The only method to restore missing teeth, refunded by the Polish National Health Found, is acrylic partial denture, which is often the cause of prosthetic stomatopathy, that affects both the dentition and the mucous membrane. The soluble urokinase plasminogen activator receptor (suPAR) was used to assess this type of chronic inflammatory response, which is also a factor that accelerates the development of atherosclerosis and its clinical outcomes. Comparative analysis of suPAR concentrations (ELISA suPARNostic, Virogates) was performed in group of people using acrylic dentures for up to 5 years in relation to the group of people using them longer and against the group of the people who do not use prostheses, also in relation to other laboratory parameters related to inflammatory response. The results of the study conducted in the total group of 117 people, of which 77 were using acrylic dentures, showed that in patients who used them longer (> 5years), greater intensity of changes in the oral cavity and higher suPAR levels (Me=3.95 ng/mL) were observed, in comparison to patients who do not use prostheses (Me=3.12 ng/mL), as well as patients who used them less than 5 years (Me=3.43 ng/mL); p = 0.00002. The concentration of suPAR significantly positively correlated with the concentration of LDL cholesterol, triglycerides, C-reactive protein and the number of white blood cells and neutrophils in the studied population (R>0.2; p<0.05), and was significantly higher in smokers (3.84 vs 3.24 ng/mL, p=0.04). No other laboratory marker of inflammatory response showed similar discriminatory properties. The demonstrated increases in suPAR concentrations were associated with existing local inflammation in patients using acrylic dentures. More intense inflammatory process occurred in patients using prostheses over 5 years and who have pathological changes in the oral cavity.
Soluble urokinase plasminogen activator receptor for the prediction of ventilator-associated pneumonia
