scholarly journals Flavonoid Intake and Plasma Sex Steroid Hormones, Prolactin, and Sex Hormone-Binding Globulin in Premenopausal Women

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2669
Author(s):  
You Wu ◽  
Susan E. Hankinson ◽  
Stephanie A. Smith-Warner ◽  
Molin Wang ◽  
A. Heather Eliassen
Keyword(s):  
Linear Models ◽  
Geometric Mean ◽  
Plasma Concentrations ◽  
Premenopausal Women ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Health Study ◽  
Hormone Binding ◽  
Chemical Structures ◽  
Flavonoid Intake

Background: Flavonoids potentially exert anti-cancer effects, as suggested by their chemical structures and supported by animal studies. In observational studies, however, the association between flavonoids and breast cancer, and potential underlying mechanisms, remain unclear. Objective: To examine the relationship between flavonoid intake and sex hormone levels using timed blood samples in follicular and luteal phases in the Nurses’ Health Study II among premenopausal women. Methods: Plasma concentrations of estrogens, androgens, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), prolactin, and sex hormone-binding globulin (SHBG) were measured in samples collected between 1996 and 1999. Average flavonoid were calculated from semiquantitative food frequency questionnaires collected in 1995 and 1999. We used generalized linear models to calculate geometric mean hormone concentrations across categories of the intake of flavonoids and the subclasses. Results: Total flavonoid intake generally was not associated with the hormones of interest. The only significant association was with DHEAS (p-trend = 0.02), which was 11.1% (95% confidence interval (CI): −18.6%, −3.0%) lower comparing the highest vs. lowest quartile of flavonoid intake. In subclass analyses, the highest (vs. lowest) quartile of flavan-3-ol intake was associated with significantly lower DHEAS concentrations (−11.3% with 95% CI: −18.3%, −3.7%, p-trend = 0.01), and anthocyanin intake was associated with a significant inverse trend for DHEA (−18.0% with 95% CI: −27.9%, −6.7%, p-trend = 0.003). Conclusion: Flavonoid intake in this population had limited impact on most plasma sex hormones in premenopausal women. Anthocyanins and flavan-3-ols were associated with lower levels of DHEA and DHEAS.

scholarly journals Alcohol Consumption in Relation to Plasma Sex Hormones, Prolactin, and Sex Hormone–Binding Globulin in Premenopausal Women

2014 ◽  
Vol 23 (12) ◽  
pp. 2943-2953 ◽  
Author(s):  
Kelly A. Hirko ◽  
Donna Spiegelman ◽  
Walter C. Willett ◽  
Susan E. Hankinson ◽  
A. Heather Eliassen
Keyword(s):  
Alcohol Consumption ◽  
Sex Hormones ◽  
Premenopausal Women ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Patterns of plasma sex hormone-binding globulin, thyroxine and thyroxine-binding globulin in relation to reproductive state and hibernation in female little brown bats

1991 ◽  
Vol 128 (1) ◽  
pp. 63-70 ◽  
Author(s):  
G. G. Kwiecinski ◽  
D. A. Damassa ◽  
A. W. Gustafson
Keyword(s):  
Seasonal Pattern ◽  
Plasma Concentrations ◽  
Late Pregnancy ◽  
Electrophoretic Analysis ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Thyroxine Binding Globulin ◽  
Molecular Variant ◽  
Little Brown Bats

ABSTRACT A sex hormone-binding globulin (SHBG), which bound both oestradiol and dihydrotestosterone, was studied in the plasma of adult female little brown bats throughout the annual reproductive cycle. This protein was present at low baseline levels from September to May inclusive, months which correspond to the periods of hibernation, ovulation and early pregnancy. During the second half of pregnancy in June, SHBG levels increased 15- to 30-fold and remained increased throughout lactation and anoestrus/pro-oestrus (July–August). Although SHBG was increased during late pregnancy, the fact that levels were also high during and after lactation indicates that this protein is not specific to pregnancy. Plasma concentrations of thyroxine (T4) and the percentage binding of T4 to thyroxine-binding globulin (TBG) also showed marked seasonal variations, with T4 levels exhibiting a biphasic seasonal pattern. A major peak in plasma concentrations of T4 occurred around the time of spring arousal from hibernation and subsequent ovulation, while a second peak of lesser magnitude was measured in August, corresponding to the time of pro-oestrus and the onset of mating. The percentage binding of T4 by TBG was increased during the summer months in parallel with the increase in SHBG concentrations. Electrophoretic analysis of plasma T4 binding revealed a single peak of TBG activity throughout most of the year; however, during the early lactational period TBG was resolved as a double peak, suggesting the presence of a molecular variant during this reproductive stage. Journal of Endocrinology (1991) 128, 63–70

scholarly journals Salivary and Plasma Free Testosterone and Androstenedione Levels in Women Using Oral Contraceptives Containing Desogestrel or Levonorgestrel

1988 ◽  
Vol 25 (4) ◽  
pp. 354-359 ◽  
Author(s):  
L M J W Swinkels ◽  
P M M Meulenberg ◽  
H A Ross ◽  
Th J Benraad
Keyword(s):  
Oral Contraceptives ◽  
Plasma Concentrations ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Direct Assay

The effect of oral contraceptives (OC) containing a combination of ethinyloestradiol (EE2) and either desogestrel (Dg/EE2) or levonorgestrel (Lg/EE2) on plasma concentrations of sex hormone binding globulin (SHBG), total testosterone (T), free T, total androstenedione (A), free A and on salivary T and A concentrations have been studied. SHBG concentrations were higher in the Dg/EE2 group than in the Lg/EE2 group. Total T, measured by RIA with prior extraction and chromatography, is also higher in the Dg/EE2 group. Per cent free T was lower in the Dg/EE2 group. Plasma free T and free A concentrations were the same in both groups. However, free T and free A were significantly lower in the OC-groups than in controls. In contrast, by direct assay, no difference in total T was observed between the OC-groups. Since the per cent free T was lower in the Dg/EE2 group, it would be concluded that free T in the Dg/EE2 group is lower than in the Lg/EE2 group. Salivary free T and free A concentrations did not differ between control and OC-groups. There was good correlation between salivary and free hormone concentrations within each group. We conclude that the concentrations of androgens in saliva do not necessarily directly reflect their free concentrations in plasma.

scholarly journals Dietary Patterns and Plasma Sex Hormones, Prolactin, and Sex Hormone–Binding Globulin in Premenopausal Women

2016 ◽  
Vol 25 (5) ◽  
pp. 791-798 ◽  
Author(s):  
Kelly A. Hirko ◽  
Donna Spiegelman ◽  
Junaidah B. Barnett ◽  
Eunyoung Cho ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Dietary Patterns ◽  
Premenopausal Women ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

scholarly journals Dietary β-Tocopherol and Linoleic Acid, Serum Insulin, and Waist Circumference Predict Circulating Sex Hormone-Binding Globulin in Premenopausal Women

2009 ◽  
Vol 139 (6) ◽  
pp. 1135-1142 ◽  
Author(s):  
Fatima Nayeem ◽  
Manubai Nagamani ◽  
Karl E. Anderson ◽  
Yafei Huang ◽  
James J. Grady ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Waist Circumference ◽  
Serum Insulin ◽  
Premenopausal Women ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding
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