scholarly journals Relationship between insulin sensitivity and insulin secretion rate: not necessarily hyperbolic

2016 ◽  
Vol 33 (7) ◽  
pp. 961-967 ◽  
Author(s):  
S. H. Kim ◽  
A. Silvers ◽  
J. Viren ◽  
G. M. Reaven
Keyword(s):  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Secretion Rate ◽  
Insulin Secretion Rate

Relationship of Insulin Secretion Rate to Blood Glucose Concentration in Newborn and Adult Dogs

Neonatology ◽  
1969 ◽  
Vol 14 (3-4) ◽  
pp. 194-202 ◽  
Author(s):  
P.A.J. Adam ◽  
D. Kornhauser ◽  
D. Link ◽  
R. Schwartz
Keyword(s):  
Insulin Secretion ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Secretion Rate ◽  
Relationship Of ◽  
Insulin Secretion Rate

Twenty-four-hour rhythms of plasma glucose and insulin secretion rate in regular night workers

2000 ◽  
Vol 278 (3) ◽  
pp. E413-E420 ◽  
Author(s):  
C. Simon ◽  
L. Weibel ◽  
G. Brandenberger
Keyword(s):  
Insulin Secretion ◽  
Mean Amplitude ◽  
Sampling Procedure ◽  
Time Of Day ◽  
Secretion Rate ◽  
Nocturnal Sleep ◽  
Sleep Condition ◽  
The Mean ◽  
Nighttime Sleep ◽  
Insulin Secretion Rate

To determine whether the ultradian and circadian rhythms of glucose and insulin secretion rate (ISR) are adapted to their permanent nocturnal schedule, eight night workers were studied during their usual 24-h cycle with continuous enteral nutrition and a 10-min blood sampling procedure and were compared with 8 day-active subjects studied once with nocturnal sleep and once with an acute 8-h-shifted sleep. The mean 24-h glucose and ISR levels were similar in the three experiments. The duration and the number of the ultradian oscillations were influenced neither by the time of day nor by the sleep condition or its shift, but their mean amplitude increased during sleep whenever it occurred. In day-active subjects, glucose and ISR levels were high during nighttime sleep and then decreased to a minimum in the afternoon. After the acute sleep shift, the glucose and ISR rhythms were split in a biphasic pattern with a slight increase during the night of deprivation and another during daytime sleep. In night workers, the glucose and ISR peak levels exhibited an 8-h shift in accordance with the sleep shift, but the onset of the glucose rise underwent a shift of only 6 h and the sleep-related amplification of the glucose and ISR oscillations did not occur simultaneously. These results demonstrate that despite a predominant influence of sleep, the 24-h glucose and ISR rhythms are only partially adapted in permanent night workers.

Pancreatic beta-cell function and glucose metabolism in human segmental pancreas and kidney transplantation

1993 ◽  
Vol 264 (3) ◽  
pp. E441-E449 ◽  
Author(s):  
E. Christiansen ◽  
H. B. Andersen ◽  
K. Rasmussen ◽  
N. J. Christensen ◽  
K. Olgaard ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Glucose Metabolism ◽  
Beta Cell ◽  
Kidney Transplant ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Secretion Rate ◽  
C Peptide ◽  
Insulin Secretion Rate

beta-Cell function and glucose metabolism were studied in eight insulin-dependent diabetic recipients of combined segmental pancreas and kidney transplant with peripheral insulin delivery (Px), in eight nondiabetic kidney-transplant individuals (Kx), and in eight normal subjects (Ns) after three consecutive mixed meals. All subjects had normal fasting plasma glucose, but increased basal levels of C-peptide were demonstrated in the transplant groups (P < 0.05 relative to Ns). Postprandial hyperglycemia was increased 14% in Kx and 32% in Px (P < 0.05), whereas compared with Ns postprandial C-peptide levels were increased three- and twofold, respectively, in Kx and Px (P < 0.05). Compared with Ns basal insulin secretion rate (combined model) was increased 2-fold in Kx and 1.4-fold in Px (P < 0.05). Maximal insulin secretion rate was reduced 25% in Px compared with Kx (P < 0.05) but not different from that of Ns (P NS). Also, maximal insulin secretion rate occurred later in Px than in controls (Tmax: Px 50 min, Kx 30 min, and Ns 32 min; P < 0.05). The total integrated insulin secretion was increased 1.4-fold in Px compared with Ns (P < 0.05) but decreased 1.4-fold compared with Kx (P < 0.05). Fasting and postprandial proinsulin-to-C-peptide molar ratios were inappropriately increased in Px compared with Kx and Ns. Basal hepatic glucose production was increased 43% in Px and 33% in Kx compared with Ns (P < 0.05). Postprandial total systemic glucose appearance was similar in all three groups, whereas peripheral glucose disposal was 15% reduced in Px (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Basal and 24-h C-peptide and insulin secretion rate in normal man

Diabetologia ◽  
1987 ◽  
Vol 30 (1) ◽  
pp. 16-21 ◽  
Author(s):  
Y. T. Kruszynska ◽  
P. D. Home ◽  
I. Hanning ◽  
K. G. M. M. Alberti
Keyword(s):  
Insulin Secretion ◽  
Secretion Rate ◽  
C Peptide ◽  
Normal Man ◽  
Insulin Secretion Rate

scholarly journals The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects

2004 ◽  
Vol 92 (6) ◽  
pp. 895-903 ◽  
Author(s):  
Melania Manco ◽  
Alessandro Bertuzzi ◽  
Serenella Salinari ◽  
Antonino Scarfone ◽  
Menotti Calvani ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Human Subjects ◽  
Saturated Fat ◽  
Normal Weight ◽  
Insulin Clearance ◽  
Water Load ◽  
Obese Subjects ◽  
Insulin Secretion Rate ◽  
Saturated Fat Intake

To assess the effects of acute dietary saturated fat intake on glucose-induced insulin secretion rate (ISR), measured by the C-peptide deconvolution method, and on insulin clearance and sensitivity, five obese and five normal-weight women (controls) were studied after either a 100g oral butter load or a 100ml water load. At 120min after the oral load a hyperglycaemic clamp was performed over 180min. A dramatic increase of ISR occurred after butter compared with the water challenge in the controls (1305·6 (SE 124·1) v. 616·1 (SE 52·5) pmol/min; P<0·01) and to a lesser degree in the obese subjects (1975·0 (SE 44·1) v. 1417·5 (SE 56·0) pmol/min; P<0·05). Insulin sensitivity was impaired after butter (0·60×10−2 (SE 0·11×10−2) v. 2·26×10−2 (SE 0·32×10−2) ml/min per kgFFM per (pmol/l); P<0·01) in the controls but not in the obese group. Insulin clearance during the clamp was reduced after butter compared with after the water load only in the controls (0·89 (SE 0·22) v. 1·70 (SE 0·15) litres/min; P<0·01). The data are consistent with the hypothesis that acute excess lipid availability may lead to a compensatory elevation in glucose-induced insulin secretion as a result of the decline in insulin sensitivity and a reduced insulin clearance.

scholarly journals Slow Oscillations of Plasma Glucose and Insulin Secretion Rate Are Amplified During Sleep in Humans Under Continuous Enteral Nutrition

SLEEP ◽  
1994 ◽  
Vol 17 (4) ◽  
pp. 333-338 ◽  
Author(s):  
C. Simon ◽  
G. Brandenberger ◽  
J. Saini ◽  
J. Ehrhart ◽  
M. Follenius
Keyword(s):  
Insulin Secretion ◽  
Enteral Nutrition ◽  
Plasma Glucose ◽  
Secretion Rate ◽  
Slow Oscillations ◽  
Insulin Secretion Rate
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