshio Iida ◽  
Shigeki Daishima ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Chemical Ionization ◽  
Negative Ion ◽  
Ionization Mass Spectrometry ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Indole Compounds ◽  
Negative Ion Chemical Ionization

ChemInform Abstract: Enantioselective Phase-Transfer-Catalyzed Intramolecular Aza-Michael Reaction: Effective Route to Pyrazino-Indole Compounds.

ChemInform ◽  
2008 ◽  
Vol 39 (34) ◽  
Author(s):  
Marco Bandini ◽  
Astrid Eichholzer ◽  
Michele Tragni ◽  
Achille Umani-Ronchi
Keyword(s):  
Michael Reaction ◽  
Phase Transfer ◽  
Indole Compounds

Inhibition of tyrosinase by indole compounds and reaction products protection by albumin

1979 ◽  
Vol 585 (3) ◽  
pp. 398-404 ◽  
Author(s):  
Miranda Michele ◽  
Giacinto Urbani ◽  
Laura Di Vito ◽  
Dario Botti
Keyword(s):  
Reaction Products ◽  
Indole Compounds

ChemInform Abstract: Unsaturated Sulfinamides. Part 16. Substituted N-Aryl-alk-1- enesulfinamides: Preparation, Properties and Conversion into the Corresponding Indole Compounds.

ChemInform ◽  
2010 ◽  
Vol 27 (42) ◽  
pp. no-no
Author(s):  
J.-B. BAUDIN ◽  
M.-G. COMMENIL ◽  
S. A. JULIA ◽  
R. LORNE ◽  
L. MAUCLAIRE
Keyword(s):  
Indole Compounds
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